公开(公告)号：US06529699B2

公开(公告)日：2003-03-04

申请号：US09803971

申请日：2001-03-13

申请人： Yasuyuki Ishii ,  Tetsuya Kobayashi ,  Tsuyoshi Nakagawa ,  Shinji Uehara

发明人： Yasuyuki Ishii ,  Tetsuya Kobayashi ,  Tsuyoshi Nakagawa ,  Shinji Uehara

IPC分类号： G03G1500

CPC分类号： G03G9/0823 ,  G03G9/0827 ,  G03G13/00

摘要： An image forming apparatus and a process cartridge have a wide optimum range of the toner charging amount and produce an excellent gradient and have an image bearing body and a developer carrying body. The electrostatic capacity of the image bearing body per cm2 is not less than 150 pF and not greater than 600 pF.

摘要翻译： 图像形成装置和处理盒具有广泛的调色剂充电量的最佳范围并产生优异的梯度并具有图像承载体和显影剂承载体。 图像承载体每cm 2的静电容量不小于150 pF且不大于600 pF。

公开(公告)号：US06647230B2

公开(公告)日：2003-11-11

申请号：US09942657

申请日：2001-08-31

申请人： Tetsuya Kobayashi ,  Yasuyuki Ishii ,  Tsuyoshi Nakagawa ,  Shinji Uehara

发明人： Tetsuya Kobayashi ,  Yasuyuki Ishii ,  Tsuyoshi Nakagawa ,  Shinji Uehara

IPC分类号： G03G1500

CPC分类号： G03G9/0918 ,  G03G9/08 ,  G03G9/08755 ,  G03G9/0904 ,  G03G9/092 ,  G03G9/097 ,  G03G9/09783 ,  G03G13/08

摘要： An image-forming apparatus includes an image-bearing member for holding thereon an electrostatic latent image; a charging device for electrostatically charging a surface of the image-bearing member; an exposure unit for forming the electrostatic latent image on the image-bearing member by exposing to light the image-bearing member having been charged by the charging device; and a developing unit which has at least a toner-carrying member for carrying and transporting a negatively-chargeable toner thereon and developing the electrostatic latent image by a contact developing system to form a toner image. In the triboelectric series relationship between the toner and a surface layer of the image-bearing member, the surface layer of the image-bearing member has a charge polarity which is a different polarity with respect to the charge polarity of the toner in the developing unit. The image-bearing member includes the electrostatic latent image including a surface potential, as a nonimage area potential (Vd) within a range of −500 to −800 V, and as an image area potential (Vl), at which the maximum toner image density is to be obtained, within a range of −50 to −200 V. A process cartridge includes the above-described image-bearing member.

摘要翻译： 图像形成装置包括用于保持静电潜像的图像承载部件; 用于对图像承载部件的表面进行静电充电的充电装置; 曝光单元，用于通过对由充电装置充电的图像承载部件进行曝光而在图像承载部件上形成静电潜像; 以及显影单元，该显影单元至少具有用于在其上承载和传送可带负电荷的调色剂的调色剂承载构件，并通过接触显影系统显影静电潜像以形成调色剂图像。 在调色剂和图像承载部件的表面层之间的摩擦系列关系中，图像承载部件的表面层具有相对于显影单元中的调色剂的电荷极性具有不同极性的电荷极性 。 图像承载部件包括包括表面电位的静电潜像，作为在-500至-800V的范围内的非图像区域电位（Vd），以及作为图像区域电位（V1），其中最大调色剂图像 要在-50至-200V的范围内获得密度。处理盒包括上述图像承载部件。

公开(公告)号：US06574444B2

公开(公告)日：2003-06-03

申请号：US09772977

申请日：2001-01-31

申请人： Shinji Uehara ,  Tetsuya Kobayashi ,  Yasuyuki Ishii ,  Tsuyoshi Nakagawa

发明人： Shinji Uehara ,  Tetsuya Kobayashi ,  Yasuyuki Ishii ,  Tsuyoshi Nakagawa

IPC分类号： G03G1508

CPC分类号： G03G15/0817

摘要： A developing apparatus includes a developing container for containing a developer therein. A developing carrying member, provided in an opening portion of the developing container, for developing an electrostatic image on an image bearing member, the developer carrying member having a rubber layer and a surface layer on the rubber layer. A seal member is provided in the opening portion for preventing leakage of the developer from an end portion of the opening portion. The seal member provided in the opening portion for preventing leakage of the developer from an end portion of the opening portion, wherein the seal member is in contact with the surface layer except for an end edge thereof.

摘要翻译： 显影装置包括用于在其中容纳显影剂的显影容器。 一种显影承载构件，设置在显影容器的开口部分中，用于在图像承载构件上显影静电图像，显影剂承载构件在橡胶层上具有橡胶层和表面层。 密封构件设置在开口部分中，用于防止显影剂从开口部分的端部泄漏。 所述密封构件设置在所述开口部分中，用于防止所述显影剂从所述开口部分的端部泄漏，其中所述密封构件与除了其端部边缘之外的所述表面层接触。

公开(公告)号：US06314257B1

公开(公告)日：2001-11-06

申请号：US09515669

申请日：2000-02-29

申请人： Yasuyuki Ishii ,  Shinji Uehara ,  Tomomi Kakeshita

发明人： Yasuyuki Ishii ,  Shinji Uehara ,  Tomomi Kakeshita

IPC分类号： G03G1524

CPC分类号： G03G15/081

摘要： A simultaneous developing/cleaning device includes a developer carrying member for carrying a layer of developer, the developer carrying member forming a developing zone where the layer of the developer is contacted to the developer carrying member and to an image bearing member carrying a latent image; and a charge application member for applying electric charge to the developer carried on the developer carrying member by electric discharge, the charge application member being provided upstream of the developing zone with respect to a moving direction of the developer carrying member.

摘要翻译： 同时显影/清洁装置包括用于承载显影剂层的显影剂承载构件，显影剂承载构件形成显影区，显影剂层与显影剂承载构件接触，并且承载潜象的图像承载构件; 以及电荷施加构件，用于通过放电对携带在显影剂承载构件上的显影剂施加电荷，电荷施加构件相对于显影剂承载构件的移动方向设置在显影区的上游。

公开(公告)号：US06522842B1

公开(公告)日：2003-02-18

申请号：US09663395

申请日：2000-09-15

申请人： Shinji Uehara ,  Yasuyuki Ishii ,  Tomomi Kakeshita

发明人： Shinji Uehara ,  Yasuyuki Ishii ,  Tomomi Kakeshita

IPC分类号： G03G1506

CPC分类号： G03G15/0806 ,  G03G2215/0634

摘要： In a developing apparatus having the configuration of charging toner on the developing roller with the toner charging roller, toner charging roller contacts to the developing roller. Since toner adheres onto the toner charging roller by applying the voltage higher than a starting voltage in the developing apparatus, electrifying property of the toner charging roller drops. This causes low image quality since stable charges cannot be given to the toner on the developing roller. Therefore, they are provided, a developing apparatus and an image forming apparatus that can always offer good image quality by preventing adhesion of a developing material to a developer-charging member and always giving stable charges to a developer bearing body and developer.

摘要翻译： 在具有利用调色剂充电辊在显影辊上充电调色剂的构造的显影装置中，调色剂充电辊与显影辊接触。 由于调色剂通过在显影装置中施加高于启动电压的电压而附着在调色剂充电辊上，所以调色剂充电辊的充电性能下降。 这导致低图像质量，因为不能给显影辊上的调色剂带来稳定的电荷。 因此，提供了一种显影装置和图像形成装置，其可以通过防止显影材料对显影剂充电部件的粘附并且总是对显影剂承载体和显影剂赋予稳定的电荷来始终提供良好的图像质量。

公开(公告)号：US06542710B2

公开(公告)日：2003-04-01

申请号：US09793082

申请日：2001-02-27

申请人： Tomomi Kakeshita ,  Yasuyuki Ishii ,  Shinji Uehara

发明人： Tomomi Kakeshita ,  Yasuyuki Ishii ,  Shinji Uehara

IPC分类号： G03G1508

CPC分类号： G03G15/0806 ,  G03G2215/0634

摘要： A developing apparatus in which a developer is prevented from attaching to a developer electrifying member. The developing apparatus has a developer carrying body, a regulating member, and a developer carrying member, wherein during a period when developing action is not conducted by the developer carrying body and residual developer is being cleaned, there is a first period during which a first electric field is formed in a direction in which the developer normally charged moves from the developer carrying body to the developer charging member and after the first period there is a second period during which a second electric field is formed in a direction in which the developer normally charged moves from the developer charging member to the developer carrying body.

摘要翻译： 防止显影剂附着在显影剂带电构件上的显影装置。 显影装置具有显影剂承载体，调节构件和显影剂承载构件，其中在显影剂承载体不进行显影动作和残留显影剂被清洁的时段期间，存在第一期间 在正常充电的显影剂从显影剂承载体移动到显影剂充电部件的方向上形成电场，并且在第一周期之后，存在第二时段，在该第二周期期间，在显影剂通常的方向上形成第二电场 带电从显影剂充电元件移动到显影剂承载体。

公开(公告)号：US06643484B2

公开(公告)日：2003-11-04

申请号：US10082203

申请日：2002-02-26

申请人： Katsuhiro Kojima ,  Tetsuya Kobayashi ,  Yasuyuki Ishii

发明人： Katsuhiro Kojima ,  Tetsuya Kobayashi ,  Yasuyuki Ishii

IPC分类号： G03G1501

CPC分类号： G03G15/0806 ,  G03G15/0126 ,  G03G2215/0119

摘要： An image forming apparatus includes an image bearing member and a developer carrying member, which carries a developer to develop an electrostatic image formed on the image bearing member with the developer. In a non-developmental time period, a peripheral velocity of the developer carrying member is slower than the peripheral velocity of the developer carrying member during a developmental time period. In addition, a peripheral velocity of the image bearing member during the non-developmental time period is slower than the peripheral velocity of the image bearing member during the development time period.

摘要翻译： 图像形成装置包括图像承载部件和显影剂承载部件，其承载显影剂以使显影剂形成在图像承载部件上形成的静电图像。 在非显影时间段中，显影剂承载构件的圆周速度比显影剂承载构件在显影时间段内的圆周速度慢。 此外，在显影时间段期间，图像承载部件的非显影时间段的圆周速度比图像承载部件的圆周速度慢。

公开(公告)号：US09303083B2

公开(公告)日：2016-04-05

申请号：US13877844

申请日：2011-10-04

申请人： Shuji Matsuoka ,  Yasuyuki Ishii

发明人： Shuji Matsuoka ,  Yasuyuki Ishii

IPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/30

CPC分类号： C07K16/18 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/34 ,  G01N2333/70539

摘要： Provided is a novel therapeutic agent specific for a malignant tumor expressing MHC class II. The present invention provides an antibody recognizing a protein constituting MHC class II expressed on a malignant tumor, the antibody comprising at least one selected from heavy chain CDR1 (amino acid sequence represented by positions 49 to 54 of SEQ ID NO: 54), heavy chain CDR2 (amino acid sequence represented by positions 69 to 84 of SEQ ID NO: 54), heavy chain CDR3 (amino acid sequence represented by positions 117 to 128 of SEQ ID NO: 54), light chain CDR1 (amino acid sequence represented by positions 46 to 55 of SEQ ID NO: 56), light chain CDR2 (amino acid sequence represented by positions 71 to 77 of SEQ ID NO: 56), and light chain CDR3 (amino acid sequence represented by positions 100 to 108 of SEQ ID NO: 56).

摘要翻译： 提供一种特异于表达II类MHC的恶性肿瘤的新型治疗剂。 本发明提供一种抗体，其识别构成在恶性肿瘤上表达的II类MHC的蛋白质，所述抗体包含选自重链CDR1（SEQ ID NO：54的49至54位的氨基酸序列）中的至少一种，重链 CDR2（SEQ ID NO：54的第69〜84位的氨基酸序列），重链CDR3（SEQ ID NO：54的117〜128位的氨基酸序列），轻链CDR1（由位置 SEQ ID NO：56的46〜55），轻链CDR2（由SEQ ID NO：56的71〜77位表示的氨基酸序列）和轻链CDR3（SEQ ID NO： ：56）。

公开(公告)号：US08948638B2

公开(公告)日：2015-02-03

申请号：US13215700

申请日：2011-08-23

申请人： Yuji Ishikura ,  Yasuyuki Ishii ,  Hideki Kosugi ,  Tetsuro Hirota ,  Masaaki Yamada ,  Yoshiko Ogawa ,  Atsushi Kurokawa ,  Hideyasu Seki ,  Masanori Horike ,  Shin Kayahara

发明人： Yuji Ishikura ,  Yasuyuki Ishii ,  Hideki Kosugi ,  Tetsuro Hirota ,  Masaaki Yamada ,  Yoshiko Ogawa ,  Atsushi Kurokawa ,  Hideyasu Seki ,  Masanori Horike ,  Shin Kayahara

IPC分类号： G03G15/06 ,  G03G15/08 ,  G03G15/01 ,  G03G15/16

CPC分类号： G03G15/0131 ,  G03G15/0189 ,  G03G15/1605

摘要： An image forming apparatus includes a latent image carrier; a latent image writer to write a latent image on the latent image carrier; a developing unit including a toner carrier having first and second electrodes insulated via an insulator member and a voltage applying unit to apply voltages to the first and second electrodes having a potential difference to generate first electric fields to cause the toner to hop from the toner carrier to the latent image carrier to develop a toner image; and a transfer unit to transfer the developed toner image to a transferring member. When alternating voltages having a same phase and same amplitude are applied to the first and second electrodes to form second electric fields between the latent image carrier and the toner carrier, the toner is discharged from the toner carrier to the latent image carrier in a toner discharge mode.

摘要翻译： 图像形成装置包括潜像载体; 潜像写入器，用于在潜像载体上写入潜像; 显影单元，包括具有通过绝缘体构件绝缘的第一和第二电极的调色剂载体和施加电压的电压施加到具有电位差的第一和第二电极，以产生第一电场，以使调色剂从调色剂载体 到潜像载体以形成调色剂图像; 以及将显影的调色剂图像转印到转印部件的转印单元。 当具有相同相位和相同振幅的交变电压施加到第一和第二电极以在潜像载体和调色剂载体之间形成第二电场时，调色剂在调色剂排出物中从调色剂载体排出到潜像载体 模式。

公开(公告)号：US08716031B2

公开(公告)日：2014-05-06

申请号：US12992476

申请日：2009-05-12

申请人： Kenichi Masuda ,  Yasuyuki Ishii ,  Nobutaka Yasuda

发明人： Kenichi Masuda ,  Yasuyuki Ishii ,  Nobutaka Yasuda

IPC分类号： C07K16/06 ,  C07K16/42 ,  G01N33/53 ,  G01N33/536 ,  G01N33/537 ,  G01N33/543 ,  G01N33/563 ,  G01N33/96 ,  G01N33/68 ,  C12N5/20 ,  C12N5/16

CPC分类号： G01N33/6854 ,  C07K16/06 ,  C07K16/42 ,  C07K16/4291 ,  C07K2317/33 ,  C12N5/163 ,  G01N33/536 ,  G01N33/537 ,  G01N33/543 ,  G01N33/96 ,  G01N2333/435 ,  G01N2469/20 ,  G01N2496/05 ,  G01N2800/24 ,  Y10S435/975 ,  Y10T436/10 ,  Y10T436/106664

摘要： Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which comprises the following steps (A) to (D): (A) contacting a biological sample collected from a subject with an antigen to conjugate IgE contained in the sample with the antigen; (B) measuring the quantity of IgE in a standard sample collected from an experimental animal which is different from the subject and has been sensitized with the same antigen as that used in step (A) by using a substance capable of recognizing both IgE from the subject and IgE from the experimental animal, thereby producing a standard curve; (C) detecting a conjugate formed in step (A) by using the same substance capable of recognizing both IgE from the subject and IgE from the experimental animal as that used in step (B); and (D) determining the quantity of IgE in the biological sample collected from the subject by utilizing the quantity of the conjugate detected in step (C) and the standard curve produced in step (B). Also specifically disclosed is a method for quantifying an antigen-specific human IgE.

摘要翻译： 公开了用于定量抗原特异性犬或人IgE的方便和有效的方法。 具体公开的是定量抗原特异性犬IgE的方法，其包括以下步骤（A）至（D）：（A）使从受试者收集的生物样品与抗原接触，将样品中含有的IgE与 抗原; （B）测量从与受试者不同的实验动物收集的标准样品中的IgE的量，并且已经用与步骤（A）中使用的相同的抗原致敏，通过使用能够识别来自 受试者和IgE，从而产生标准曲线; （C）通过使用能够从受试者中识别出两种IgE的相同物质和步骤（B）中使用的实验动物的IgE，检测步骤（A）中形成的缀合物; 和（D）通过利用在步骤（C）中检测到的共轭物的量和步骤（B）中产生的标准曲线来确定从受试者收集的生物样品中的IgE的量。 还具体公开了一种定量抗原特异性人IgE的方法。