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公开(公告)号：US07309708B2
公开(公告)日：2007-12-18
申请号：US10992566
申请日：2004-11-18
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D409/14 , A61K38/212 , A61K45/06 , C04B35/632 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07K5/0808
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有以下通式的丙型肝炎病毒抑制剂：其中R 1，R 2，R 3，R'，B，Y和X 在说明书中描述。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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公开(公告)号：US07741281B2
公开(公告)日：2010-06-22
申请号：US11591253
申请日：2006-11-01
申请人： Stanley D'Andrea , Zhizhen Barbara Zheng , Jeffrey Allen Campbell , Fiona McPhee , Andrew Charles Good , Paul Michael Scola
发明人： Stanley D'Andrea , Zhizhen Barbara Zheng , Jeffrey Allen Campbell , Fiona McPhee , Andrew Charles Good , Paul Michael Scola
IPC分类号： A61K38/00
CPC分类号： A61K38/204 , A61K38/2013 , A61K38/208 , A61K38/212 , C07K5/06139 , C07K5/0804 , A61K2300/00
摘要： Macrocyclic peptides are disclosed having the general formula: wherein R′, R3, R3′, R4, R6, X, Q, and W are described. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有以下通式的大环肽：其中描述了R'，R 3，R 3'，R 4，R 6，X，Q和W。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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公开(公告)号：US06995174B2
公开(公告)日：2006-02-07
申请号：US10441657
申请日：2003-05-20
申请人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
发明人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
IPC分类号： C07D215/38 , C07D401/04 , C07D207/46 , A61K31/47 , A61K31/40
CPC分类号： A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有一般形式的丙型肝炎病毒抑制剂
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公开(公告)号：US20120330019A1
公开(公告)日：2012-12-27
申请号：US13597381
申请日：2012-08-29
申请人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
发明人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
IPC分类号： C07K5/062 , C07C311/51 , C07D217/24
CPC分类号： A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有以下通式的丙型肝炎病毒抑制剂：其中R1，R2，R3，R'，B，Y和X在说明书中描述。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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公开(公告)号：US07449479B2
公开(公告)日：2008-11-11
申请号：US11295914
申请日：2005-12-07
申请人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
发明人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Piyasena Hewawasam , Andrew Charles Good , Yan Chen , Jeffrey Allen Campbell
IPC分类号： A61K31/47 , C07D215/08
CPC分类号： A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有以下通式的丙型肝炎病毒抑制剂：其中R 1，R 2，R 3，R'，B，Y和X 在说明书中描述。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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公开(公告)号：US07173004B2
公开(公告)日：2007-02-06
申请号：US10825693
申请日：2004-04-16
申请人： Fiona McPhee , Jeffrey Allen Campbell , Stanley D'Andrea , Zhizhen Barbara Zheng , Andrew Charles Good , David J. Carini , Barry L. Johnson , Paul Michael Scola , Kenneth M. Boy
发明人： Fiona McPhee , Jeffrey Allen Campbell , Stanley D'Andrea , Zhizhen Barbara Zheng , Andrew Charles Good , David J. Carini , Barry L. Johnson , Paul Michael Scola , Kenneth M. Boy
IPC分类号： A61K38/00
CPC分类号： C07K5/0804 , A61K38/00 , C12P7/62 , C12P13/04 , C12P41/005
摘要： Macrocyclic isoquinoline peptides are disclosed having the general formula:A compound of formula I: wherein R1 to R9, Q and W are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有以下通式的大环异喹啉肽：式I化合物：其中R 1至R 9，Q和W在说明书中描述。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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公开(公告)号：US07041698B2
公开(公告)日：2006-05-09
申请号：US10441827
申请日：2003-05-20
申请人： Amy Ripka , Jeffrey Allen Campbell , Andrew Charles Good , Paul Michael Scola , Ny Sin , Brian Venables
发明人： Amy Ripka , Jeffrey Allen Campbell , Andrew Charles Good , Paul Michael Scola , Ny Sin , Brian Venables
IPC分类号： A61K31/4015 , C07D207/04
CPC分类号： A61K38/06 , A61K31/40 , C07D207/16 , C07K5/06165 , C07K5/0823
摘要： The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.
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公开(公告)号：US07592336B2
公开(公告)日：2009-09-22
申请号：US11430611
申请日：2006-05-09
申请人： Ny Sin , Paul Michael Scola , Nicholas A. Meanwell , Xiangdong Alan Wang , Li-Qiang Sun , Jie Chen , Andrew Charles Good
发明人： Ny Sin , Paul Michael Scola , Nicholas A. Meanwell , Xiangdong Alan Wang , Li-Qiang Sun , Jie Chen , Andrew Charles Good
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4025 , A61K31/40 , C07D413/10 , C07D401/10 , C07D207/04
CPC分类号： C07K5/0808
摘要： Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有通式的丙型肝炎病毒抑制剂。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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公开(公告)号：US07323447B2
公开(公告)日：2008-01-29
申请号：US11348721
申请日：2006-02-06
IPC分类号： A61K38/00 , C07D215/00 , C07D207/00
CPC分类号： C07D401/12 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/212 , C07D401/14 , C07D403/12 , C07K5/06139 , A61K2300/00
摘要： The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which inhibit the function of the NS3 protease (also referred to herein as “serine protease”) encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS3 protease.
摘要翻译： 本公开一般涉及抗病毒化合物，更具体地涉及抑制由丙型肝炎病毒（HCV）编码的NS3蛋白酶（本文中也称为“丝氨酸蛋白酶”）的功能的化合物，包含这些化合物的组合物，和 抑制NS3蛋白酶功能的方法。
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公开(公告)号：US20080152619A1
公开(公告)日：2008-06-26
申请号：US11430611
申请日：2006-05-09
申请人： Ny Sin , Paul Michael Scola , Nicholas A. Meanwell , Xiangdong Alan Wang , Li-Qiang Sun , Jie Chen , Andrew Charles Good
发明人： Ny Sin , Paul Michael Scola , Nicholas A. Meanwell , Xiangdong Alan Wang , Li-Qiang Sun , Jie Chen , Andrew Charles Good
IPC分类号： A61K38/20 , C07D207/06 , A61K31/401 , A61P31/14 , A61K38/21
CPC分类号： C07K5/0808
摘要： Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译： 公开了具有通式的丙型肝炎病毒抑制剂。 还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。
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