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公开(公告)号：US20060020019A1
公开(公告)日：2006-01-26
申请号：US11188581
申请日：2005-07-25
申请人： Yazhong Huang , Shuanghua Hu , Andrew Degnan
发明人： Yazhong Huang , Shuanghua Hu , Andrew Degnan
IPC分类号： A61K31/381 , A61K31/277 , A61K31/138 , C07D333/22
CPC分类号： C07D333/20 , C07B2200/07 , C07C217/48 , C07C217/72 , C07C217/76 , C07C323/29
摘要： The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.
摘要翻译： 本发明包括式I化合物，包括其药学上可接受的盐和溶剂合物，它们的药物组合物及其在治疗与速激肽或血清素或过量或不均衡相关的疾病中的用途。
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2.发明授权Glycine chroman-6-sulfonamides for use as inhibitors of diacylglycerol lipase 有权用作二酰基甘油脂肪酶抑制剂的甘氨酸色满-6-磺酰胺公开(公告)号：US08404741B2
公开(公告)日：2013-03-26
申请号：US13025384
申请日：2011-02-11
申请人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
发明人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
IPC分类号： A01N43/16 , A01N37/12 , A01N37/44 , A61K31/35 , A61K31/195 , C07D317/70 , C07C51/16 , C07C229/00
CPC分类号： C07D311/70 , C07D239/26 , C07D277/28 , C07D407/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
摘要翻译： 本公开一般涉及可抑制DAGLα和/或bgr的化合物; 活性，包含这些化合物的组合物和抑制DAGLα和/或bgr的方法; 活动。
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公开(公告)号：US07179926B2
公开(公告)日：2007-02-20
申请号：US11188581
申请日：2005-07-25
申请人： Yazhong Huang , Shuanghua Hu , Andrew P. Degnan
发明人： Yazhong Huang , Shuanghua Hu , Andrew P. Degnan
IPC分类号： C07D333/16 , C07D333/46 , C07C211/00 , C07C217/44 , C07C321/06 , A61K31/135 , A61K31/38
CPC分类号： C07D333/20 , C07B2200/07 , C07C217/48 , C07C217/72 , C07C217/76 , C07C323/29
摘要： The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.
摘要翻译： 本发明包括式I化合物，包括其药学上可接受的盐和溶剂合物，它们的药物组合物及其在治疗与速激肽或血清素或过量或不均衡相关的疾病中的用途。
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公开(公告)号：US06875771B2
公开(公告)日：2005-04-05
申请号：US10620240
申请日：2003-07-15
IPC分类号： A61K31/519 , C07D471/04 , C07D471/14 , C07D487/02
CPC分类号： C07D471/04 , A61K31/519 , C07D471/14
摘要： Novel pyridopyrimidine derivatives which have a binding affinity for the human 5-HT6 receptor and, therefore, are useful in treating disorders responsive to antagonism of the 5-HT6 receptor such as psychosis, schizophrenia, manic depression, depression, neurological disorder, memory disorder, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease and Huntington's chorea.
摘要翻译： 对于人5-HT 6受体具有结合亲和力的新型吡啶并嘧啶衍生物，因此可用于治疗对5-HT 6受体拮抗作用的病症，例如精神病，精神分裂症，躁狂抑郁症，抑郁症，神经障碍，记忆障碍， 帕金森病，肌萎缩性侧索硬化，阿尔茨海默病和亨廷顿舞蹈病。
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公开(公告)号：US08354548B2
公开(公告)日：2013-01-15
申请号：US13025674
申请日：2011-02-11
申请人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
发明人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
IPC分类号： C07D311/00
CPC分类号： C07D311/70 , C07D405/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
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6.发明申请Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase 有权用作二酰基甘油脂肪酶抑制剂的甘氨酸色原-6-磺酰胺公开(公告)号：US20110207772A1
公开(公告)日：2011-08-25
申请号：US13025674
申请日：2011-02-11
申请人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
发明人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
IPC分类号： A61K31/4709 , C07D311/04 , A61K31/352 , C07D401/12 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/10 , A61P3/06
CPC分类号： C07D311/70 , C07D405/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
摘要翻译： 本公开一般涉及可抑制DAGLα和/或bgr的化合物; 活性，包含这些化合物的组合物和抑制DAGLα和/或bgr的方法; 活动。
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公开(公告)号：US20110207749A1
公开(公告)日：2011-08-25
申请号：US13025384
申请日：2011-02-11
申请人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
发明人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
IPC分类号： A61K31/198 , C07C311/29 , C07D239/26 , A61K31/505 , C07D277/30 , A61K31/426 , C07D311/58 , A61K31/352 , A61K31/277 , A61P3/10 , A61P3/06 , A61P25/24 , A61P25/22 , A61P25/18
CPC分类号： C07D311/70 , C07D239/26 , C07D277/28 , C07D407/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
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