公开(公告)号：US20150290233A1

公开(公告)日：2015-10-15

申请号：US14432520

申请日：2013-11-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef Yarden ,  Nir Ben-Chetrit

IPC: A61K31/7048 ,  A61K31/353 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/12 ,  G01N33/574 ,  A61K31/155 ,  A61K31/4709 ,  A61K31/235 ,  A61K31/05 ,  A61K39/00 ,  A61K45/06 ,  A61K31/7032

CPC classification number: A61K31/7048 ,  A61K31/05 ,  A61K31/12 ,  A61K31/155 ,  A61K31/216 ,  A61K31/235 ,  A61K31/353 ,  A61K31/366 ,  A61K31/4709 ,  A61K31/7032 ,  A61K31/7034 ,  A61K31/704 ,  A61K38/179 ,  A61K39/0011 ,  A61K45/06 ,  C07K16/30 ,  G01N33/57415 ,  A61K2300/00

Abstract: A method of preventing tumor metastasis with the proviso that the tumor is not glioma is provided. The method comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2), thereby preventing tumor metastasis. Also, provided is a method of treating cancer. The method comprising, administering to a subject in need thereof a therapeutically effective amount of an inhibitor of synaptojanin 2 (SYNJ2) and an inhibitor of a cell surface receptor associated with an onset or progression of cancer, thereby treating cancer.

Abstract translation: 提供了一种预防肿瘤转移的方法，条件是肿瘤不是神经胶质瘤。 所述方法包括向有需要的受试者施用治疗有效量的突触纲2（SYNJ2）抑制剂，从而防止肿瘤转移。 另外，提供了治疗癌症的方法。 该方法包括向有需要的受试者施用治疗有效量的突触纲2（SYNJ2）抑制剂和与癌症发病或进展相关的细胞表面受体的抑制剂，从而治疗癌症。

公开(公告)号：US10040868B2

公开(公告)日：2018-08-07

申请号：US15328036

申请日：2014-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit Sagi ,  Moran Grossman ,  Nir Ben-Chetrit

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/40 ,  A61K45/06 ,  A61K33/24

Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.