利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

101 条记录 (耗时 0.047 秒)

    Therapeutic agent for malignant tumors expressing MHC class II
    4.
    发明授权
    Therapeutic agent for malignant tumors expressing MHC class II 有权
    表达MHC II类恶性肿瘤的治疗剂

    公开(公告)号：US09303083B2

    公开(公告)日：2016-04-05

    申请号：US13877844

    申请日：2011-10-04

    申请人： Shuji Matsuoka ,  Yasuyuki Ishii

    发明人： Shuji Matsuoka ,  Yasuyuki Ishii

    IPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/30

    CPC分类号： C07K16/18 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/34 ,  G01N2333/70539

    摘要： Provided is a novel therapeutic agent specific for a malignant tumor expressing MHC class II. The present invention provides an antibody recognizing a protein constituting MHC class II expressed on a malignant tumor, the antibody comprising at least one selected from heavy chain CDR1 (amino acid sequence represented by positions 49 to 54 of SEQ ID NO: 54), heavy chain CDR2 (amino acid sequence represented by positions 69 to 84 of SEQ ID NO: 54), heavy chain CDR3 (amino acid sequence represented by positions 117 to 128 of SEQ ID NO: 54), light chain CDR1 (amino acid sequence represented by positions 46 to 55 of SEQ ID NO: 56), light chain CDR2 (amino acid sequence represented by positions 71 to 77 of SEQ ID NO: 56), and light chain CDR3 (amino acid sequence represented by positions 100 to 108 of SEQ ID NO: 56).

    摘要翻译： 提供一种特异于表达II类MHC的恶性肿瘤的新型治疗剂。 本发明提供一种抗体，其识别构成在恶性肿瘤上表达的II类MHC的蛋白质，所述抗体包含选自重链CDR1（SEQ ID NO：54的49至54位的氨基酸序列）中的至少一种，重链 CDR2（SEQ ID NO：54的第69〜84位的氨基酸序列），重链CDR3（SEQ ID NO：54的117〜128位的氨基酸序列），轻链CDR1（由位置 SEQ ID NO：56的46〜55），轻链CDR2（由SEQ ID NO：56的71〜77位表示的氨基酸序列）和轻链CDR3（SEQ ID NO： ：56）。

    Image forming apparatus
    5.
    发明授权
    Image forming apparatus 有权
    图像形成装置

    公开(公告)号：US08948638B2

    公开(公告)日：2015-02-03

    申请号：US13215700

    申请日：2011-08-23

    申请人： Yuji Ishikura ,  Yasuyuki Ishii ,  Hideki Kosugi ,  Tetsuro Hirota ,  Masaaki Yamada ,  Yoshiko Ogawa ,  Atsushi Kurokawa ,  Hideyasu Seki ,  Masanori Horike ,  Shin Kayahara

    发明人： Yuji Ishikura ,  Yasuyuki Ishii ,  Hideki Kosugi ,  Tetsuro Hirota ,  Masaaki Yamada ,  Yoshiko Ogawa ,  Atsushi Kurokawa ,  Hideyasu Seki ,  Masanori Horike ,  Shin Kayahara

    IPC分类号： G03G15/06 ,  G03G15/08 ,  G03G15/01 ,  G03G15/16

    CPC分类号： G03G15/0131 ,  G03G15/0189 ,  G03G15/1605

    摘要： An image forming apparatus includes a latent image carrier; a latent image writer to write a latent image on the latent image carrier; a developing unit including a toner carrier having first and second electrodes insulated via an insulator member and a voltage applying unit to apply voltages to the first and second electrodes having a potential difference to generate first electric fields to cause the toner to hop from the toner carrier to the latent image carrier to develop a toner image; and a transfer unit to transfer the developed toner image to a transferring member. When alternating voltages having a same phase and same amplitude are applied to the first and second electrodes to form second electric fields between the latent image carrier and the toner carrier, the toner is discharged from the toner carrier to the latent image carrier in a toner discharge mode.

    摘要翻译： 图像形成装置包括潜像载体; 潜像写入器，用于在潜像载体上写入潜像; 显影单元，包括具有通过绝缘体构件绝缘的第一和第二电极的调色剂载体和施加电压的电压施加到具有电位差的第一和第二电极，以产生第一电场，以使调色剂从调色剂载体 到潜像载体以形成调色剂图像; 以及将显影的调色剂图像转印到转印部件的转印单元。 当具有相同相位和相同振幅的交变电压施加到第一和第二电极以在潜像载体和调色剂载体之间形成第二电场时，调色剂在调色剂排出物中从调色剂载体排出到潜像载体 模式。

    Method for quantification of antigen-specific canine IgE
    6.
    发明授权
    Method for quantification of antigen-specific canine IgE 有权
    抗原特异性犬IgE定量方法

    公开(公告)号：US08716031B2

    公开(公告)日：2014-05-06

    申请号：US12992476

    申请日：2009-05-12

    申请人： Kenichi Masuda ,  Yasuyuki Ishii ,  Nobutaka Yasuda

    发明人： Kenichi Masuda ,  Yasuyuki Ishii ,  Nobutaka Yasuda

    IPC分类号： C07K16/06 ,  C07K16/42 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/543 ,  G01N33/563 ,  G01N33/96 ,  G01N33/68 ,  C12N5/20 ,  C12N5/16

    CPC分类号： G01N33/6854 ,  C07K16/06 ,  C07K16/42 ,  C07K16/4291 ,  C07K2317/33 ,  C12N5/163 ,  G01N33/536 ,  G01N33/537 ,  G01N33/543 ,  G01N33/96 ,  G01N2333/435 ,  G01N2469/20 ,  G01N2496/05 ,  G01N2800/24 ,  Y10S435/975 ,  Y10T436/10 ,  Y10T436/106664

    摘要： Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which comprises the following steps (A) to (D): (A) contacting a biological sample collected from a subject with an antigen to conjugate IgE contained in the sample with the antigen; (B) measuring the quantity of IgE in a standard sample collected from an experimental animal which is different from the subject and has been sensitized with the same antigen as that used in step (A) by using a substance capable of recognizing both IgE from the subject and IgE from the experimental animal, thereby producing a standard curve; (C) detecting a conjugate formed in step (A) by using the same substance capable of recognizing both IgE from the subject and IgE from the experimental animal as that used in step (B); and (D) determining the quantity of IgE in the biological sample collected from the subject by utilizing the quantity of the conjugate detected in step (C) and the standard curve produced in step (B). Also specifically disclosed is a method for quantifying an antigen-specific human IgE.

    摘要翻译： 公开了用于定量抗原特异性犬或人IgE的方便和有效的方法。 具体公开的是定量抗原特异性犬IgE的方法，其包括以下步骤（A）至（D）：（A）使从受试者收集的生物样品与抗原接触，将样品中含有的IgE与 抗原; （B）测量从与受试者不同的实验动物收集的标准样品中的IgE的量，并且已经用与步骤（A）中使用的相同的抗原致敏，通过使用能够识别来自 受试者和IgE，从而产生标准曲线; （C）通过使用能够从受试者中识别出两种IgE的相同物质和步骤（B）中使用的实验动物的IgE，检测步骤（A）中形成的缀合物; 和（D）通过利用在步骤（C）中检测到的共轭物的量和步骤（B）中产生的标准曲线来确定从受试者收集的生物样品中的IgE的量。 还具体公开了一种定量抗原特异性人IgE的方法。

    METHOD FOR QUANTIFICATION OF ANTIGEN-SPECIFIC CANINE OR HUMAN IGE
    8.
    发明申请
    METHOD FOR QUANTIFICATION OF ANTIGEN-SPECIFIC CANINE OR HUMAN IGE 有权
    抗原特异性犬或人脑的定量方法

    公开(公告)号：US20110111529A1

    公开(公告)日：2011-05-12

    申请号：US12992476

    申请日：2009-05-12

    申请人： Kenichi Masuda ,  Yasuyuki Ishii ,  Nobutaka Yasuda

    发明人： Kenichi Masuda ,  Yasuyuki Ishii ,  Nobutaka Yasuda

    IPC分类号： G01N33/566

    CPC分类号： G01N33/6854 ,  C07K16/06 ,  C07K16/42 ,  C07K16/4291 ,  C07K2317/33 ,  C12N5/163 ,  G01N33/536 ,  G01N33/537 ,  G01N33/543 ,  G01N33/96 ,  G01N2333/435 ,  G01N2469/20 ,  G01N2496/05 ,  G01N2800/24 ,  Y10S435/975 ,  Y10T436/10 ,  Y10T436/106664

    摘要： Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which comprises the following steps (A) to (D): (A) contacting a biological sample collected from a subject with an antigen to conjugate IgE contained in the sample with the antigen; (B) measuring the quantity of IgE in a standard sample collected from an experimental animal which is different from the subject and has been sensitized with the same antigen as that used in step (A) by using a substance capable of recognizing both IgE from the subject and IgE from the experimental animal, thereby producing a standard curve; (C) detecting a conjugate formed in step (A) by using the same substance capable of recognizing both IgE from the subject and IgE from the experimental animal as that used in step (B); and (D) determining the quantity of IgE in the biological sample collected from the subject by utilizing the quantity of the conjugate detected in step (C) and the standard curve produced in step (B). Also specifically disclosed is a method for quantifying an antigen-specific human IgE.

    摘要翻译： 公开了用于定量抗原特异性犬或人IgE的方便和有效的方法。 具体公开的是定量抗原特异性犬IgE的方法，其包括以下步骤（A）至（D）：（A）使从受试者收集的生物样品与抗原接触，将样品中含有的IgE与 抗原; （B）测量从与受试者不同的实验动物收集的标准样品中的IgE的量，并且已经用与步骤（A）中使用的相同的抗原致敏，通过使用能够识别来自 受试者和IgE，从而产生标准曲线; （C）通过使用能够从受试者中识别出两种IgE的相同物质和步骤（B）中使用的实验动物的IgE，检测步骤（A）中形成的缀合物; 和（D）通过利用在步骤（C）中检测到的共轭物的量和步骤（B）中产生的标准曲线来确定从受试者收集的生物样品中的IgE的量。 还具体公开了一种定量抗原特异性人IgE的方法。

    Development device and image forming apparatus that uses this device
    9.
    发明授权
    Development device and image forming apparatus that uses this device 有权
    使用该装置的显影装置和图像形成装置

    公开(公告)号：US07920812B2

    公开(公告)日：2011-04-05

    申请号：US12261302

    申请日：2008-10-30

    申请人： Hideki Kosugi ,  Yasuyuki Ishii ,  Tomoko Takahashi ,  Masaaki Yamada ,  Ichiro Kadota ,  Yoshinori Nakagawa

    发明人： Hideki Kosugi ,  Yasuyuki Ishii ,  Tomoko Takahashi ,  Masaaki Yamada ,  Ichiro Kadota ,  Yoshinori Nakagawa

    IPC分类号： G03G15/08

    CPC分类号： G03G15/0818 ,  G03G2215/0653

    摘要： A development device provided with a first electrode layer and a second electrode layer, which are laminated so as to overlap one another in a normal direction with respect to the surface of the roller part of the toner bearing roller. A plurality of openings are provided in the second electrode layer, over the entire latent image bearable area of a photosensitive body in the orthogonal-to-movement direction. The toner on the surface of the roller part is caused to hop between a plurality of spots directly beneath the openings that respectively exist directly beneath the plurality of openings in the second electrode layer, and a plurality of spots between the openings that respectively exist between the plurality of openings in the second electrode layer, within the entire area of the first electrode layer which is uniformly formed in the roller circumferential direction.

    摘要翻译： 一种显影装置，其具有第一电极层和第二电极层，该第一电极层和第二电极层相对于调色剂承载辊的辊部的表面在法线方向上彼此重叠。 在第二电极层中，在正交移动方向上的感光体的整个潜像可承受区域上设置多个开口。 导致辊部分表面上的调色剂在直接位于开口下面的多个位于第二电极层的多个开口正下方的多个点之间跳跃，并且开口之间的多个点分别存在于第二电极层之间 在第一电极层的沿辊周向均匀地形成的整个区域内的第二电极层中的多个开口。