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公开(公告)号：US5550292A
公开(公告)日：1996-08-27
申请号：US428114
申请日：1995-04-29
申请人： Yohji Sakurai , Nobuyuki Kurahashi , Tsuyoshi Hirose , Takashi Miwa , Atsushi Mori , Takao Nishi
发明人： Yohji Sakurai , Nobuyuki Kurahashi , Tsuyoshi Hirose , Takashi Miwa , Atsushi Mori , Takao Nishi
IPC分类号： C07C217/58
CPC分类号： C07C217/58 , C07C2101/02 , C07C2101/04 , C07C2101/14
摘要： A benzylamine derivative or salt thereof having antidepressant and antianxiety activities having the general formula: ##STR1## wherein R.sup.1 is a lower alkyl group;R.sup.2 is a cycloalkyl group; andR.sup.3 is a halogen atom;or salt thereof.
摘要翻译： PCT No.PCT / JP94 / 01332 Sec。 371日期：1995年4月28日 102（e）1995年4月28日PCT PCT 1994年8月11日PCT公布。 公开号WO95 / 06630 日期：1995年3月9日具有抗抑郁和抗焦虑活性的苄胺衍生物或其盐具有以下通式：其中R 1为低级烷基; R2是环烷基; R3为卤素原子; 或其盐。
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2.发明授权Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders 有权卡波他汀衍生物和5-羟色胺再摄取抑制剂治疗情绪障碍公开(公告)号：US08759350B2
公开(公告)日：2014-06-24
申请号：US10540577
申请日：2003-12-25
申请人： Tetsuro Kikuchi , Taro Iwamoto , Tsuyoshi Hirose
发明人： Tetsuro Kikuchi , Taro Iwamoto , Tsuyoshi Hirose
IPC分类号： A61K31/496 , A61K31/501 , A61K31/34
CPC分类号： A61K31/137 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/4525 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The pharmaceutical composition of the present invention comprises (1) a carbostyril derivative and (2) a serotonin reuptake inhibitor in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof, which is a dopamine-serotonin system stabilizer. The serotonin reuptake inhibitor may be fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine, sertraline or escitalopram. The pharmaceutical composition of the present invention is useful for treating patients with mood disorders, particularly depression or major depressive disorder.
摘要翻译： 本发明的药物组合物包含（1）喹诺酮衍生物和（2）可药用载体中的5-羟色胺再摄取抑制剂。 喹诺酮类衍生物可以是阿立哌唑或其代谢物，其是多巴胺5-羟色胺系统稳定剂。 5-羟色胺再摄取抑制剂可以是氟西汀，度洛西汀，文拉法辛，米那普仑，西酞普兰，氟伏沙明，帕罗西汀，舍曲林或依他普仑。 本发明的药物组合物可用于治疗情绪障碍，特别是抑郁症或重度抑郁症的患者。
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公开(公告)号：US08604041B2
公开(公告)日：2013-12-10
申请号：US13195954
申请日：2011-08-02
IPC分类号： A61K31/496
CPC分类号： A61K31/496 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
摘要翻译： 本发明涉及一种治疗患有与5-HT 1A受体亚型相关的中枢神经系统紊乱的患者的方法，其包含由式（1）表示的喹诺酮衍生物或其盐作为活性成分：其中， 喹诺酮骨架中3-和4-位之间的碳 - 碳键是单键或双键。
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公开(公告)号：US08501742B2
公开(公告)日：2013-08-06
申请号：US13195954
申请日：2011-08-02
IPC分类号： A61K31/496
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
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公开(公告)号：US20120095018A1
公开(公告)日：2012-04-19
申请号：US13327618
申请日：2011-12-15
IPC分类号： A61K31/496 , A61P25/16 , A61P25/28
CPC分类号： A61K31/496 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1) wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
摘要翻译： 本发明涉及一种治疗患有与5-HT 1A受体亚型相关的中枢神经系统病症的患者的方法，其包含由式（1）表示的喹诺酮衍生物或其盐作为活性成分，其中碳 喹诺酮骨架中3-和4-位之间的碳键是单键或双键。
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公开(公告)号：US20090012098A1
公开(公告)日：2009-01-08
申请号：US12202201
申请日：2008-08-29
IPC分类号： A61K31/496 , A61P25/28
CPC分类号： A61K31/496 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1) wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
摘要翻译： 本发明涉及一种治疗患有与5-HT 1A受体亚型相关的中枢神经系统病症的患者的方法，其包含由式（1）表示的喹诺酮衍生物或其盐作为活性成分，其中碳 喹诺酮骨架中3-和4-位之间的碳键是单键或双键。
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公开(公告)号：US20050223223A1
公开(公告)日：2005-10-06
申请号：US11094517
申请日：2005-03-31
申请人： Tsuyoshi Hirose
发明人： Tsuyoshi Hirose
CPC分类号： G06F21/10 , G06F21/6209
摘要： In order to solve concerns about processes performed on a display screen for an authentication program which limits access to each file, the authentication program has an authentication process to request authentication of each file at the time of using the files. The authentication process controls a computer to execute operations of analyzing the authentication character-string input for the file name, determining whether the result of analysis is right or wrong, and opening and closing the file to enable use of the file when the result of analysis is right and to disable use of the file when the analysis result is wrong.
摘要翻译： 为了解决对用于限制对每个文件的访问的认证程序的显示屏幕上执行的处理的关注，认证程序具有在使用文件时请求对每个文件的认证的认证处理。 认证过程控制计算机执行分析文件名的认证字符串输入，确定分析结果是正确还是错误的操作，以及打开和关闭文件以在分析结果时使用该文件 是正确的，并且当分析结果错误时禁用文件的使用。
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8.发明授权Read and/or write integrated circuit having an operation timing adjusting circuit and constant current elements 失效具有操作定时调节电路和恒流元件的读和/或写集成电路
公开(公告)号：US5434717A
公开(公告)日：1995-07-18
申请号：US214846
申请日：1994-03-18
申请人： Masaki Yoshinaga , Yuji Nagaya , Tsuyoshi Hirose , Noriaki Hatanaka , Tomoaki Hirai , Tatsuo Mochizuki
发明人： Masaki Yoshinaga , Yuji Nagaya , Tsuyoshi Hirose , Noriaki Hatanaka , Tomoaki Hirai , Tatsuo Mochizuki
IPC分类号： G11B5/00 , G11B5/012 , G11B5/02 , G11B5/40 , G11B5/455 , G11B5/48 , G11B19/02 , G11B19/04 , G11B20/18 , H03F3/45 , H03F3/72 , G11B5/09 , G11B15/14
CPC分类号： G11B5/012 , G11B19/02 , G11B19/04 , G11B20/1879 , G11B5/02 , G11B5/455 , H03F3/45085 , H03F3/72 , G11B2005/001 , G11B5/40 , G11B5/4886 , H03F2203/45392 , H03F2203/45496 , H03F2203/45506 , H03F2203/45702 , H03F2203/45722 , H03F2203/45728
摘要： A timing adjusting circuit is provided to define the operating order of a differential amplifier circuit for amplifying read-out signals and an output circuit in order to minimize changes in output DC level. A damping resistor is disposed between two magnetic head terminals and a clamp circuit in a magnetic head driving circuit. To attend to a composite head configuration, short-circuiting with a power supply and a current flowing into the magnetic head during a non-write operation are detected as abnormalities. In addition, short-circuiting and open-circuiting of the magnetic head are also detected as abnormalities. Also, a read circuit is added to a write magnetic head, in order to output read-out signals in a read mode, so that the read-out signals are utilized for detecting errors in read-out signals from an exclusively designed read head or for detecting and correcting such errors.
摘要翻译： 提供定时调整电路以定义用于放大读出信号的差分放大器电路的工作顺序和输出电路，以便最小化输出DC电平的变化。 阻尼电阻器设置在磁头驱动电路中的两个磁头端子和钳位电路之间。 为了参与复合头配置，在非写入操作期间，用电源短路和流入磁头的电流被检测为异常。 此外，磁头的短路和开路也被检测为异常。 此外，读写电路被添加到写磁头，以便以读模式输出读出信号，使得读出信号用于检测来自专门设计的读头的读出信号中的错误，或 用于检测和纠正这种错误。
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公开(公告)号：US08623874B2
公开(公告)日：2014-01-07
申请号：US12202201
申请日：2008-08-29
IPC分类号： A61K31/496
CPC分类号： A61K31/496 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1) wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
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公开(公告)号：US20120088777A1
公开(公告)日：2012-04-12
申请号：US13327607
申请日：2011-12-15
IPC分类号： A61K31/496 , A61P43/00
CPC分类号： A61K31/496 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT1A receptor subtype, comprising as an active ingredient a carbostyril derivative or a salt thereof represented by the formula (1): wherein the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or a double bond.
摘要翻译： 本发明涉及一种治疗患有与5-HT 1A受体亚型相关的中枢神经系统紊乱的患者的方法，其包含由式（1）表示的喹诺酮衍生物或其盐作为活性成分：其中， 喹诺酮骨架中3-和4-位之间的碳 - 碳键是单键或双键。
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