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    Reversible fluorescence photoswitch based on dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems
    3.
    发明授权
    Reversible fluorescence photoswitch based on dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems 有权
    基于染料交联树枝状纳米簇的可逆荧光光电开关，用于生物体系的高对比度成像

    公开(公告)号：US08697813B2

    公开(公告)日：2014-04-15

    申请号：US13218608

    申请日：2011-08-26

    申请人： Yoonkyung Kim ,  Hye-youn Jung ,  Bong Hyun Chung

    发明人： Yoonkyung Kim ,  Hye-youn Jung ,  Bong Hyun Chung

    IPC分类号： C08F283/04 ,  C08G69/48 ,  C08G73/10 ,  C08L77/00 ,  C08L79/08 ,  G02B5/23

    CPC分类号： B82Y15/00 ,  C09B69/00

    摘要： The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.

    摘要翻译： 本发明涉及一种基于染料交联树枝状纳米团簇的可逆荧光光电开关，用于生物体系的高对比度成像。 根据本发明的树枝状纳米团簇由两个或更多个交联的树枝状聚合物组成，从而整体上具有球状，从而提高荧光强度并提高单体树枝状大分子的检测灵敏度。 此外，发现根据本发明的树突状纳米簇独立地通过皮肤渗透和显微注射而内在化为活的斑马鱼。 此外，根据本发明的树突状纳米簇显示低毒性，因此其可用于体内和体外成像以及离体细胞追踪应用。

    Reversible Fluorescence Photoswitch based on Dye-Crosslinked Dendritic Nanoclusters for High-Contrast Imaging of Living Biological Systems
    4.
    发明申请
    Reversible Fluorescence Photoswitch based on Dye-Crosslinked Dendritic Nanoclusters for High-Contrast Imaging of Living Biological Systems 有权
    基于染料交联树枝状纳米团簇的可逆荧光光电开关，用于生物生物系统的高对比度成像

    公开(公告)号：US20120220734A1

    公开(公告)日：2012-08-30

    申请号：US13218608

    申请日：2011-08-26

    申请人： Yoonkyung Kim ,  Hye-Youn Jung ,  Bong Hyun Chung

    发明人： Yoonkyung Kim ,  Hye-Youn Jung ,  Bong Hyun Chung

    IPC分类号： C09B69/10 ,  B82Y5/00 ,  B82Y15/00

    CPC分类号： B82Y15/00 ,  C09B69/00

    摘要： The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.

    摘要翻译： 本发明涉及一种基于染料交联树枝状纳米团簇的可逆荧光光电开关，用于生物体系的高对比度成像。 根据本发明的树枝状纳米团簇由两个或更多个交联的树枝状聚合物组成，从而整体上具有球状，从而提高荧光强度并提高单体树枝状大分子的检测灵敏度。 此外，发现根据本发明的树突状纳米簇独立地通过皮肤渗透和显微注射而内在化为活的斑马鱼。 此外，根据本发明的树突状纳米簇显示低毒性，因此其可用于体内和体外成像以及离体细胞追踪应用。

    Dendrimer conjugates of agonists and antagonists of the GPCR superfamily
    6.
    发明授权
    Dendrimer conjugates of agonists and antagonists of the GPCR superfamily 失效
    GPCR超家族的激动剂和拮抗剂的树枝状结合物缀合物

    公开(公告)号：US08153781B2

    公开(公告)日：2012-04-10

    申请号：US12143451

    申请日：2008-06-20

    申请人： Kenneth A. Jacobson ,  Yoonkyung Kim ,  Athena Klutz ,  Beatrice Hechler ,  Christian Gachet

    发明人： Kenneth A. Jacobson ,  Yoonkyung Kim ,  Athena Klutz ,  Beatrice Hechler ,  Christian Gachet

    IPC分类号： C07H19/22

    CPC分类号： A61K49/0054 ,  A61K47/59 ,  A61K47/595 ,  A61K47/60 ,  A61K49/0041

    摘要： Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A1 adenosine receptor agonist having a purine nucleoside moiety and a functional group at the N6 position of the purine nucleoside moiety, wherein the functional group has the formula (I):N6H—Ar1—CH2—C(═O)NH—R1 (I), wherein Ar1 and R1 as defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.

    摘要翻译： 公开了包含树枝状大分子和配体的缀合物，其是G-蛋白质偶联受体（GPCR）超家族的受体的激动剂或拮抗剂的官能化同族物，其中所述官能化同系物是具有 嘌呤核苷部分和嘌呤核苷部分的N6位置的官能团，其中官能团具有式（I）：N6H-Ar1-CH2-C（= O）NH-R1（I），其中Ar1和R1 如本文所定义。 还公开了药物组合物，治疗各种疾病的方法和使用这种缀合物的诊断方法。