公开(公告)号：US20130345417A1

公开(公告)日：2013-12-26

申请号：US13890126

申请日：2013-05-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Alexander Brandis ,  Ohad Mazor ,  Yoram Salomon ,  Hugo Scheer

IPC: C07F15/04

CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61K31/40 ,  A61K41/0071 ,  A61K41/0076 ,  A61K49/0036 ,  A61N5/0624 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F13/005 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/045

Abstract: The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO , COS , SO3 , PO3 , COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17 , 13 , and 3 of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

公开(公告)号：US11058772B2

公开(公告)日：2021-07-13

申请号：US16196537

申请日：2018-11-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor Scherz ,  Yoram Salomon ,  Arie Marcovich ,  Alexander Brandis ,  Daniel Wagner

IPC: A61K31/407 ,  A61K41/00 ,  A61K31/555 ,  A61K9/00 ,  A61K31/519 ,  A61K47/36 ,  A61N5/06

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

公开(公告)号：US20170143988A1

公开(公告)日：2017-05-25

申请号：US15425473

申请日：2017-02-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor Scherz ,  Alexander Brandis ,  Ohad Mazor ,  Yoram Salomon ,  Hugo Scheer

IPC: A61N5/06 ,  C07F15/00 ,  A61K49/00 ,  C07F3/06 ,  C07F13/00 ,  A61K41/00 ,  A61F9/00 ,  C07F1/08

CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61K31/40 ,  A61K41/0071 ,  A61K41/0076 ,  A61K49/0036 ,  A61N5/0624 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F13/005 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/045

Abstract: The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO , COS , SO3 , PO3 , COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17 , 13 , and 3 of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.