公开(公告)号：US08608672B2

公开(公告)日：2013-12-17

申请号：US11562749

申请日：2006-11-22

申请人： Kobi Vortman ,  Yoav Medan ,  Avner Ezion

发明人： Kobi Vortman ,  Yoav Medan ,  Avner Ezion

IPC分类号： A61H1/00

CPC分类号： G01S15/8927 ,  A61B8/4494 ,  G01S7/52019 ,  G01S15/8925 ,  G10K11/346

摘要： A focused ultrasound system comprises a transducer having a multiplicity of transducer elements, drive circuitry that generates and outputs a plurality of drive signals, each offset by a respective phase difference, and a controller for selectively coupling the drive signals to respective transducer elements, the controller including a plurality of first tier switching modules and second tier switching modules. Each first tier module receives as an input the plurality of drive signals and outputs one of the drive signals in response to a drive signal selection signal. Each second tier module is coupled to a respective grouping of transducer elements and selectively couples a respective selected drive signal output from a first tier switching module to one or more of the transducer elements in response to a transducer element selection signal.

摘要翻译： 聚焦超声系统包括具有多个换能器元件的换能器，产生并输出多个驱动信号的驱动电路，每个驱动信号偏移各自的相位差;以及控制器，用于选择性地将驱动信号耦合到相应的换能器元件，控制器 包括多个第一层交换模块和第二层交换模块。 每个第一层模块响应于驱动信号选择信号接收多个驱动信号作为输入并输出其中一个驱动信号。 每个第二层模块耦合到相应的换能器组分组，并且响应于换能器元件选择信号，选择性地将从第一层切换模块输出的相应选择的驱动信号耦合到一个或多个换能器元件。

公开(公告)号：US07128711B2

公开(公告)日：2006-10-31

申请号：US10106562

申请日：2002-03-25

申请人： Yoav Medan ,  Avner Ezion

发明人： Yoav Medan ,  Avner Ezion

IPC分类号： A61B8/12

CPC分类号： A61B17/2255 ,  A61B8/4209 ,  A61B17/2256 ,  A61B34/20 ,  A61B2034/2063 ,  A61B2090/374

摘要： Systems and methods are provided for positioning a therapy device, such as an ultrasound transducer, using a tilt sensor carried by the transducer and a positioner coupled to the transducer. The positioner provides roll and pitch control as well as translating the transducer in lateral and longitudinal directions. A processor receives signals from the tilt sensor corresponding to the actual rotational orientation of the transducer and controls the positioner to adjust the orientation of the therapy device until a desired position is achieved.

公开(公告)号：US20070167781A1

公开(公告)日：2007-07-19

申请号：US11562749

申请日：2006-11-22

申请人： Kobi Vortman ,  Yoav Medan ,  Avner Ezion

发明人： Kobi Vortman ,  Yoav Medan ,  Avner Ezion

IPC分类号： A61B8/00

CPC分类号： G01S15/8927 ,  A61B8/4494 ,  G01S7/52019 ,  G01S15/8925 ,  G10K11/346

摘要： A focused ultrasound system comprises a transducer having a multiplicity of transducer elements, drive circuitry that generates and outputs a plurality of drive signals, each offset by a respective phase difference, and a controller for selectively coupling the drive signals to respective transducer elements, the controller including a plurality of first tier switching modules and second tier switching modules. Each first tier module receives as an input the plurality of drive signals and outputs one of the drive signals in response to a drive signal selection signal. Each second tier module is coupled to a respective grouping of transducer elements and selectively couples a respective selected drive signal output from a first tier switching module to one or more of the transducer elements in response to a transducer element selection signal.

摘要翻译： 聚焦超声系统包括具有多个换能器元件的换能器，产生并输出多个驱动信号的驱动电路，每个驱动信号偏移各自的相位差;以及控制器，用于选择性地将驱动信号耦合到相应的换能器元件，控制器 包括多个第一层交换模块和第二层交换模块。 每个第一层模块响应于驱动信号选择信号接收多个驱动信号作为输入并输出其中一个驱动信号。 每个第二层模块耦合到相应的换能器组分组，并且响应于换能器元件选择信号，选择性地将从第一层切换模块输出的相应选择的驱动信号耦合到一个或多个换能器元件。

公开(公告)号：US08002706B2

公开(公告)日：2011-08-23

申请号：US12559939

申请日：2009-09-15

申请人： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

发明人： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

IPC分类号： A61B8/00

CPC分类号： G10K11/346 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095

摘要： A focused ultrasound system includes a transducer array, a controller for providing drive signals to the transducer array, and a switch. The transducer array includes a plurality of “n” transducer elements, and the controller includes a plurality of “m” output channels providing sets of drive signals having respective phase shift values, “m” being less than “n.” The switch is coupled to the output channels of the controller and to the transducer elements, and is configured for connecting the output channels to respective transducer elements. The controller may assign the transducer elements to respective output channels based upon a size and/or shape of a desired focal zone within the target region, to steer or otherwise move a location of the focal zone, and/or to compensate for tissue aberrations caused by tissue between the transducer array and the focal zone, geometric tolerances and/or impedance variations of the transducer elements.

摘要翻译： 聚焦超声系统包括换能器阵列，用于向换能器阵列提供驱动信号的控制器和开关。 换能器阵列包括多个“n”个换能器元件，并且控制器包括多个“m”个输出通道，提供具有各自的相移值的驱动信号组，“m”小于“n”。开关被耦合 到控制器和换能器元件的输出通道，并且被配置为将输出通道连接到相应的换能器元件。 控制器可以基于目标区域内的期望焦点区域的尺寸和/或形状来将换能器元件分配到相应的输出通道，以引导或以其他方式移动聚焦区域的位置，和/或补偿由此产生的组织像差 通过换能器阵列和焦点区域之间的组织，换能器元件的几何公差和/或阻抗变化。

公开(公告)号：US20100056962A1

公开(公告)日：2010-03-04

申请号：US12559939

申请日：2009-09-15

申请人： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

发明人： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

IPC分类号： A61N7/00 ,  A61B18/04 ,  G10K9/125 ,  H01L41/09

CPC分类号： G10K11/346 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095

摘要： A focused ultrasound system includes a transducer array, a controller for providing drive signals to the transducer array, and a switch. The transducer array includes a plurality of “n” transducer elements, and the controller includes a plurality of “m” output channels providing sets of drive signals having respective phase shift values, “m” being less than “n.” The switch is coupled to the output channels of the controller and to the transducer elements, and is configured for connecting the output channels to respective transducer elements. The controller may assign the transducer elements to respective output channels based upon a size and/or shape of a desired focal zone within the target region, to steer or otherwise move a location of the focal zone, and/or to compensate for tissue aberrations caused by tissue between the transducer array and the focal zone, geometric tolerances and/or impedance variations of the transducer elements.

摘要翻译： 聚焦超声系统包括换能器阵列，用于向换能器阵列提供驱动信号的控制器和开关。 换能器阵列包括多个“n”个换能器元件，并且控制器包括多个“m”个输出通道，提供具有各自的相移值的驱动信号组，“m”小于“n”。开关被耦合 到控制器和换能器元件的输出通道，并且被配置为将输出通道连接到相应的换能器元件。 控制器可以基于目标区域内的期望焦点区域的尺寸和/或形状来将换能器元件分配到相应的输出通道，以引导或以其他方式移动聚焦区域的位置，和/或补偿由此产生的组织像差 通过换能器阵列和焦点区域之间的组织，换能器元件的几何公差和/或阻抗变化。

公开(公告)号：US07611462B2

公开(公告)日：2009-11-03

申请号：US10443549

申请日：2003-05-22

申请人： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

发明人： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

IPC分类号： A61B8/00

CPC分类号： G10K11/346 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095

摘要： A focused ultrasound system includes a transducer array, a controller for providing drive signals to the transducer array, and a switch. The transducer array includes a plurality of “n” transducer elements, and the controller includes a plurality of “m” output channels providing sets of drive signals having respective phase shift values, “m” being less than “n.” The switch is coupled to the output channels of the controller and to the transducer elements, and is configured for connecting the output channels to respective transducer elements. The controller may assign the transducer elements to respective output channels based upon a size and/or shape of a desired focal zone within the target region, to steer or otherwise move a location of the focal zone, and/or to compensate for tissue aberrations caused by tissue between the transducer array and the focal zone, geometric tolerances and/or impedance variations of the transducer elements.

摘要翻译： 聚焦超声系统包括换能器阵列，用于向换能器阵列提供驱动信号的控制器和开关。 换能器阵列包括多个“n”个换能器元件，并且控制器包括多个“m”个输出通道，其提供具有各自相移值的驱动信号组，“m”小于“n”。 开关耦合到控制器和换能器元件的输出通道，并且被配置为将输出通道连接到相应的换能器元件。 控制器可以基于目标区域内的期望焦点区域的尺寸和/或形状来将换能器元件分配到相应的输出通道，以引导或以其他方式移动聚焦区域的位置，和/或补偿由此产生的组织像差 通过换能器阵列和焦点区域之间的组织，换能器元件的几何公差和/或阻抗变化。

公开(公告)号：US07175596B2

公开(公告)日：2007-02-13

申请号：US10020737

申请日：2001-10-29

申请人： Shuki Vitek ,  Avner Ezion

发明人： Shuki Vitek ,  Avner Ezion

IPC分类号： A61B8/00

CPC分类号： G01S15/8909 ,  A61B2018/00642 ,  A61B2090/374 ,  A61N7/02 ,  G01S7/52025 ,  G01S7/52058

摘要： A method for sensing a disturbance in a transmission path of a converging ultrasound energy beam transmitted by a transducer in a focussed ultrasound system comprises transmitting a burst of ultrasound energy from the transducer, detecting whether a reflected portion of the ultrasound energy burst is received at the transducer within a certain time period following transmission of the burst, and, if so, analyzing the received reflected portion to determine a characteristic of the disturbance.

摘要翻译： 用于感测在聚焦超声系统中由换能器发射的会聚超声能量束的传播路径中的干扰的方法包括从所述换能器传输超声能量脉冲串，检测所述超声波能量突发的反射部分是否在 在传输脉冲串之后的特定时间段内的传感器，如果是，则分析所接收的反射部分以确定干扰的特性。

公开(公告)号：US06735461B2

公开(公告)日：2004-05-11

申请号：US09884206

申请日：2001-06-19

申请人： Shuki Vitek ,  Avner Ezion ,  David Freundlich

发明人： Shuki Vitek ,  Avner Ezion ,  David Freundlich

IPC分类号： A61B5055

CPC分类号： G01R33/28 ,  G01R33/4804

摘要： Systems and methods for performing a focused ultrasound procedure monitored using magnetic resonance imaging (MRI) is provided. An MRI system uses a timing sequence for transmitting radio frequency (RF) signals and detecting magnetic resonance (MR) response signals from a patient's body in response to the RF pulse sequences. A piezoelectric transducer is driven with drive signals such that the transducer emits acoustic energy towards a target tissue region within the patient's body. Parameters of the drive signals are changed at times during the timing sequence that minimize interference with the MRI system detecting MR response signals, e.g., during transmission of RF signals by the MRI system.

摘要翻译： 提供了使用磁共振成像（MRI）监测的用于执行聚焦超声程序的系统和方法。 MRI系统使用用于响应于RF脉冲序列从患者身体发射射频（RF）信号和检测磁共振（MR）响应信号的定时序列。 用驱动信号驱动压电换能器，使得换能器向患者体内的目标组织区域发射声能。 驱动信号的参数在定时序列期间的时间被改变，以使MRI检测MR响应信号的干扰最小化，例如在MRI系统的RF信号传输期间。

公开(公告)号：US06506154B1

公开(公告)日：2003-01-14

申请号：US09724611

申请日：2000-11-28

申请人： Avner Ezion ,  Kolisher Izzydor ,  Shuki Vitek

发明人： Avner Ezion ,  Kolisher Izzydor ,  Shuki Vitek

IPC分类号： A61B800

CPC分类号： G10K11/341

摘要： Systems and methods for controlling the phase and amplitude of individual drive sinus waves of a phased-array focused ultrasound transducer employ digitally controlled components to scale the amplitude of three or more bases sinuses into component sinus vectors. The component sinus vectors are linearly combined to generate the respective sinus of a selected phase and amplitude. The use of digitally controlled controlled components allows for digitally controlled switching between various distances, shapes and orientations (“characteristics”) of the focal zone of the transducer. The respective input parameters for any number of possible focal zone characteristics may be stored in a comprehensive table or memory for readily switching between focal zone characteristics in &mgr; seconds. Changes in the output frequency are accomplished without impacting on the specific focal zone characteristics of the transducer output. Sequential changes in the transducer focal zone characteristics are implemented in the form of sequential sets of digital control signals transmitted from the central controller to respective control channels for generating the individual sinus waves. The digital control signals may be changed in accordance with a time-domain function as part of a single thermal dose.

摘要翻译： 用于控制相控阵聚焦超声换能器的单个驱动窦波的相位和振幅的系统和方法使用数字控制的分量来将三个或更多个基极窦的幅度缩放成分量窦性矢量。 组分窦性矢量被线性组合以产生所选相位和幅度的相应窦。 使用数字控制的受控组件允许在换能器的焦点区域的各种距离，形状和取向（“特性”）之间进行数字控制的切换。 任何数量的可能焦点区域特征的各个输入参数可以存储在综合表或存储器中，以便在mu秒内容易地切换焦点区域特性。 在不影响传感器输出的特定焦点区域特性的情况下实现输出频率的变化。 换能器焦区特性的顺序变化以从中央控制器发送到用于产生单个窦波的相应控制通道的顺序数字控制信号集的形式实现。 可以根据作为单一热剂量的一部分的时域功能来改变数字控制信号。