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公开(公告)号：US20210378960A1
公开(公告)日：2021-12-09
申请号：US17406168
申请日：2021-08-19
发明人： Jacob KLEIN , Ronit GOLDBERG , Jasmine SEROR
IPC分类号： A61K9/127 , A61K9/00 , A61K47/32 , A61K47/10 , A61K47/36 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , B65D35/00 , B65D75/36
摘要： Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
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公开(公告)号：US20230301915A1
公开(公告)日：2023-09-28
申请号：US18202981
申请日：2023-05-29
发明人： Jacob KLEIN , Ronit GOLDBERG , Weifeng LIN
CPC分类号： A61K9/1273 , A61P19/02 , A61K9/0019
摘要： A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises:
a) at least one bilayer-forming lipid;
b) a polymeric compound having the general formula I:
wherein m, n, L, X, Y, and Z are as defined herein; and
c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.-
公开(公告)号：US20170298297A1
公开(公告)日：2017-10-19
申请号：US15516407
申请日：2015-10-01
发明人： Jacob KLEIN , Ronit GOLDBERG , Weifeng LIN , Sabrina JAHN
摘要： A method of inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and a method of inhibiting biofilm formation on a surface of a substrate are disclosed herein. The methods comprise comprising contacting the substrate with a composition which comprises liposomes. Further disclosed herein is a composition comprising liposomes, identified for use in inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and/or inhibiting biofilm formation on a surface of a substrate. Further disclosed are articles comprising a substrate and a composition described herein being applied on a surface of the substrate, and a method of treating keratitis in a contact lens-wearing subject, by rinsing and/or immersing a contact lens in a solution comprising liposomes.
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4.发明公开公开(公告)号：US20240165027A1
公开(公告)日：2024-05-23
申请号：US18424973
申请日：2024-01-29
发明人： Jacob KLEIN , Ronit GOLDBERG , Jasmine SEROR
IPC分类号： A61K9/127 , A61K9/00 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , A61K47/10 , A61K47/32 , A61K47/36 , B65D35/00 , B65D75/36
CPC分类号： A61K9/127 , A61K9/0048 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , A61K47/10 , A61K47/32 , A61K47/36 , B65D35/00 , B65D75/36
摘要： Formulations (e.g., solutions) comprising one or more water-soluble polymer(s), liposomes, and an aqueous carrier, are provided. The provided solutions are useful for rinsing, and/or immersing therein, a contact lens and/or in the treatment of ocular discomfort, for example, an ocular discomfort associated with a contact lens. Also provided are kits comprising the solution and a contact lens; articles-of-manufacturing comprising the solution and configured for dispending the solution; and methods utilizing the solution.
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公开(公告)号：US20210186876A1
公开(公告)日：2021-06-24
申请号：US17190537
申请日：2021-03-03
发明人： Jacob KLEIN , Ronit GOLDBERG , Jasmine SEROR , Weifeng LIN , Reut MASHIACH
IPC分类号： A61K9/127 , A61K9/00 , A61K47/32 , A61K47/10 , A61K47/36 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , B65D35/00 , B65D75/36
摘要： A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
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公开(公告)号：US20180161481A1
公开(公告)日：2018-06-14
申请号：US15890504
申请日：2018-02-07
发明人： Jacob KLEIN , Ronit GOLDBERG , Noa IUSTER , Raya SORKIN
CPC分类号： A61L27/52 , A61K9/0019 , A61K9/0024 , A61L27/34 , A61L27/44 , A61L2300/626 , A61L2400/10 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , C08F2/10 , C08F2/44 , C09D133/066
摘要： Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
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公开(公告)号：US20170128365A1
公开(公告)日：2017-05-11
申请号：US15319005
申请日：2015-06-15
发明人： Jacob KLEIN , Ronit GOLDBERG , Jasmine SEROR , Weifeng LIN , Reut MASHIACH
IPC分类号： A61K9/127 , A61K9/00 , A61K31/728
CPC分类号： A61K9/127 , A61K9/0048 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , A61K47/10 , A61K47/32 , A61K47/36 , B65D35/00 , B65D75/36
摘要： A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
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公开(公告)号：US20160175488A1
公开(公告)日：2016-06-23
申请号：US14902574
申请日：2014-07-03
发明人： Jacob KLEIN , Ronit GOLDBERG , Noa IUSTER , Raya SORKIN
CPC分类号： A61L27/52 , A61K9/0019 , A61K9/0024 , A61L27/34 , A61L27/44 , A61L2300/626 , A61L2400/10 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , C08F2/10 , C08F2/44 , C09D133/066
摘要： Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
摘要翻译： 公开了与纯水凝胶或含有水凝胶的复合材料相比，其中分散有水凝胶和脂质体的水凝胶和复合材料以及与其混合的水凝胶和脂质体以及使用该水凝胶和脂质体的方法。
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公开(公告)号：US20230151129A1
公开(公告)日：2023-05-18
申请号：US17872050
申请日：2022-07-25
发明人： Jacob KLEIN , Weifeng LIN , Ronit GOLDBERG
CPC分类号： C08F130/02 , A61K9/08 , A61K9/0051 , A61K9/1273 , A61P19/02 , C07F9/106 , A61K9/0019 , A61K47/6909 , C08F2438/01
摘要： A polymeric compound is disclosed herein, having the general formula I:
wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.-
公开(公告)号：US20200332033A1
公开(公告)日：2020-10-22
申请号：US16919138
申请日：2020-07-02
发明人： Jacob KLEIN , Weifeng LIN , Ronit GOLDBERG
摘要： A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
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