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1.发明申请Process for Producing (Z)-1-Phenyl-1-(N,N-Diethylaminocarbonyl)-2-Phthalimidomethylcyclopropane 失效制备（Z）-1-苯基-1-（N，N-二乙基氨基羰基）-2-苯二甲酰亚氨基甲基环丙烷的方法公开(公告)号：US20090292127A1
公开(公告)日：2009-11-26
申请号：US11795860
申请日：2007-01-26
Applicant: Yoshihide Niimoto , Hiroharu Kumazawa , Koh Kawami
Inventor： Yoshihide Niimoto , Hiroharu Kumazawa , Koh Kawami
IPC: C07D209/48
CPC classification number: C07D307/93 , C07D209/48
Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcyclopropane with an orthoester and a brønsted acid, and reacting the reaction product with a phthalimidating agent; and a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcyclopropane hydrochloride through the above process.
Abstract translation: 本发明提供（Z）-1-苯基-1-（N，N-二乙基氨基羰基）-2-苯二甲酰亚氨基甲基环丙烷的制备方法，其包括使（Z）-1-苯基-1-（N，N-二乙基氨基羰基） -2-羟基甲基环丙烷与原酸酯和布朗斯台德酸反应，并使反应产物与邻苯二甲酰亚胺化试剂反应; 以及通过上述方法制备（Z）-1-苯基-1-（N，N-二乙基氨基羰基）-2-氨基甲基环丙烷盐酸盐的方法。
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2.发明授权Process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2- phthalimidomethylcyclopropane 失效（Z）-1-苯基-1-（N，N-二乙基氨基羰基）-2-邻苯二甲酰亚氨基甲基环丙烷的制备方法公开(公告)号：US07943785B2
公开(公告)日：2011-05-17
申请号：US11795860
申请日：2007-01-26
Applicant: Yoshihide Niimoto , Hiroharu Kumazawa , Koh Kawami
Inventor： Yoshihide Niimoto , Hiroharu Kumazawa , Koh Kawami
IPC: C07C233/58 , C07D209/48
CPC classification number: C07D307/93 , C07D209/48
Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcyclopropane with an orthoester and a brønsted acid, and reacting the reaction product with a phthalimidating agent; and a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcyclopropane hydrochloride through the above process.
Abstract translation: 本发明提供（Z）-1-苯基-1-（N，N-二乙基氨基羰基）-2-苯二甲酰亚氨基甲基环丙烷的制备方法，其包括使（Z）-1-苯基-1-（N，N-二乙基氨基羰基） -2-羟基甲基环丙烷与原酸酯和布朗斯台德酸反应，并使反应产物与邻苯二甲酰亚胺化试剂反应; 以及通过上述方法制备（Z）-1-苯基-1-（N，N-二乙基氨基羰基）-2-氨基甲基环丙烷盐酸盐的方法。
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![Process for Producing 2-Oxo-1-Phenyl-3-Oxabicyclo[3.1.0]Hexane](/abs-image/US/2008/03/13/US20080064885A1/abs.jpg.150x150.jpg)
3.发明申请公开(公告)号：US20080064885A1
公开(公告)日：2008-03-13
申请号：US11629515
申请日：2005-06-14
Applicant: Yoshihide Niimoto , Hiroharu Kumazawa , Osamu Tokuda , Koh Kawami
Inventor： Yoshihide Niimoto , Hiroharu Kumazawa , Osamu Tokuda , Koh Kawami
IPC: C07D307/93
CPC classification number: C07D307/93
Abstract: The present invention provides a process for producing 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane which comprises reacting phenylacetonitrile with epichlorohydrin in the presence of sodium hydride. According to the present invention, 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane can be produced safely, easily and industrially advantageously.
Abstract translation: 本发明提供2-氧代-1-苯基-3-氧杂双环[3.1.0]己烷的制备方法，其包括在氢化钠存在下使苯基乙腈与表氯醇反应。 根据本发明，可以安全，容易和工业上有利地制备2-氧代-1-苯基-3-氧杂双环[3.1.0]己烷。
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公开(公告)号：US20050137419A1
公开(公告)日：2005-06-23
申请号：US11016441
申请日：2004-12-17
Applicant: Koh Kawami , Osamu Tokuda , Yoshihide Niimoto
Inventor： Koh Kawami , Osamu Tokuda , Yoshihide Niimoto
IPC: C07C319/24 , C07C323/66 , C07C327/22 , C07F9/22 , C07C319/22
CPC classification number: C07C319/24 , C07C323/66
Abstract: This invention relates to a process for producing a substantially pure disulfide compound of Formula II as disclosed herein, such as disodium 2,2′-dithiobis ethane sulfonate, by an efficient procedure from available, relatively inexpensive raw materials.
Abstract translation: 本发明涉及通过有效的方法从现有的相对便宜的原料生产基本上纯的二硫化物，如本文所公开的二硫化物化合物，例如2,2'-二硫代双乙烷磺酸二钠。
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Patent Agency Ranking
5.发明申请Process For Producing (Z)-1-Phenyl-1-Diethylaminocarbonyl-2-Aminomethylcyclopropane Hydrochloride 失效制备（Z）-1-苯基-1-二乙基氨基羰基-2-氨基甲基环丙烷盐酸盐的方法公开(公告)号：US20080051604A1
公开(公告)日：2008-02-28
申请号：US11630253
申请日：2005-06-23
Applicant: Yoshihide Niimoto , Hiroharu Kumazawa , Osamu Tokuda , Fumiaki Ibukuro
Inventor： Yoshihide Niimoto , Hiroharu Kumazawa , Osamu Tokuda , Fumiaki Ibukuro
IPC: C07C231/12
CPC classification number: C07C231/12 , C07C2601/02 , C07C237/24
Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane or hydrochloride thereof, which comprises a step of reacting (Z)-1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethylcyclopropane by contacting said compound with an aqueous methylamine solution having a concentration of from 1 to 25% by weight to obtain (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane.
Abstract translation: 本发明提供了（Z）-1-苯基-1-二乙基氨基羰基-2-氨基甲基环丙烷或其盐酸盐的制备方法，其包括使（Z）-1-苯基-1-二乙基氨基羰基-2-苯二酰亚氨基甲基环丙烷与 所述化合物与甲基胺水溶液的浓度为1至25重量％以获得（Z）-1-苯基-1-二乙基氨基羰基-2-氨基甲基环丙烷。
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公开(公告)号：US07053240B2
公开(公告)日：2006-05-30
申请号：US11016441
申请日：2004-12-17
Applicant: Koh Kawami , Osamu Tokuda , Yoshihide Niimoto
Inventor： Koh Kawami , Osamu Tokuda , Yoshihide Niimoto
IPC: C07F9/38 , C07C309/20 , C07C323/52
CPC classification number: C07C319/24 , C07C323/66
Abstract: This invention relates to a process for producing a substantially pure disulfide compound of Formula II as disclosed herein, such as disodium 2,2′-dithiobis ethane sulfonate, by an efficient procedure from available, relatively inexpensive raw materials.
Abstract translation: 本发明涉及通过有效的方法从现有的相对便宜的原料生产基本上纯的二硫化物，如本文所公开的二硫化物化合物，例如2,2'-二硫代双乙烷磺酸二钠。
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7.发明授权Process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane hydrochloride 失效（Z）-1-苯基-1-二乙基氨基羰基-2-氨基甲基环丙烷盐酸盐的制备方法公开(公告)号：US07592485B2
公开(公告)日：2009-09-22
申请号：US11630253
申请日：2005-06-23
Applicant: Yoshihide Niimoto , Hiroharu Kumazawa , Osamu Tokuda , Fumiaki Ibukuro
Inventor： Yoshihide Niimoto , Hiroharu Kumazawa , Osamu Tokuda , Fumiaki Ibukuro
IPC: C07C231/12
CPC classification number: C07C231/12 , C07C2601/02 , C07C237/24
Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane or hydrochloride thereof, which comprises a step of reacting (Z)-1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethylcyclopropane by contacting said compound with an aqueous methylamine solution having a concentration of from 1 to 25% by weight to obtain (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane.
Abstract translation: 本发明提供了（Z）-1-苯基-1-二乙基氨基羰基-2-氨基甲基环丙烷或其盐酸盐的制备方法，其包括使（Z）-1-苯基-1-二乙基氨基羰基-2-苯二酰亚氨基甲基环丙烷与 所述化合物与甲基胺水溶液的浓度为1至25重量％以获得（Z）-1-苯基-1-二乙基氨基羰基-2-氨基甲基环丙烷。
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8.发明授权Process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane 失效（Z）-1-苯基-1-二乙基氨基羰基-2-羟基甲基环丙烷的制备方法公开(公告)号：US07432396B2
公开(公告)日：2008-10-07
申请号：US11630344
申请日：2005-06-23
Applicant: Yoshihide Niimoto , Hiroharu Kumazawa
Inventor： Yoshihide Niimoto , Hiroharu Kumazawa
IPC: C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
CPC classification number: C07C231/02 , C07C235/40
Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane, which comprises reacting 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane with diethylamine in the presence of alkali metal alkoxide.
Abstract translation: 本发明提供（Z）-1-苯基-1-二乙基氨基羰基-2-羟甲基环丙烷的制备方法，该方法包括使2-氧代-1-苯基-3-氧杂双环[3.1.0]己烷与二乙胺在 碱金属醇盐。
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9.发明申请Process for Producing (Z)-1-Phenyl-1-Diethylaminocarbonyl-2-Hydroxymethylcyclopropane 失效（Z）-1-苯基-1-二乙基氨基羰基-2-羟甲基环丙烷的制备方法公开(公告)号：US20070249864A1
公开(公告)日：2007-10-25
申请号：US11630344
申请日：2005-06-23
Applicant: Yoshihide Niimoto , Hiroharu Kumazawa
Inventor： Yoshihide Niimoto , Hiroharu Kumazawa
IPC: C07C231/02 , C07C235/40
CPC classification number: C07C231/02 , C07C235/40
Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane, which comprises reacting 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane with diethylamine in the presence of alkali metal alkoxide.
Abstract translation: 本发明提供（Z）-1-苯基-1-二乙基氨基羰基-2-羟甲基环丙烷的制备方法，该方法包括使2-氧代-1-苯基-3-氧杂双环[3.1.0]己烷与二乙胺在 碱金属醇盐。
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