公开(公告)号：US20050037470A1

公开(公告)日：2005-02-17

申请号：US10614922

申请日：2003-07-08

申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

IPC分类号： C12P19/18 ,  C07H1/00 ,  C07H19/167 ,  C07H19/173 ,  C12N1/20 ,  C12P19/40 ,  C12R1/07 ,  C07H19/00 ,  C07H19/22 ,  C12P19/30

CPC分类号： C12P19/40

摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

摘要翻译： 通过使乙二醛 - 鸟嘌呤与嘌呤核苷磷酸化酶存在下的核糖-1-磷酸和2-脱氧核糖-1-磷酸的任一种反应，或通过使乙二醛 - 鸟嘌呤与选定的任何一种反应来制备乙二醛 - 鸟苷类化合物 在嘌呤核苷磷酸化酶和嘧啶核苷磷酸化酶存在下，由尿苷，2'-脱氧尿苷和胸苷以及磷酸根离子组成的组。 然后将乙二醛 - 鸟苷类化合物用碱分解，由此制备由鸟苷和2'-脱氧鸟苷组成的鸟苷类化合物。

公开(公告)号：US07141396B2

公开(公告)日：2006-11-28

申请号：US10614922

申请日：2003-07-08

申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

IPC分类号： C12P19/40

CPC分类号： C12P19/40

摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

公开(公告)号：US07148042B2

公开(公告)日：2006-12-12

申请号：US10615265

申请日：2003-07-08

申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

IPC分类号： C12P19/40

CPC分类号： C12P19/40

摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

摘要翻译： 通过使乙二醛 - 鸟嘌呤与嘌呤核苷磷酸化酶存在下的核糖-1-磷酸和2-脱氧核糖-1-磷酸的任一种反应，或通过使乙二醛 - 鸟嘌呤与选定的任何一种反应来制备乙二醛 - 鸟苷类化合物 在嘌呤核苷磷酸化酶和嘧啶核苷磷酸化酶存在下，由尿苷，2'-脱氧尿苷和胸苷以及磷酸根离子组成的组。 然后将乙二醛 - 鸟苷类化合物用碱分解，由此制备由鸟苷和2'-脱氧鸟苷组成的鸟苷类化合物。

公开(公告)号：US07141397B2

公开(公告)日：2006-11-28

申请号：US10615264

申请日：2003-07-08

申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

IPC分类号： C12P19/40

CPC分类号： C12P19/40

摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

公开(公告)号：US06620596B2

公开(公告)日：2003-09-16

申请号：US09808448

申请日：2001-03-14

申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

IPC分类号： C12P1940

CPC分类号： C12P19/40

摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

摘要翻译： 通过使乙二醛 - 鸟嘌呤与嘌呤核苷磷酸化酶存在下的核糖-1-磷酸和2-脱氧核糖-1-磷酸的任一种反应，或通过使乙二醛 - 鸟嘌呤与选定的任何一种反应来制备乙二醛 - 鸟苷类化合物 在嘌呤核苷磷酸化酶和嘧啶核苷磷酸化酶存在下，由尿苷，2'-脱氧尿苷和胸苷以及磷酸根离子组成的组。 然后将乙二醛 - 鸟苷类化合物用碱分解，由此制备由鸟苷和2'-脱氧鸟苷组成的鸟苷类化合物。

公开(公告)号：US5948444A

公开(公告)日：1999-09-07

申请号：US933407

申请日：1997-09-19

申请人： Noboru Naito ,  Toyoki Sato

发明人： Noboru Naito ,  Toyoki Sato

IPC分类号： E04G23/02

CPC分类号： E04G23/0203

摘要： An injection plug device for injecting concrete repairing agent into a concrete structure and a connector to be connected to such an injection plug device are provided. The injection plug device has a small diameter, a simple structure, and low manufacturing cost to be appropriate to be used as a disposable device. The injection plug device (10) for injecting concrete repairing agent into a concrete structure includes a tip side injection pipe (11); an end side injection pipe (12) for housing an end portion of the tip side injection pipe (11) at the tip portion thereof, an attaching device (13) comprising an elastic member(13a) attached to the tip side injection pipe(11) to surround the outer surface thereof, and a compression device for compressing the elastic member(13a) in a direction parallel to an axis thereof to cause an expansion of the elastic member(13a) in its radial direction to make the elastic member attached to a inner wall of an injection hole; and a back flow preventing device (14) formed inside of the end side injection pipe for preventing back flow of injected concrete repairing agent before its solidification.

摘要翻译： 提供了一种用于将混凝土修复剂注入到混凝土结构中的注射塞装置和要连接到这种注射塞装置的连接器。 注射塞装置的直径小，结构简单，制造成本低，适合用作一次性装置。 用于将混凝土修复剂注入混凝土结构的注射塞装置（10）包括尖端侧注入管（11）; 一个端部侧注入管（12），用于将尖端侧注射管（11）的端部容纳在其末端部分;一个附接装置（13），包括一个安装在尖端侧注射管（11）上的弹性件 ）包围其外表面，以及压缩装置，用于在平行于其轴线的方向上压缩弹性构件（13a），以使弹性构件（13a）在其径向方向上膨胀，以使弹性构件附接到 注入孔的内壁; 以及形成在所述端侧喷射管的内侧的防回流装置（14），用于防止注入的混凝土修复剂在凝固之前的回流。