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1.发明授权Glycine chroman-6-sulfonamides for use as inhibitors of diacylglycerol lipase 有权用作二酰基甘油脂肪酶抑制剂的甘氨酸色满-6-磺酰胺公开(公告)号：US08404741B2
公开(公告)日：2013-03-26
申请号：US13025384
申请日：2011-02-11
申请人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
发明人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
IPC分类号： A01N43/16 , A01N37/12 , A01N37/44 , A61K31/35 , A61K31/195 , C07D317/70 , C07C51/16 , C07C229/00
CPC分类号： C07D311/70 , C07D239/26 , C07D277/28 , C07D407/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
摘要翻译： 本公开一般涉及可抑制DAGLα和/或bgr的化合物; 活性，包含这些化合物的组合物和抑制DAGLα和/或bgr的方法; 活动。
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公开(公告)号：US20110207749A1
公开(公告)日：2011-08-25
申请号：US13025384
申请日：2011-02-11
申请人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
发明人： Louis S. Chupak , Xiaofan Zheng , Min Ding , Shuanghua Hu , Yazhong Huang , Robert G. Gentles
IPC分类号： A61K31/198 , C07C311/29 , C07D239/26 , A61K31/505 , C07D277/30 , A61K31/426 , C07D311/58 , A61K31/352 , A61K31/277 , A61P3/10 , A61P3/06 , A61P25/24 , A61P25/22 , A61P25/18
CPC分类号： C07D311/70 , C07D239/26 , C07D277/28 , C07D407/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
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公开(公告)号：US08354548B2
公开(公告)日：2013-01-15
申请号：US13025674
申请日：2011-02-11
申请人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
发明人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
IPC分类号： C07D311/00
CPC分类号： C07D311/70 , C07D405/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
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4.发明申请Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase 有权用作二酰基甘油脂肪酶抑制剂的甘氨酸色原-6-磺酰胺公开(公告)号：US20110207772A1
公开(公告)日：2011-08-25
申请号：US13025674
申请日：2011-02-11
申请人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
发明人： Shuanghua Hu , Yazhong Huang , Min Ding , Louis S. Chupak , Xiaofan Zheng , Robert G. Gentles
IPC分类号： A61K31/4709 , C07D311/04 , A61K31/352 , C07D401/12 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/10 , A61P3/06
CPC分类号： C07D311/70 , C07D405/12
摘要： The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.
摘要翻译： 本公开一般涉及可抑制DAGLα和/或bgr的化合物; 活性，包含这些化合物的组合物和抑制DAGLα和/或bgr的方法; 活动。
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公开(公告)号：US07521441B2
公开(公告)日：2009-04-21
申请号：US11745090
申请日：2007-05-07
申请人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
发明人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
IPC分类号： A61P31/00 , A61K31/407 , C07D487/00
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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公开(公告)号：US08133884B2
公开(公告)日：2012-03-13
申请号：US12434748
申请日：2009-05-04
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/04 , C07D471/08 , C07D487/08 , C07D498/08
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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公开(公告)号：US07399758B2
公开(公告)日：2008-07-15
申请号：US11507731
申请日：2006-08-22
申请人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
发明人： Nicholas A. Meanwell , Robert G. Gentles , Min Ding , John A. Bender , John F. Kadow , Piyasena Hewawasam , Thomas W. Hudyma , Xiaofan Zheng
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I的化合物，其药学上可接受的盐，组合物和使用该化合物的方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20090280083A1
公开(公告)日：2009-11-12
申请号：US12434748
申请日：2009-05-04
IPC分类号： A61K31/55 , C07D405/14 , A61K38/20 , A61K38/21 , A61K38/13 , A61P31/14 , C07D417/14 , C07D405/04
CPC分类号： C07D487/04 , C07D471/08 , C07D487/08 , C07D498/08
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
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公开(公告)号：US07547690B2
公开(公告)日：2009-06-16
申请号：US12039239
申请日：2008-02-28
申请人： Robert G. Gentles , Xiaofan Zheng , Min Ding , Yong Tu , Ying Han , Piyasena Hewawasam , John F. Kadow , John A. Bender , Kap-Sun Yeung , Katharine A. Grant-Young , Thomas W. Hudyma
发明人： Robert G. Gentles , Xiaofan Zheng , Min Ding , Yong Tu , Ying Han , Piyasena Hewawasam , John F. Kadow , John A. Bender , Kap-Sun Yeung , Katharine A. Grant-Young , Thomas W. Hudyma
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D519/00 , C07D487/04
摘要： The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物，包括药学上可接受的盐，以及使用这些化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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公开(公告)号：US20070270406A1
公开(公告)日：2007-11-22
申请号：US11745090
申请日：2007-05-07
申请人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
发明人： Robert G. Gentles , Piyasena Hewawasam , Min Ding , Carl P. Bergstrom , Scott W. Martin , Kap-Sun Yeung , Thomas W. Hudyma , Xiaofan Zheng , John A. Bender , John F. Kadow
IPC分类号： A61K31/55 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译： 本发明包括式I化合物以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。
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