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    Method of preparing a guanosine-group compound and an intermediate thereof
    1.
    发明申请
    Method of preparing a guanosine-group compound and an intermediate thereof 有权
    制备鸟苷类化合物及其中间体的方法

    公开(公告)号：US20050037470A1

    公开(公告)日：2005-02-17

    申请号：US10614922

    申请日：2003-07-08

    申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

    发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

    IPC分类号： C12P19/18 ,  C07H1/00 ,  C07H19/167 ,  C07H19/173 ,  C12N1/20 ,  C12P19/40 ,  C12R1/07 ,  C07H19/00 ,  C07H19/22 ,  C12P19/30

    CPC分类号： C12P19/40

    摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

    摘要翻译： 通过使乙二醛 - 鸟嘌呤与嘌呤核苷磷酸化酶存在下的核糖-1-磷酸和2-脱氧核糖-1-磷酸的任一种反应，或通过使乙二醛 - 鸟嘌呤与选定的任何一种反应来制备乙二醛 - 鸟苷类化合物 在嘌呤核苷磷酸化酶和嘧啶核苷磷酸化酶存在下，由尿苷，2'-脱氧尿苷和胸苷以及磷酸根离子组成的组。 然后将乙二醛 - 鸟苷类化合物用碱分解，由此制备由鸟苷和2'-脱氧鸟苷组成的鸟苷类化合物。

    Method of preparing a guanosine-group compound and an intermediate thereof
    2.
    发明授权
    Method of preparing a guanosine-group compound and an intermediate thereof 有权
    制备鸟苷类化合物及其中间体的方法

    公开(公告)号：US07148042B2

    公开(公告)日：2006-12-12

    申请号：US10615265

    申请日：2003-07-08

    申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

    发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

    IPC分类号： C12P19/40

    CPC分类号： C12P19/40

    摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

    摘要翻译： 通过使乙二醛 - 鸟嘌呤与嘌呤核苷磷酸化酶存在下的核糖-1-磷酸和2-脱氧核糖-1-磷酸的任一种反应，或通过使乙二醛 - 鸟嘌呤与选定的任何一种反应来制备乙二醛 - 鸟苷类化合物 在嘌呤核苷磷酸化酶和嘧啶核苷磷酸化酶存在下，由尿苷，2'-脱氧尿苷和胸苷以及磷酸根离子组成的组。 然后将乙二醛 - 鸟苷类化合物用碱分解，由此制备由鸟苷和2'-脱氧鸟苷组成的鸟苷类化合物。

    Method of preparing a guanosine-group compound
    4.
    发明授权
    Method of preparing a guanosine-group compound 有权
    鸟苷类化合物的制备方法

    公开(公告)号：US06620596B2

    公开(公告)日：2003-09-16

    申请号：US09808448

    申请日：2001-03-14

    申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

    发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Yoshinori Hayashi ,  Toyoki Sato

    IPC分类号： C12P1940

    CPC分类号： C12P19/40

    摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

    摘要翻译： 通过使乙二醛 - 鸟嘌呤与嘌呤核苷磷酸化酶存在下的核糖-1-磷酸和2-脱氧核糖-1-磷酸的任一种反应，或通过使乙二醛 - 鸟嘌呤与选定的任何一种反应来制备乙二醛 - 鸟苷类化合物 在嘌呤核苷磷酸化酶和嘧啶核苷磷酸化酶存在下，由尿苷，2'-脱氧尿苷和胸苷以及磷酸根离子组成的组。 然后将乙二醛 - 鸟苷类化合物用碱分解，由此制备由鸟苷和2'-脱氧鸟苷组成的鸟苷类化合物。

    Method of preparing purine nucleoside compound
    6.
    发明授权
    Method of preparing purine nucleoside compound 失效
    制备嘌呤核苷化合物的方法

    公开(公告)号：US6017736A

    公开(公告)日：2000-01-25

    申请号：US120458

    申请日：1998-07-23

    申请人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Shinjhi Yoshinaka ,  Yonosuke Sunaga ,  Ayumi Hasegawa

    发明人： Yoichi Mikami ,  Seiichiro Matsumoto ,  Shinjhi Yoshinaka ,  Yonosuke Sunaga ,  Ayumi Hasegawa

    IPC分类号： C12N1/20 ,  C12P19/40 ,  C12R1/01 ,  C12R1/06 ,  C12R1/11 ,  C12R1/38 ,  C07H19/16 ,  C12P19/00 ,  C12P19/38

    CPC分类号： C12P19/40

    摘要： The present invention provides a method of preparing stably and at a high yield a purine nucleoside compound by utilizing an exchange reaction of a nucleic acid base which is carried out in the presence of an enzyme, and also provides a microorganism capable of producing uracil thymine dehydrogenase or dihydrouracil dehydrogenase. In preparing the purine nucleoside compound, a pyrimidine nucleoside compound and a purine base are subjected to a base exchange reaction in an aqueous solution containing phosphate ions in the presence of pyrimidine nucleoside phosphorylase and purine nucleoside phosphorylase. The pyrimidine base formed by the base exchange reaction is converted by a microorganism or an enzyme derived from the microorganism into a compound incapable of acting as substrates of pyrimidine nucleoside phosphorylase and purine nucleoside phosphorylase so as to obtain a desired product of purine nucleoside compound.

    摘要翻译： 本发明提供了通过利用在酶的存在下进行的核酸碱基的交换反应来稳定且高产率地制备嘌呤核苷化合物的方法，并且还提供能够产生尿嘧啶胸腺嘧啶脱氢酶的微生物 或二氢尿嘧啶脱氢酶。 在制备嘌呤核苷化合物中，嘧啶核苷化合物和嘌呤碱在嘧啶核苷磷酸化酶和嘌呤核苷磷酸化酶存在下，在含磷酸根离子的水溶液中进行碱交换反应。 通过碱交换反应形成的嘧啶碱被微生物或来源于微生物的酶转化为不能作为嘧啶核苷磷酸化酶和嘌呤核苷磷酸化酶底物的化合物，以获得所需的嘌呤核苷化合物产物。

    Process for Preparing 2-Hydroxy-Substituted Pyridines
    9.
    发明申请
    Process for Preparing 2-Hydroxy-Substituted Pyridines 有权
    2-羟基取代的吡啶的制备方法

    公开(公告)号：US20080286843A1

    公开(公告)日：2008-11-20

    申请号：US11575455

    申请日：2005-09-16

    申请人： Mie Sasaki ,  Seiichiro Matsumoto

    发明人： Mie Sasaki ,  Seiichiro Matsumoto

    IPC分类号： C12P17/12 ,  C12N1/20 ,  C07D211/72

    CPC分类号： C12R1/01 ,  C07D213/64 ,  C07D213/78 ,  C07D213/803 ,  C12N1/20 ,  C12P17/12

    摘要： A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided.According to the process, a function of a microorganism or a product obtained therefrom is exerted on a 4-substituted pyridine of the general formula (1): wherein R is a methyl group, a carboxyl group, a carbamoyl group, a hydroxyiminomethyl group or a cyano group, to obtain the corresponding 2-hydroxy-4-substituted pyridine compound. The novel microorganisms are the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) and the novel compound is a 2-hydroxy-4-pyridinaldoxime.

    摘要翻译： 提供了使用微生物学方法制备2-羟基-4-取代的吡啶化合物的方法，新的微生物和新的化合物。 根据该方法，由通式（1）的4​​-取代吡啶施加微生物或其产物的功能：其中R是甲基，羧基，氨基甲酰基，羟基亚氨基甲基或 氰基，得到相应的2-羟基-4-取代的吡啶化合物。 新型微生物是Delftia物种YGK-A649（FERM BP-10389），Delftia物种YGK-C217（FERM BP-10388）或Acidovorax物种YGK-A854（FERM BP-10387），新化合物是2-羟基 -4-吡啶酮肟。