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11 条记录 (耗时 0.028 秒)

    Process and systems for recovery of peptides
    1.
    发明授权
    Process and systems for recovery of peptides 有权
    用于回收肽的方法和系统

    公开(公告)号：US07696311B2

    公开(公告)日：2010-04-13

    申请号：US11021845

    申请日：2004-12-23

    申请人： Yeun-Kwei Han ,  Hiralal N. Khatri ,  Robert J. Topping

    发明人： Yeun-Kwei Han ,  Hiralal N. Khatri ,  Robert J. Topping

    IPC分类号： A61K38/00

    CPC分类号： C07K14/005 ,  C07K1/30 ,  C12N2740/16122 ,  Y02P20/55

    摘要： The invention provides methods of obtaining a peptide that include steps of synthesizing a peptide intermediate having one or more side chain protecting groups; providing a solvent to the peptide intermediate to form a peptide intermediate composition; and providing a precipitating agent in an amount sufficient to precipitate the peptide intermediate from the peptide intermediate composition, wherein the precipitating agent is an alcohol having three or more carbon atoms. Also provided are methods for precipitating peptides, methods for concentration peptides, and methods for filtering peptides.

    摘要翻译： 本发明提供了获得肽的方法，其包括合成具有一个或多个侧链保护基团的肽中间体的步骤; 向所述肽中间体提供溶剂以形成肽中间体组合物; 并提供足以使肽中间体从肽中间体组合物沉淀的沉淀剂，其中沉淀剂是具有三个或更多个碳原子的醇。 还提供了沉淀肽的方法，浓缩肽的方法和肽过滤方法。

    Hydraulic tubing fitting seal
    8.
    发明申请
    Hydraulic tubing fitting seal 审中-公开
    液压油管接头密封

    公开(公告)号：US20080272550A1

    公开(公告)日：2008-11-06

    申请号：US12151221

    申请日：2008-05-02

    申请人： Robert J. Topping

    发明人： Robert J. Topping

    IPC分类号： F16L23/22

    CPC分类号： F16L19/041

    摘要： A seal for a flared end fitting, wherein the fitting includes a male portion having a tapered end, a female portion having a coordinated shape to the male portion, and a flow passage axially disposed in both female and male portions, the seal comprising: a frustoconical portion having an inner end and an outer end, wherein the inner end is circumferentially attached to one end of a cylindrical portion having two ends and coaxially disposed about the cylindrical portion, the cylindrical portion forms a flow passage through the seal, the frustoconical and cylindrical portions form a cavity that fits on the tapered end of the male portion of the fitting, and the cylindrical portion of the seal fits into the flow passage of the male portion of the fitting. A method of sealing a flared end fitting.

    摘要翻译： 用于扩口端配件的密封件，其中所述配件包括具有锥形端部的凸形部分，具有与所述阳性部分相配的形状的阴部分，以及轴向设置在阴部分和阴部分中的流动通道，所述密封件包括： 截头圆锥形部分具有内端和外端，其中内端周向地附接到具有两端的圆柱形部分的一端并且围绕圆柱形部分同轴设置，圆柱形部分形成通过密封件的流动通道，截头圆锥形和 圆筒部形成配合在配件的阳部的锥形端部的空腔，密封件的圆筒部嵌入配件的阳部的流路。 密封扩口端配件的方法。

    Aromatic sulfonated ketals
    9.
    发明申请
    Aromatic sulfonated ketals 审中-公开
    芳香磺化缩酮

    公开(公告)号：US20080161564A1

    公开(公告)日：2008-07-03

    申请号：US12004204

    申请日：2007-12-20

    申请人： Mark A. Schwindt ,  Robert J. Topping ,  Charles E. Tucker

    发明人： Mark A. Schwindt ,  Robert J. Topping ,  Charles E. Tucker

    IPC分类号： C07D241/10

    CPC分类号： C07D319/08 ,  C07D241/20

    摘要： The present invention advantageously provides ketal functional compounds that can be strong electrophiles under conditions compatible with ketal groups, are stable, crystalline solids at room temperature, and are much safer to handle than ketal iodides. The present invention accomplishes by incorporating aromatic sulfonyl moieties into ketal functional materials. The compounds are useful starting materials or intermediates in the synthesis of more complex organic molecules.

    摘要翻译： 本发明有利地提供缩酮官能化合物，其在与缩酮基团相容的条件下可以是强亲电体，在室温下是稳定的，结晶固体，并且比酮碘化物更安全。 本发明通过将芳香族磺酰部分引入缩酮功能材料来实现。 这些化合物是合成更复杂有机分子的有用起始原料或中间体。

    Reduction methodologies for converting ketal acids, salts, and esters to ketal alcohols
    10.
    发明申请
    Reduction methodologies for converting ketal acids, salts, and esters to ketal alcohols 审中-公开
    将缩酮酸，盐和酯转化为缩酮醇的还原方法

    公开(公告)号：US20080161563A1

    公开(公告)日：2008-07-03

    申请号：US12004191

    申请日：2007-12-20

    申请人： Robert J. Topping ,  Charles E. Tucker ,  Gregory P. Withers

    发明人： Robert J. Topping ,  Charles E. Tucker ,  Gregory P. Withers

    IPC分类号： C07D241/20 ,  C07D319/08

    CPC分类号： C07D319/08 ,  C07D241/26

    摘要： The present invention relates to methods of reducing ketal acids, salts and esters to form corresponding ketal alcohols. More particularly, the reducing methods convert the ketal acids, salts, or esters to ketal alcohols by using a reducing agent that comprises a hydride that comprises one or more alkoxy moieties. The ketal alcohol is prepared in a hydrophobic reagent. This is purified by washing the hydrophobic reagent with one or more water washes. Because the ketal alcohol has some water solubility, the water washes are back-extracted with a hydrophobic solvent to recover additional ketal alcohol from such one or more water washes. The alcohol products are useful in many applications such as intermediates in the synthesis of pharmacologically important molecules.

    摘要翻译： 本发明涉及还原缩酮酸，盐和酯以形成相应的缩酮醇的方法。 更具体地，还原方法通过使用包含包含一个或多个烷氧基部分的氢化物的还原剂将缩酮酸，盐或酯转化为缩酮醇。 缩酮醇在疏水性试剂中制备。 这通过用一次或多次洗涤水洗涤疏水性试剂来纯化。 因为缩酮醇具有一定的水溶性，所以用疏水性溶剂反冲洗水洗，从这种一次或多次水洗中回收另外的缩酮醇。 醇产物在许多应用中是有用的，例如合成药理学重要分子的中间体。