公开(公告)号：US20230321235A1

公开(公告)日：2023-10-12

申请号：US18020441

申请日：2021-08-11

Applicant: Yeda Research and Development Co. Ltd. ,  Ichilov Tech Ltd.

Inventor： Yair REISNER ,  Anat GLOBERSON LEVIN ,  Esther BACHAR-LUSTIG ,  Assaf LASK ,  Bar NATHANSOHN-LEVI ,  Tova WAKS ,  Galit HORN ,  Zelig ESHHAR

IPC: A61P35/00 ,  C12N5/0783 ,  A61K39/00

CPC classification number: A61K39/4611 ,  A61K39/4631 ,  A61P35/00 ,  C12N5/0636 ,  A61K2239/22 ,  C12N2510/00

Abstract: A method of generating a population of genetically modified veto cells is disclosed. The method comprising: (a) providing a population of cells comprising T cells, the T cells comprising at least 40% memory CD8+ T cells; (b) culturing the population of cells comprising T cells with an antigen or antigens under conditions which allow enrichment of tolerance-inducing antigen-specific cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being depleted of graft versus host (GVH) reactivity; and (c) transducing the cells with a polynucleotide encoding a heterologous cell surface receptor comprising a T cell receptor signaling module, thereby generating the population of genetically modified veto cells.

公开(公告)号：US20220265725A1

公开(公告)日：2022-08-25

申请号：US17736190

申请日：2022-05-04

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Rakefet SIDLIK MUSKATEL ,  Bar NATHANSOHN-LEVI

IPC: A61K35/28 ,  A61K35/17 ,  A61P35/00 ,  C12N5/0783

Abstract: A method of treating or preventing a T cell mediated autoimmune disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting immature hematopoietic cells into the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of non-GVHD inducing anti-third party cells comprising cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and capable of homing to the lymph nodes following transplantation.