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公开(公告)号：US5837687A
公开(公告)日：1998-11-17
申请号：US406053
申请日：1995-03-17
CPC分类号： C07K5/0819 , C07K5/0606 , C07K5/06086 , C07K5/06104 , C07K5/06113 , A61K38/00 , Y02P20/55
摘要： Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group, and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.
摘要翻译： 公开了由式（I）表示的氮杂肽衍生物：其中A表示直接键，α-氨基酸或二肽的残基; R1表示氢原子或末端氨基的保护基; R2表示苯基或被一个或两个取代基取代的苯基，所述取代基选自低级烷基，卤素原子，可被保护的羟基，硝基，可被保护的氨基和全卤代低级烷基 ; R3表示羟基或末端羧基的保护基及其盐，和包含式（I）所示的氮杂多肽衍生物或其盐的呼吸器官，哮喘和支气管痉挛的神经炎症的治疗剂 作为活性成分。
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公开(公告)号：US5965538A
公开(公告)日：1999-10-12
申请号：US138656
申请日：1998-08-24
CPC分类号： C07K5/0819 , C07K5/0606 , C07K5/06086 , C07K5/06104 , C07K5/06113 , A61K38/00 , Y02P20/55
摘要： Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group,and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.
摘要翻译： 公开了由式（I）表示的氮杂肽衍生物：其中A表示直接键，α-氨基酸或二肽的残基; R1表示氢原子或末端氨基的保护基; R2表示苯基或被一个或两个取代基取代的苯基，所述取代基选自低级烷基，卤素原子，可被保护的羟基，硝基，可被保护的氨基和全卤代低级烷基 ; R3表示羟基或末端羧基的保护基及其盐，和包含式（I）所示的氮杂多肽衍生物或其盐的呼吸器官，哮喘和支气管痉挛的神经炎症的治疗剂 作为活性成分。
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公开(公告)号：US5324728A
公开(公告)日：1994-06-28
申请号：US801501
申请日：1991-12-02
申请人： Yasuo Sekine , Tetsuaki Yamaura , Masato Nishimura , Eri Kojima , Yasuko Emoto , Yasushi Higashide
发明人： Yasuo Sekine , Tetsuaki Yamaura , Masato Nishimura , Eri Kojima , Yasuko Emoto , Yasushi Higashide
IPC分类号： A61K31/16 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/495 , A61P37/08 , A61P43/00 , C07C233/22 , C07C235/66 , C07C317/28 , C07C323/25 , C07C323/41 , C07C323/42 , C07D211/46 , C07D211/54 , C07D213/30 , C07D213/32 , C07D213/34 , C07D213/38 , C07D233/60 , C07D295/12 , C07D295/13 , C07D295/22 , C07D307/38 , C07D307/42 , C07D317/56 , C07D333/16 , C07D333/18 , C07D333/28 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/04 , C07D409/12 , C07D401/00 , C07D241/04 , C07D295/00
CPC分类号： C07D213/30 , C07D211/46 , C07D211/54 , C07D213/32 , C07D213/38 , C07D295/13 , C07D307/38 , C07D317/56 , C07D333/18 , C07D333/28 , C07D401/12
摘要： A naphthoic acid derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group;R.sub.4 is a hydrogen atom or a lower alkyl group;R.sub.5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group;X is a group ##STR2## a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group ##STR3## --R.sub.8 --NH-- or --NH--R.sub.8, where R.sub.6 and R.sub.7 are each a hydrogen atom or a lower alkyl group and R.sub.8 is a cycloalkylene group, or R.sub.6 and R.sub.7, together with R.sub.4, may form an alkylene group of 1-3 carbon atoms;Y is --S(O).sub.p --, --(CH.sub.2).sub.n -- or --O--;Z is a substituted or unsubstituted alkylene group or a single bond;l is an integer of 0-4;m is an integer of 0-8;n is 0 or 1;p is an integer of 0-2; andg is 0 or 1.The compound is useful as an antiallergic agent.
摘要翻译： 由以下通式表示的萘甲酸衍生物或其盐：其中R 1，R 2和R 3各自独立地为氢原子，卤素原子，羟基，低级烷基，低级烷氧基， 低级烷酰氧基，羟基低级烷基，低级烷氧基 - 低级烷基，低级烷酰氧基 - 低级烷基或芳烷氧基; R4是氢原子或低级烷基; R5是取代或未取代的芳基或取代或未取代的杂芳基; X是亚环烷基，二价含氮杂环基或基团-R8-NH-或-NH-R8基团，其中R6和R7各自为氢原子或低级烷基 并且R 8为亚环烷基，或者R 6和R 7与R 4一起可以形成1-3个碳原子的亚烷基; Y是-S（O）对 - ， - （CH 2）n - 或-O-; Z是取代或未取代的亚烷基或单键; l是0-4的整数; m为0-8的整数; n为0或1; p是0-2的整数; 并且g为0或1.该化合物可用作抗过敏剂。
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