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公开(公告)号：US20250043048A1
公开(公告)日：2025-02-06
申请号：US18912658
申请日：2024-10-11
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Weifeng LIN , Ronit GOLDBERG
Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
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公开(公告)号：US20210186876A1
公开(公告)日：2021-06-24
申请号：US17190537
申请日：2021-03-03
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Jasmine SEROR , Weifeng LIN , Reut MASHIACH
IPC: A61K9/127 , A61K9/00 , A61K47/32 , A61K47/10 , A61K47/36 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , B65D35/00 , B65D75/36
Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
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公开(公告)号：US20170128365A1
公开(公告)日：2017-05-11
申请号：US15319005
申请日：2015-06-15
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Jasmine SEROR , Weifeng LIN , Reut MASHIACH
IPC: A61K9/127 , A61K9/00 , A61K31/728
CPC classification number: A61K9/127 , A61K9/0048 , A61K9/08 , A61K31/728 , A61K31/77 , A61K31/79 , A61K47/10 , A61K47/32 , A61K47/36 , B65D35/00 , B65D75/36
Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.
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公开(公告)号：US20240390282A1
公开(公告)日：2024-11-28
申请号：US18792590
申请日：2024-08-02
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Yaara OPPENHEIMER-SHAANAN , Weifeng LIN , Monika KLUZEK
IPC: A61K9/127 , A61K31/352 , A61K31/635 , A61P31/04
Abstract: Liposomes, and pharmaceutical compositions comprising same, for use in treating biofilm in a subject in need thereof are disclosed herein. The liposomes comprise a bilayer-forming lipid; a polymer-lipid conjugate having the general formula I, as described and defined in the specification; a positively-charged lipidic agent, incorporated within a lipid bilayer and/or on a surface of the liposome; and a therapeutically active agent, bound to a surface of the liposome and/or within a lipid bilayer and/or core of the liposome.
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Patent Agency Ranking
公开(公告)号：US20230301915A1
公开(公告)日：2023-09-28
申请号：US18202981
申请日：2023-05-29
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Weifeng LIN
CPC classification number: A61K9/1273 , A61P19/02 , A61K9/0019
Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises:
a) at least one bilayer-forming lipid;
b) a polymeric compound having the general formula I:
wherein m, n, L, X, Y, and Z are as defined herein; and
c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.-
公开(公告)号：US20170298297A1
公开(公告)日：2017-10-19
申请号：US15516407
申请日：2015-10-01
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Weifeng LIN , Sabrina JAHN
CPC classification number: C11D3/0078 , A01N25/26 , A61K31/78 , C11D3/222 , C11D3/225 , C11D3/365 , G02C7/04
Abstract: A method of inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and a method of inhibiting biofilm formation on a surface of a substrate are disclosed herein. The methods comprise comprising contacting the substrate with a composition which comprises liposomes. Further disclosed herein is a composition comprising liposomes, identified for use in inhibiting adsorption of a biofouling-promoting agent on a surface of a substrate and/or inhibiting biofilm formation on a surface of a substrate. Further disclosed are articles comprising a substrate and a composition described herein being applied on a surface of the substrate, and a method of treating keratitis in a contact lens-wearing subject, by rinsing and/or immersing a contact lens in a solution comprising liposomes.
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公开(公告)号：US20230151129A1
公开(公告)日：2023-05-18
申请号：US17872050
申请日：2022-07-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Weifeng LIN , Ronit GOLDBERG
CPC classification number: C08F130/02 , A61K9/08 , A61K9/0051 , A61K9/1273 , A61P19/02 , C07F9/106 , A61K9/0019 , A61K47/6909 , C08F2438/01
Abstract: A polymeric compound is disclosed herein, having the general formula I:
wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.-
公开(公告)号：US20200332033A1
公开(公告)日：2020-10-22
申请号：US16919138
申请日：2020-07-02
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Weifeng LIN , Ronit GOLDBERG
Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
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公开(公告)号：US20190002609A1
公开(公告)日：2019-01-03
申请号：US16064498
申请日：2016-12-22
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Weifeng LIN , Ronit GOLDBERG
IPC: C08F130/02 , A61K9/127 , A61K9/00 , C07F9/10
CPC classification number: C08F130/02 , A61K9/0019 , A61K9/0051 , A61K9/08 , A61K9/1273 , A61K47/6909 , A61P19/02 , C07F9/106 , C08F2438/01
Abstract: A polymeric compound is disclosed herein, having the general formula I: wherein m, n, X, Y, Z and L are as defined herein. Further disclosed herein are lipid bilayers comprising at least one bilayer-forming lipid and the aforementioned polymeric compound, and liposomes comprising such a bilayer, as well as methods, uses and compositions utilizing such bilayers and/or liposomes for reducing a friction coefficient of a surface and/or for inhibiting biofilm formation.
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