公开(公告)号：US20170087190A1

公开(公告)日：2017-03-30

申请号：US15379528

申请日：2016-12-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael WALKER ,  Yoav SOEN ,  Revital SHARIVKIN

IPC: A61K35/39 ,  G01N33/569 ,  C12N5/071

CPC classification number: A61K35/39 ,  C12N5/0676 ,  C12N2501/415 ,  C12N2501/50 ,  C12N2501/505 ,  C12N2501/585 ,  C12N2501/599 ,  G01N33/56966 ,  G01N2333/70596 ,  G01N2333/71 ,  G01N2500/10

Abstract: Methods of isolating distinct specific cell types within mixed populations of cells. Methods of isolating specific cell types among pancreatic cells, particularly from human islets of Langerhans. Markers and combinations thereof for use in methods of isolating insulin producing islet beta cells for treatment of diabetes.

公开(公告)号：US20230248779A1

公开(公告)日：2023-08-10

申请号：US18137455

申请日：2023-04-21

Applicant: Kadimastem Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Kfir MOLAKANDOV ,  Neta LAVON ,  Avital BECK ,  Michel REVEL ,  Ofer ELHANANI ,  Yoav SOEN ,  Michael WALKER ,  Arye HASSON

IPC: A61K35/39 ,  C12N5/071 ,  A61P5/50 ,  A61P3/10

CPC classification number: A61K35/39 ,  C12N5/0676 ,  A61P5/50 ,  A61P3/10 ,  C12N2506/45 ,  C12N2500/38 ,  C12N2500/34 ,  C12N2506/02 ,  C12N2501/599 ,  C12N2500/25

Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.

公开(公告)号：US20170344883A1

公开(公告)日：2017-11-30

申请号：US15607695

申请日：2017-05-30

Applicant: Yeda Research and Development Co. Ltd. ,  Technion Research & Development Foundation Limited

Inventor： Yoav SOEN ,  Hallel SCHREIER ,  Naama BRENNER

IPC: G06N3/08 ,  G06N3/04

CPC classification number: G16B5/00 ,  G16B99/00

Abstract: There is provided a method comprising: receiving a graph comprising nodes with directional edges each associated with a variable weight representing an interaction strength of the respective direction edge adjustable according to a respective range; calculating a current global value defined by a function of the variable weights of the directional edges; calculating a mismatch between the current global value and a desired global value, wherein multiple different combinations of assigned variable weights of the directional edges are associated with the desired global value within the tolerance requirement; determining when the mismatch is within a tolerance requirement representing desired global values; and one of: randomly adjusting the variable weights of the directional edges within the respective range, and iterating the calculating the mismatch and determining when the mismatch is not within the tolerance requirement, and outputting determined values for the variable weights when the mismatch is within the tolerance requirement.