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公开(公告)号：US06303771B1
公开(公告)日：2001-10-16
申请号：US09080643
申请日：1998-05-18
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
IPC分类号： C12N1531
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US6162619A
公开(公告)日：2000-12-19
申请号：US81686
申请日：1998-05-20
申请人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , Yigong Ge , David John Holmes , Karen A Ingraham , Deborah Dee Jaworski , Andrea Marra , Lisa Kathleen Shilling , John P. Throup , Min Wang , Nicola Gail Wallis , Magdalena Zalacain
CPC分类号： C12N9/1205
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US6043071A
公开(公告)日：2000-03-28
申请号：US971782
申请日：1997-11-17
申请人： Christine DeBouck , Deborah Dee Jaworski , Jeffrey L Mooney , Lisa Kathleen Shilling , Nicola Gail Wallis , Min Wang , Yi Yi Zhong
发明人： Christine DeBouck , Deborah Dee Jaworski , Jeffrey L Mooney , Lisa Kathleen Shilling , Nicola Gail Wallis , Min Wang , Yi Yi Zhong
IPC分类号： G01N33/50 , A61K31/70 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N15/00 , C12N15/09 , C12N15/31 , C12P21/08 , C12Q1/68 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569 , C07H21/04 , C12N1/20
CPC分类号： C12N9/1241 , C07K14/315 , A61K38/00 , A61K39/00
摘要： The invention provides GlmU polypeptides and polynucleotides encoding GlmU polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing GlmU polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了GlmU多肽和编码GlmU多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用GlmU多肽筛选抗菌化合物的方法。
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公开(公告)号：US5891672A
公开(公告)日：1999-04-06
申请号：US977554
申请日：1997-11-25
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/43 , A61K39/085 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/02 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P43/00 , C07H21/04 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/78 , C12N9/86 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/445 , C07H21/00 , C12N15/63
CPC分类号： C12Y305/04025 , C12N9/78 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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5.发明授权Phenylalanyl tRNA synthetase alpha subunit polynucleotides from streptococcus pneumoniae 失效来自肺炎链球菌的苯丙氨酰tRNA合成酶α亚基多核苷酸
公开(公告)号：US5871989A
公开(公告)日：1999-02-16
申请号：US953041
申请日：1997-10-17
CPC分类号： C12N9/93 , C07K14/315 , C07K14/3153 , G01N33/56944 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides pheS (alpha) polypeptides and DNA (RNA) encoding pheS (alpha) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pheS (alpha) polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了pheS（α）多肽和编码pheS（α）多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用pheS（α）多肽筛选抗菌化合物的方法。
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公开(公告)号：US07202071B2
公开(公告)日：2007-04-10
申请号：US10437581
申请日：2003-05-14
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06660520B2
公开(公告)日：2003-12-09
申请号：US09092218
申请日：1998-06-05
申请人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Lisa Kathleen Shilling , Min Wang , Edwina Imogen Wilding
发明人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Lisa Kathleen Shilling , Min Wang , Edwina Imogen Wilding
IPC分类号： C12N1500
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/3156 , G01N33/5008 , G01N33/502 , G01N33/573 , G01N33/6872
摘要： The invention provides nrdE polypeptides and polynucleotides encoding nrdE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdE polypeptides to screen for antibacterial compounds.
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公开(公告)号：US06335424B1
公开(公告)日：2002-01-01
申请号：US08979616
申请日：1997-11-25
申请人： Michael Terence Black , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , David Justin Charles Knowles , Anna Lisa Kosmatka , Jeffrey Mooney , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
发明人： Michael Terence Black , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , David Justin Charles Knowles , Anna Lisa Kosmatka , Jeffrey Mooney , Richard Oakley Nicholas , Leslie Marie Palmer , Lisa Kathleen Shilling , Robert King Stodola , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
IPC分类号： A61K3902
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C12N9/1205 , C12N9/78 , C12N9/80 , C12N9/90 , C12N15/52 , C12Y207/01002
摘要： The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribG多肽筛选抗菌化合物的方法。
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公开(公告)号：US06242249B1
公开(公告)日：2001-06-05
申请号：US09414664
申请日：1999-10-07
申请人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
发明人： Martin Karl Russel Burnham , Andrew Fosberry , John Edward Hodgson , Deborah Dee Jaworski , Elizabeth J Lawlor , Martin Rosenberg , Christopher Michael Traini , Min Wang , Judith Ward , Richard Warren
IPC分类号： C07H2104
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/51 , C12N9/90
摘要： The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了tig多肽和编码tig多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用tig多肽筛选抗菌化合物的方法。
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公开(公告)号：US06171598B2
公开(公告)日：2001-01-09
申请号：US09225967
申请日：1999-01-06
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： A61K3850
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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