公开(公告)号：US20230321235A1

公开(公告)日：2023-10-12

申请号：US18020441

申请日：2021-08-11

Applicant: Yeda Research and Development Co. Ltd. ,  Ichilov Tech Ltd.

Inventor： Yair REISNER ,  Anat GLOBERSON LEVIN ,  Esther BACHAR-LUSTIG ,  Assaf LASK ,  Bar NATHANSOHN-LEVI ,  Tova WAKS ,  Galit HORN ,  Zelig ESHHAR

IPC: A61P35/00 ,  C12N5/0783 ,  A61K39/00

CPC classification number: A61K39/4611 ,  A61K39/4631 ,  A61P35/00 ,  C12N5/0636 ,  A61K2239/22 ,  C12N2510/00

Abstract: A method of generating a population of genetically modified veto cells is disclosed. The method comprising: (a) providing a population of cells comprising T cells, the T cells comprising at least 40% memory CD8+ T cells; (b) culturing the population of cells comprising T cells with an antigen or antigens under conditions which allow enrichment of tolerance-inducing antigen-specific cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being depleted of graft versus host (GVH) reactivity; and (c) transducing the cells with a polynucleotide encoding a heterologous cell surface receptor comprising a T cell receptor signaling module, thereby generating the population of genetically modified veto cells.

公开(公告)号：US20230039904A1

公开(公告)日：2023-02-09

申请号：US17958401

申请日：2022-10-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Esther BACHAR-LUSTIG

IPC: A61K35/28 ,  A61K31/675 ,  A61K35/22 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  C12N5/00 ,  A61K31/198 ,  A61K31/255 ,  A61K31/7076 ,  A61P37/06 ,  A61P37/02 ,  A61K31/661 ,  A61K39/395

Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.

公开(公告)号：US20190328793A1

公开(公告)日：2019-10-31

申请号：US16508325

申请日：2019-07-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Esther BACHAR-LUSTIG

IPC: A61K35/28 ,  A61K35/38 ,  A61K31/198 ,  A61K31/255 ,  A61K39/395 ,  A61K31/661 ,  A61K35/42 ,  A61K35/407 ,  A61K35/39 ,  C12N5/00 ,  A61K35/36 ,  A61K35/34 ,  A61K35/22 ,  A61K31/675 ,  A61K31/7076

Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoietic cells, wherein the T cell depleted immature hematopoietic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject; and subsequently (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per kilogram body weight, thereby treating the subject.

公开(公告)号：US20230256028A1

公开(公告)日：2023-08-17

申请号：US18137449

申请日：2023-04-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Carmit HILLEL-KARNIEL ,  Chava ROSEN ,  Esther BACHAR-LUSTIG ,  Elias SHEZEN

IPC: A61K35/42 ,  A61P11/00 ,  A61K9/00 ,  A61K35/28

CPC classification number: A61K35/42 ,  A61P11/00 ,  A61K9/0019 ,  A61K35/28

Abstract: A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.

公开(公告)号：US20220080034A1

公开(公告)日：2022-03-17

申请号：US17531897

申请日：2021-11-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/00 ,  A61K35/17 ,  C12N5/078 ,  C12N5/0783 ,  A61P31/00 ,  A61P35/04 ,  A61K39/395 ,  C07K16/28

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20190316087A1

公开(公告)日：2019-10-17

申请号：US16313486

申请日：2017-06-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Rotem GIDRON BUDOVSKY ,  Esther BACHAR-LUSTIG ,  Assaf LASK ,  Sivan KAGAN

IPC: C12N5/0783 ,  C12N5/00 ,  A61K35/17 ,  A61K39/00

Abstract: A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.

公开(公告)号：US20180207272A1

公开(公告)日：2018-07-26

申请号：US15744905

申请日：2016-07-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/395 ,  C07K16/28 ,  A61P31/00 ,  A61P35/04

CPC classification number: A61K39/001 ,  A61K35/17 ,  A61K39/39566 ,  A61K2035/122 ,  A61K2039/5158 ,  A61P31/00 ,  A61P35/04 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0648 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  Y02A50/467

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20240325456A1

公开(公告)日：2024-10-03

申请号：US18736635

申请日：2024-06-07

Applicant: Yeda Research and Development Co. Ltd. ,  Board of Regents, The University of Texas System

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Ran ORGAD ,  Irit MILMAN KRENTSIS ,  Xiaohua SU ,  Raj Kumar YADAV ,  Yangxi ZHENG

IPC: A61K35/42 ,  C12N5/071

CPC classification number: A61K35/42 ,  C12N5/0688 ,  C12N2501/11 ,  C12N2501/165 ,  C12N2501/727 ,  C12N2509/00

Abstract: Multipotent lung progenitor cells for lung regeneration are provided. Accordingly, there are provided methods of expanding in culture an isolated population of pulmonary cells, methods of qualifying suitability of an isolated population of pulmonary cells for administration to a subject in need thereof, and methods of generating an isolated population of pulmonary cells comprising selecting a cell population being double positive for expression of epithelial and endothelial cell markers. Also provided are isolated populations of pulmonary cells, pharmaceutical compositions comprising same and uses of same.

公开(公告)号：US20240148845A1

公开(公告)日：2024-05-09

申请号：US18515358

申请日：2023-11-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/00 ,  A61K35/17 ,  A61K39/395 ,  A61P31/00 ,  A61P35/04 ,  C07K16/28 ,  C12N5/078 ,  C12N5/0783

CPC classification number: A61K39/001 ,  A61K35/17 ,  A61K39/39566 ,  A61P31/00 ,  A61P35/04 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0648 ,  A61K2035/122 ,  A61K2039/5158 ,  C12N2501/2315 ,  C12N2501/2321 ,  Y02A50/30

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20230398214A1

公开(公告)日：2023-12-14

申请号：US17633294

申请日：2020-08-06

Applicant: Yeda Research and Development Co. Ltd. ,  Board of Regents, The University of Texas System

Inventor： Yair REISNER ,  Esther BACHAR-LUSTIG ,  Assaf LASK ,  Noga OR-GEVA ,  Rotem GIDRON BUDOVSKY ,  Rakefet SIDLIK MUSKATEL

IPC: A61K39/00 ,  C12N5/0783 ,  A61K31/664 ,  A61P37/06

CPC classification number: A61K39/4622 ,  C12N5/0636 ,  A61K39/4633 ,  A61K39/4614 ,  A61K39/464411 ,  A61K39/46444 ,  A61K39/464838 ,  A61K31/664 ,  A61P37/06 ,  A61K39/464429 ,  A61K39/4621 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2502/1121

Abstract: Methods of generating an isolated population of non-graft versus host disease (GVHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation, are disclosed. Cells generated by the methods, pharmaceutical compositions and methods of treatment are also disclosed.