公开(公告)号：US20160287677A1

公开(公告)日：2016-10-06

申请号：US15131102

申请日：2016-04-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Hila SBERRO ,  Azita LEAVITT

IPC: A61K38/45

CPC classification number: A61K38/45 ,  A61K38/00 ,  C07K14/8107 ,  C12N9/1241 ,  C12N9/22 ,  C12Y207/07

Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

Abstract translation: 公开了分离的多肽，其包含选自SEQ ID NO：2773-5544和11089-11094的氨基酸序列，其中所述多肽具有抗微生物活性。 还公开了其用于治疗微生物感染的用途。

公开(公告)号：US20160281053A1

公开(公告)日：2016-09-29

申请号：US15030876

申请日：2014-10-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rotem SOREK ,  Hila SBERRO ,  Tamara GOLDFARB

IPC: C12N1/20 ,  C07K14/195 ,  C12N9/10 ,  C12N9/48 ,  A23C9/123 ,  C12N9/12 ,  C12N9/02 ,  C07K14/245 ,  C07K14/32 ,  C12N15/52 ,  C12N9/16 ,  C12N9/14

CPC classification number: C12N1/20 ,  A23C9/1234 ,  A23C2220/202 ,  C07K14/195 ,  C07K14/245 ,  C07K14/32 ,  C12N9/0051 ,  C12N9/1007 ,  C12N9/12 ,  C12N9/14 ,  C12N9/16 ,  C12N9/48 ,  C12N15/52 ,  C12Y108/04008 ,  C12Y201/01072 ,  C12Y207/11001 ,  C12Y301/03001 ,  C12Y304/00 ,  C12Y306/04012 ,  C12Y306/04013

Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.

Abstract translation: 提供编码BREX系统的分离的多核苷酸。 因此，提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ和pglX，pglXI，brxP，brxHI，brxHII，brxL，brxD，brxA，brxB，brxD，brxA，brxB，brxF中的至少一种的BREX系统的核酸序列 和brxE，条件是所述BREX系统不包含pglW，并且其中所述BREX系统赋予对重组表达的细菌的噬菌体抗性; 还提供了编码BREX系统的分离的多核苷酸，其包含编码包含brxC / pglY，pglZ，pglX，pglW和至少一种brxD和brxHI的BREX系统的核酸序列，并且其中所述BREX系统将重组的噬菌体抗性赋予细菌 表达相同。 还提供了赋予细菌噬菌体抗性或赋予细菌对噬菌体易感性的组合物和方法。