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公开(公告)号：US06372921B1
公开(公告)日：2002-04-16
申请号：US09444309
申请日：1999-11-22
IPC分类号： C07D31176
CPC分类号： C07D311/76 , C07C17/14 , C07C29/124 , C07C253/14 , C07C253/30 , C07C22/04 , C07C255/35 , C07C255/36 , C07C33/26 , C07C33/46
摘要： (1) Methods for producing isochromanone compounds from o-xylene compounds as starting compounds through &agr;-halogeno-o-xylene derivatives, &agr;-cyano-o-xylene derivatives, and &agr;-halogeno-&agr;′-cyano-o-xylene derivatives, and (2) methods for producing isochromanone compounds from o-xylene compounds as starting compounds through &agr;,&agr;′-dihalogeno-o-xylene derivatives, &agr;,&agr;′-dihydroxy-o-xylene derivatives, &agr;-halogeno-&agr;′-hydroxy-o-xylene derivatives and &agr;-cyano-&agr;′-hydroxy-o-xylene derivatives, and methods for producing these intermediate compounds.
摘要翻译： （1）通过α-卤代邻 - 二甲苯衍生物，α-氰基邻二甲苯衍生物和α-卤代-α'-氰基邻二甲苯衍生物从邻二甲苯化合物作为起始化合物生产异色酮化合物的方法， 和（2）通过α，α'-二卤代邻二甲苯衍生物，α，α'-二羟基邻二甲苯衍生物，α-卤代-α-羟基，邻二甲苯衍生物，由邻二甲苯化合物作为起始化合物生产异色酮化合物的方法 α-二甲苯衍生物和α-氰基-α'-羟基邻二甲苯衍生物，以及制备这些中间体化合物的方法。
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公开(公告)号：US06953859B2
公开(公告)日：2005-10-11
申请号：US10343607
申请日：2002-06-04
IPC分类号： C07D263/44
CPC分类号： C07D263/44
摘要： The object of the present invention is to produce a 5-alkyl-oxazolidin-2,4-dione by an industrially advantageous method. The invention relates to novel process for producing a high-purity 5-alkyl-oxazolidin-2,4-dione comprising the steps of reacting a 2-hydroxycarboxylic acid amide with a carbonic acid ester in the presence of a metal alcoholate, thereby completing the reaction in one step, and then isolating the reaction product by a neutralization crystallization method.
摘要翻译： 本发明的目的是通过工业上有利的方法制备5-烷基 - 恶唑烷-2,4-二酮。 本发明涉及生产高纯度5-烷基 - 恶唑烷-2,4-二酮的新方法，包括在金属醇化物存在下使2-羟基羧酸酰胺与碳酸酯反应的步骤，从而完成 一步反应，然后用中和结晶法分离反应产物。
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公开(公告)号：US20080085251A1
公开(公告)日：2008-04-10
申请号：US11792828
申请日：2005-12-20
申请人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
发明人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
CPC分类号： A61K8/4933 , A61Q5/04
摘要： Provided are hair processing agents capable of permanent waving hair even at a neutral to weakly acidic pH range that causes less irritation to the skin, and hair processing agents in which an unpleasant odor is masked. Hair processing agents contain at least one compound represented by the formula (2). Hair processing agents contain a compound of the formula (2) and at least one compound (ii) selected from thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine, salts thereof and ester derivatives thereof. Hair processing agents contain a compound of the formula (2), a surfactant and water, and are emulsified. Hair processing agents contain a compound of the formula (2) and a specific perfume. wherein X is a structure selected from —O—, —S—, —NH— and —NR1—; R1 is an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; in the formula (1), Z is a divalent organic residue having at least one mercapto group; in the formula (2), R is a divalent organic residue optionally having a mercapto group; and R2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms.
摘要翻译： 提供即使在对皮肤刺激较少的中性至弱酸性pH范围也能永久挥发头发的头发加工剂，以及掩盖有令人不愉快的气味的毛发加工剂。 头发处理剂含有至少一种式（2）表示的化合物。 头发处理剂含有式（2）化合物和至少一种选自巯基乙酸，硫代乳酸，半胱氨酸，乙酰半胱氨酸，半胱胺，酰基半胱胺，其盐和其酯衍生物的化合物（ii）。 头发处理剂含有式（2）的化合物，表面活性剂和水，并被乳化。 头发处理剂含有式（2）的化合物和特定的香料。 其中X是选自-O - ， - S - ， - NH-和-NR 1 - 的结构。 R 1是1至6个碳原子的烷基; Y是氧原子或硫原子; 在式（1）中，Z是具有至少一个巯基的二价有机残基; 在式（2）中，R是任选具有巯基的二价有机残基; R 2是氢原子或1〜6个碳原子的烷基。
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4.发明授权公开(公告)号：US08066977B2
公开(公告)日：2011-11-29
申请号：US11884413
申请日：2006-05-25
申请人： Akira Shibuya , Shinichi Yorozuya , Makoto Saito
发明人： Akira Shibuya , Shinichi Yorozuya , Makoto Saito
IPC分类号： A61Q5/04
CPC分类号： A61Q5/04 , A61K8/4933
摘要： Disclosed is an agent for permanent hair waving that can realize permanent hair waving even in the neutral to weakly acidic pH range in which irritation particularly to the skin is not significant. The agent for permanent hair waving includes at least one heterocyclic mercapto compound represented by formula (1): wherein R1 and R2 each independently represent a hydrogen atom or an optionally substituted alkyl group having 1 to 5 carbon atoms; X represents —O—, —S—, —NH—, or —NR3—; R3 represents an alkyl group having 1 to 5 carbon atoms; n is an integer of 0 to 2; and, when n is 2, group SH may be attached to any carbon atom of an alkylene group having 2 carbon atoms.
摘要翻译： 公开了即使在特别是对皮肤的刺激不显着的中性至弱酸性pH范围内也能实现永久性头发挥发的药剂。 永久性头发挥发剂包括至少一种由式（1）表示的杂环巯基化合物：其中R 1和R 2各自独立地表示氢原子或任选取代的具有1至5个碳原子的烷基; X表示-O - ， - S - ， - NH-或-NR 3 - ; R3表示碳原子数1〜5的烷基。 n为0〜2的整数， 并且当n为2时，基团SH可以连接到具有2个碳原子的亚烷基的任何碳原子上。
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5.发明申请公开(公告)号：US20090208439A1
公开(公告)日：2009-08-20
申请号：US11884413
申请日：2006-05-25
申请人： Akira Shibuya , Shinichi Yorozuya , Makoto Saito
发明人： Akira Shibuya , Shinichi Yorozuya , Makoto Saito
IPC分类号： A61K8/49 , C07D233/40 , A61Q5/04
CPC分类号： A61Q5/04 , A61K8/4933
摘要： Disclosed is an agent for permanent hair waving that can realize permanent hair waving even in the neutral to weakly acidic pH range in which irritation particularly to the skin is not significant. The agent for permanent hair waving includes at least one heterocyclic mercapto compound represented by formula (1): wherein R1 and R2 each independently represent a hydrogen atom or an optionally substituted alkyl group having 1 to 5 carbon atoms; X represents —O—, —S—, —NH—, or —NR3—; R3 represents an alkyl group having 1 to 5 carbon atoms; n is an integer of 0 to 2; and, when n is 2, group SH may be attached to any carbon atom of an alkylene group having 2 carbon atoms.
摘要翻译： 公开了即使在特别是对皮肤的刺激不显着的中性至弱酸性pH范围内也能实现永久性头发挥发的药剂。 永久性头发挥发剂包括至少一种由式（1）表示的杂环巯基化合物：其中R 1和R 2各自独立地表示氢原子或任选取代的具有1至5个碳原子的烷基; X表示-O - ， - S - ， - NH-或-NR 3 - ; R3表示碳原子数1〜5的烷基。 n为0〜2的整数， 并且当n为2时，基团SH可以连接到具有2个碳原子的亚烷基的任何碳原子上。
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公开(公告)号：US08961946B2
公开(公告)日：2015-02-24
申请号：US11792828
申请日：2005-12-20
申请人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
发明人： Akira Shibuya , Hidemasa Aoki , Makoto Saito , Motoaki Kamachi , Atsushi Tsuchiya , Akio Okamura
CPC分类号： A61K8/4933 , A61Q5/04
摘要： Provided are hair processing agents capable of permanent waving hair even at a neutral to weakly acidic pH range that causes less irritation to the skin, and hair processing agents in which an unpleasant odor is masked. Hair processing agents contain at least one compound represented by the formula (2). Hair processing agents contain a compound of the formula (2) and at least one compound (ii) selected from thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine, salts thereof and ester derivatives thereof. Hair processing agents contain a compound of the formula (2), a surfactant and water, and are emulsified. Hair processing agents contain a compound of the formula (2) and a specific perfume. wherein X is a structure selected from —O—, —S—, —NH— and —NR1—; R1 is an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; in the formula (1), Z is a divalent organic residue having at least one mercapto group; in the formula (2), R is a divalent organic residue optionally having a mercapto group; and R2 is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms.
摘要翻译： 提供即使在对皮肤刺激较少的中性至弱酸性pH范围也能永久挥发头发的头发加工剂，以及掩盖有令人不愉快的气味的毛发加工剂。 头发处理剂含有至少一种式（2）表示的化合物。 头发处理剂含有式（2）化合物和至少一种选自巯基乙酸，硫代乳酸，半胱氨酸，乙酰半胱氨酸，半胱胺，酰基半胱胺，其盐和其酯衍生物的化合物（ii）。 头发处理剂含有式（2）的化合物，表面活性剂和水，并被乳化。 头发处理剂含有式（2）的化合物和特定的香料。 其中X是选自-O - ， - S - ， - NH-和-NR 1 - 的结构。 R1是1-6个碳原子的烷基; Y是氧原子或硫原子; 在式（1）中，Z是具有至少一个巯基的二价有机残基; 在式（2）中，R是任选具有巯基的二价有机残基; R2为氢原子或碳原子数1〜6的烷基。
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公开(公告)号：US20080131389A1
公开(公告)日：2008-06-05
申请号：US11793798
申请日：2006-02-03
申请人： Akira Shibuya , Makoto Saito
发明人： Akira Shibuya , Makoto Saito
摘要： A hair relaxer includes at least one specific mercapto compound such as 2-methoxyethyl 3-mercaptopropionate, 2-mercapto-4-butanolide and 2-mercapto-4-butyrolactam. The hair relaxer can achieve an excellent effect of shaping and relaxing hair over a wide range of pH values from weak acidity to weak alkalinity. In particular, the hair relaxer displays a more superior hair shaping and relaxing performance in a weakly acidic to neutral pH range. Consequently, the hair relaxer can drastically reduce the damage to the hair and skin and can reliably perform straightening, uncurling, curling and other hair processing.
摘要翻译： 头发松弛剂包括至少一种特定的巯基化合物，例如3-巯基丙酸2-甲氧基乙酯，2-巯基-4-丁醇酯和2-巯基-4-丁内酰胺。 头发松弛剂可以在从弱酸性到弱碱性的广泛pH值范围内实现成型和松弛头发的优异效果。 特别地，头发松弛剂在弱酸性至中性pH范围内显示出更优异的头发成型和松弛性能。 因此，头发松弛剂可以大大降低对头发和皮肤的损伤，并可以可靠地进行矫直，卷曲，卷曲和其它头发处理。
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公开(公告)号：US20080031839A1
公开(公告)日：2008-02-07
申请号：US11631027
申请日：2005-06-28
申请人： Akira Shibuya , Makoto Saito , Hiroshi Ishit
发明人： Akira Shibuya , Makoto Saito , Hiroshi Ishit
摘要： An agent for permanent hair processing is disclosed that can shape the hair even in a neutral to slightly acidic pH region. The agent contains one or more compounds represented by the following formula (1) and/or formula (2): wherein R1 is a hydrogen atom or an alkyl group of 1 to 5 carbon atoms, R2 is an alkoxyalkyl group having a total of 3 to 15 carbon atoms, and the alkylene portion of R2 may contain an ether bond(s); wherein R3 is an alkoxyalkyl group having a total of 3 to 15 carbon atoms, and the alkylene portion of R3 may contain an ether bond(s).
摘要翻译： 公开了一种用于永久性毛发加工的试剂，即使在中性至微酸性pH区域中也能使头发成型。 该试剂含有一种或多种由下式（1）和/或式（2）表示的化合物：其中R 1是氢原子或1至5个碳原子的烷基， SUP> 2是总共3至15个碳原子的烷氧基烷基，R 2的亚烷基部分可以含有醚键; 其中R 3是总共3至15个碳原子的烷氧基烷基，R 3的亚烷基部分可以含有醚键。
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公开(公告)号：US20110004017A1
公开(公告)日：2011-01-06
申请号：US12677251
申请日：2008-09-19
申请人： Akira Shibuya , Hidemasa Aoki
发明人： Akira Shibuya , Hidemasa Aoki
IPC分类号： C07B53/00
CPC分类号： C07C319/04 , C07B45/06 , C07C2601/10 , C07C2601/16 , C07C323/52 , C07C323/56
摘要： The invention relates to a method for efficiently producing β-mercaptocarboxylic acids using a solid acid catalyst such as zeolite, which product corresponds to respective starting materials selected from α,β-unsaturated carboxylic acids (α,β-unsaturated carboxylic acid, α,β-unsaturated carboxylic acid ester, α,β-unsaturated amide, α,β-unsaturated aldehide and α,β-unsaturated ketone) and hydrogen sulfides (hydrogen sulfide, sulfide salt and hydrosulfide salt), wherein a solvent compatible with water is used in the reaction. According to the invention, β-mercaptocarboxylic acids which are useful as additives in synthetic materials for pharmaceutical or agricultural agents and in polymer compounds can be industrially produced efficiently by using easily available α,β-unsaturated carboxylic acid (such as crotonic acid) at high yield.
摘要翻译： 本发明涉及一种使用固体酸催化剂如沸石有效生产β-巯基羧酸的方法，该产物对应于选自α，β-不饱和羧酸（α，β-不饱和羧酸， α，β-不饱和羧酸酯，α，bgr-不饱和酰胺，α，bgr-不饱和醛和α，bgr-不饱和酮）和硫化氢（硫化氢，硫化物盐和氢硫化物盐），其中a 在反应中使用与水相容的溶剂。 根据本发明，可用作药物或农药合成材料和聚合物化合物的合成材料中的添加剂的β-巯基羧酸可以通过使用容易获得的α，β-不饱和羧酸（例如巴豆酸）工业上有效地生产， 以高产量。
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公开(公告)号：US5687001A
公开(公告)日：1997-11-11
申请号：US7143
申请日：1993-01-21
CPC分类号： H04N1/40043 , H04N1/40056 , H04N1/40081
摘要： The invention makes it possible to drive a halftone image device and achieve high halftone reproduction by allowing at least one of the leading and trailing edges of a pulse width-modulated signal applied to a recording head, or forming amplitude- and width-modulated pulses, respectively, as driving pulses for placing one dot under halftone control, and changing pulse width modulation in a stepwise manner, using the pulse width of the amplitude-modulated pulse as a unit pulse width. The invention intends to achieve high-voltage and high-speed pulse output and low power consumption by converting input data such as halftone image data to a voltage signal, superposing pulse voltages of opposite polarities and applying the resulting signal to a switching circuit constituting an output state in the form of a switching signal, and also makes it possible to achieve high speed and high-voltage driving by connecting at least one of equivalent two-terminal elements in series to at least one of the respective driving elements of a complementary FET driving circuit, said equivalent two-terminal elements are each turned on with a current of a certain or higher value passing therethrough to show constant-voltage characteristics and turned off with a current of a certain or lower value passing therethrough to become a constant resistance.
摘要翻译： 本发明通过允许施加到记录头的脉冲宽度调制信号的前沿和后沿中的至少一个或形成幅度和宽度调制脉冲，驱动半色调图像装置并实现高半色调再现， 作为用于在半色调控制下放置一个点的驱动脉冲，并且以幅度调制脉冲的脉冲宽度为单位脉冲宽度逐步改变脉宽调制。 本发明旨在通过将诸如半色调图像数据的输入数据转换为电压信号来实现高电压和高速脉冲输出以及低功耗，从而叠加具有相反极性的脉冲电压，并将所得到的信号施加到构成输出的开关电路 状态，并且还可以通过将等效的两端元件中的至少一个串联连接到互补FET驱动的各个驱动元件中的至少一个而实现高速和高电压驱动 电路中，所述等效的两端子元件各自以通过其中的一定或更高值的电流接通以显示恒定电压特性，并且通过其中通过的一定或更低值的电流变为恒定电阻。
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