专利检索 ap:("Yongxin Han" OR "Andre Giroux" OR "Erich Grimm" OR "Renee Aspiotis" OR "Sebastien Francoeur" OR "Robert Zamboni" OR "Petpiboon Prasit" OR "Christopher Bayly" OR "Dan McKay" OR "Cameron Black") AND inv:"Sebastien Francoeur" 第 1 页

1.

发明授权
Gamma-ketoacid dipeptides as inhibitors of caspase-3 失效
标题翻译：伽马酮酸二肽作为半胱天冬酶-3的抑制剂

公开(公告)号：US06225288B1

公开(公告)日：2001-05-01

申请号：US09526840

申请日：2000-03-16

申请人： Yongxin Han , Andre Giroux , Erich Grimm , Renee Aspiotis , Sebastien Francoeur , Robert Zamboni , Petpiboon Prasit , Christopher Bayly , Dan McKay , Cameron Black

发明人： Yongxin Han , Andre Giroux , Erich Grimm , Renee Aspiotis , Sebastien Francoeur , Robert Zamboni , Petpiboon Prasit , Christopher Bayly , Dan McKay , Cameron Black

IPC分类号： C07K506

CPC分类号： C07D239/34 , C07C323/59

摘要： Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.

摘要翻译： 由式I表示的化合物及其药学上可接受的盐，酯和水合物与药物组合物和治疗方法一起公开。该化合物可用作半胱天冬酶-3的抑制剂，其涉及调节凋亡。