公开(公告)号：US20240390282A1

公开(公告)日：2024-11-28

申请号：US18792590

申请日：2024-08-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Yaara OPPENHEIMER-SHAANAN ,  Weifeng LIN ,  Monika KLUZEK

IPC: A61K9/127 ,  A61K31/352 ,  A61K31/635 ,  A61P31/04

Abstract: Liposomes, and pharmaceutical compositions comprising same, for use in treating biofilm in a subject in need thereof are disclosed herein. The liposomes comprise a bilayer-forming lipid; a polymer-lipid conjugate having the general formula I, as described and defined in the specification; a positively-charged lipidic agent, incorporated within a lipid bilayer and/or on a surface of the liposome; and a therapeutically active agent, bound to a surface of the liposome and/or within a lipid bilayer and/or core of the liposome.

公开(公告)号：US20210144999A1

公开(公告)日：2021-05-20

申请号：US16629572

申请日：2018-07-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.

Inventor： Ilana KOLODKIN-GAL ,  Yaara OPPENHEIMER-SHAANAN ,  Ariel OGRAN-NACHMAN ,  Michael MEIJLER ,  Eliane Hadas YARDENI

IPC: A01N43/16 ,  A01N37/38 ,  A01N33/04 ,  C07C231/24 ,  C12N1/38

Abstract: The present invention provides anti-microbial compositions comprising a hydroxycinnamic acid and related conjugates, analogues and derivatives, and methods of use thereof for enhancing production of anti-microbial agents in bacteria as well as for protecting plants from microbial infection.