公开(公告)号：US07122626B2

公开(公告)日：2006-10-17

申请号：US10132887

申请日：2002-04-24

申请人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Roland W. Bürli ,  Jacob A. Kaizerman ,  Amanda E. Martin ,  Brie Cadman

发明人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Roland W. Bürli ,  Jacob A. Kaizerman ,  Amanda E. Martin ,  Brie Cadman

IPC分类号： C07K5/10

CPC分类号： C07D409/14

摘要： Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds. A representative thienyl compound has the structure

公开(公告)号：US07498405B2

公开(公告)日：2009-03-03

申请号：US11446598

申请日：2006-06-02

申请人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Roland W. Burli ,  Jacob A. Kaizerman ,  Amanda E. Martin ,  Brie Cadman

发明人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Roland W. Burli ,  Jacob A. Kaizerman ,  Amanda E. Martin ,  Brie Cadman

IPC分类号： C07K5/10

CPC分类号： C07D409/14

摘要： Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds. A representative thienyl compound has the structure

摘要翻译： 卤素取代的噻吩基化合物表现出作为核酸（特别是双链DNA）粘合剂和抗生素化合物的潜力。 代表性的噻吩基化合物具有结构

公开(公告)号：US06555693B2

公开(公告)日：2003-04-29

申请号：US09808729

申请日：2001-03-14

申请人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Heinz E. Moser ,  Roland W. Bürli

发明人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Heinz E. Moser ,  Roland W. Bürli

IPC分类号： C07D23102

CPC分类号： C07K14/47 ,  A61K31/7052 ,  A61K38/00 ,  C07D417/14 ,  Y02A50/475 ,  Y02A50/481

摘要： Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.

公开(公告)号：US07078536B2

公开(公告)日：2006-07-18

申请号：US10278870

申请日：2002-10-22

申请人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Heinz E. Moser ,  Roland W. Bürli

发明人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Heinz E. Moser ,  Roland W. Bürli

IPC分类号： C07D409/00 ,  C07D413/00 ,  A01N43/36

CPC分类号： C07D417/14 ,  A61K31/4178 ,  A61K31/7052 ,  Y02A50/475 ,  Y02A50/481

摘要： Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.

公开(公告)号：US07301037B2

公开(公告)日：2007-11-27

申请号：US11487164

申请日：2006-07-14

申请人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Heinz E. Moser ,  Roland W. Burli

发明人： Yigong Ge ,  Matthew J. Taylor ,  Eldon E. Baird ,  Heinz E. Moser ,  Roland W. Burli

IPC分类号： C07D209/56 ,  C07D409/00 ,  C07D413/00 ,  A01N57/18 ,  A01N43/06 ,  A01N43/36 ,  A61K31/535

CPC分类号： C07K14/47 ,  A61K31/7052 ,  A61K38/00 ,  C07D417/14 ,  Y02A50/475 ,  Y02A50/481

摘要： Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.

摘要翻译： 提供的带电化合物包含一个或多个局部正电荷的区域，包含这种化合物的组合物，合成这些化合物的方法，筛选这些化合物以鉴定具有抗感染活性的化合物的方法，以及使用这些化合物来预防或抑制 感染。 这些化合物和含有它们的组合物具有多种应用，包括在人类和动物医学​​和农业中的应用。

公开(公告)号：US20060287247A1

公开(公告)日：2006-12-21

申请号：US11446598

申请日：2006-06-02

申请人： Yigong Ge ,  Matthew Taylor ,  Eldon Baird ,  Roland Burli ,  Jacob Kaizerman ,  Amanda Martin ,  Brie Cadman

发明人： Yigong Ge ,  Matthew Taylor ,  Eldon Baird ,  Roland Burli ,  Jacob Kaizerman ,  Amanda Martin ,  Brie Cadman

IPC分类号： A61K38/06 ,  A61K38/05 ,  A61K38/04 ,  C07K5/06 ,  C07K5/04 ,  C07D409/14

CPC分类号： C07D409/14

摘要： Halogen substituted thienyl compounds exhibit potential as nucleic acid (especially double stranded DNA) binders and as antibiotic compounds. A representative thienyl compound has the structure

公开(公告)号：US20050065141A1

公开(公告)日：2005-03-24

申请号：US10910243

申请日：2004-08-02

申请人： Debra Odink ,  Paul Truex ,  Yigong Ge

发明人： Debra Odink ,  Paul Truex ,  Yigong Ge

IPC分类号： A61K31/407

CPC分类号： A61K31/407

摘要： The present invention provides carbapenems to treat or prevent pulmonary infections, particularly in patients with cystic fibrosis, pneumonia, ventilator associated pneumonia, bronchitis or bronchiectstasis, pharmaceutical compositions of these carbapenems and methods of administering these carbapenems to treat or prevent pulmonary infections.

摘要翻译： 本发明提供了治疗或预防肺部感染的碳青霉烯类，特别是囊性纤维化，肺炎，呼吸机相关性肺炎，支气管炎或支气管扩张症的患者，这些碳青霉烯类药物组合物以及施用这些碳青霉烯类药物治疗或预防肺部感染的方法。

公开(公告)号：US6162619A

公开(公告)日：2000-12-19

申请号：US81686

申请日：1998-05-20

申请人： Sanjoy Biswas ,  Alexander Bryant ,  Yigong Ge ,  David John Holmes ,  Karen A Ingraham ,  Deborah Dee Jaworski ,  Andrea Marra ,  Lisa Kathleen Shilling ,  John P. Throup ,  Min Wang ,  Nicola Gail Wallis ,  Magdalena Zalacain

发明人： Sanjoy Biswas ,  Alexander Bryant ,  Yigong Ge ,  David John Holmes ,  Karen A Ingraham ,  Deborah Dee Jaworski ,  Andrea Marra ,  Lisa Kathleen Shilling ,  John P. Throup ,  Min Wang ,  Nicola Gail Wallis ,  Magdalena Zalacain

IPC分类号： C12N9/12 ,  C12N15/31 ,  C07H21/00 ,  C12N15/52 ,  C12N15/62 ,  C12N15/63

CPC分类号： C12N9/1205

摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.

摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。

公开(公告)号：US20120010180A1

公开(公告)日：2012-01-12

申请号：US13235874

申请日：2011-09-19

申请人： Mahendra G. Dedhiya ,  Yigong Ge ,  Chun (Vernon) Jiang

发明人： Mahendra G. Dedhiya ,  Yigong Ge ,  Chun (Vernon) Jiang

IPC分类号： A61K31/546 ,  A61P31/04

CPC分类号： A61K31/675 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/546 ,  A61K47/12 ,  A61K47/183

摘要： The present invention relates to new dosage forms of cephem compounds, useful for the treatment of bacterial infections. The dosage forms are stable, exhibit enhanced solubility, and are particularly well suited for, e.g., parenteral administration.

摘要翻译： 本发明涉及可用于治疗细菌感染的头孢烯化合物的新剂型。 剂型是稳定的，表现出增强的溶解性，并且特别适用于例如肠胃外给药。

公开(公告)号：US20090082326A1

公开(公告)日：2009-03-26

申请号：US12233662

申请日：2008-09-19

申请人： Mahendra Dedhiya ,  Yigong Ge

发明人： Mahendra Dedhiya ,  Yigong Ge

IPC分类号： A61K31/397 ,  A61P31/04

CPC分类号： A61K31/675 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/546 ,  A61K47/12 ,  A61K47/183

摘要： The present invention relates to new dosage forms of cephem compounds, useful for the treatment of bacterial infections. The dosage forms are stable, exhibit enhanced solubility, and are particularly well suited for, e.g., parenteral administration.

摘要翻译： 本发明涉及可用于治疗细菌感染的头孢烯化合物的新剂型。 剂型是稳定的，表现出增强的溶解性，并且特别适用于例如肠胃外给药。