公开(公告)号：US06245795B1

公开(公告)日：2001-06-12

申请号：US09402241

申请日：1999-09-29

申请人： Yoshito Takahashi ,  Masaki Yoshida ,  Shintaro Inoue

发明人： Yoshito Takahashi ,  Masaki Yoshida ,  Shintaro Inoue

IPC分类号： A61K31415

CPC分类号： A61Q19/10 ,  A61K8/44 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4973 ,  A61K8/97 ,  A61Q19/02

摘要： An object of the present invention is to provide a melanogenesis inhibitor and a skin cosmetic composition, which are superior in the effect of preventing pigmentation due to inflammation by selectively inhibiting stimulation of histamine to melanocytes. The object is accomplished by containing a histamine H2 receptor antagonist itself, cable of selectively blocking histamine H2 receptors, or simultaneously containing the histamine H2 receptor antagonist and at least one of histamine release inhibitors and histamine H3 receptor agonists.

摘要翻译： 本发明的目的是提供一种黑素生成抑制剂和皮肤化妆品组合物，其通过选择性地抑制组胺对黑素细胞的刺激而具有优异的防止由于炎症引起的色素沉积的效果。目的是通过含有组胺H 2受体拮抗剂 本身，选择性阻断组胺H2受体或同时含有组胺H2受体拮抗剂和组胺释放抑制剂和组胺H3受体激动剂中的至少一种的电缆。

公开(公告)号：US4943449A

公开(公告)日：1990-07-24

申请号：US91793

申请日：1987-09-01

申请人： Shizuo Aishima ,  Yoshito Takahashi ,  Masaki Kosemura ,  Masaaki Ohkawara

发明人： Shizuo Aishima ,  Yoshito Takahashi ,  Masaki Kosemura ,  Masaaki Ohkawara

IPC分类号： A61J3/07 ,  A01N25/28 ,  A23K1/16 ,  A23K1/18 ,  A23L1/00 ,  A23P1/04 ,  A61K9/50 ,  B01J13/04 ,  B01J13/12

CPC分类号： A61K9/5015 ,  A61K9/5052 ,  A61K9/5089 ,  B01J13/04 ,  B01J13/125 ,  Y10S426/805 ,  Y10T428/2989

摘要： Process for producing microcapsules. Wax or a mixture of wax and protein is dissolved in a mixed solvent consisting of an organic solvent and water, the surfaces of particles of a core substance are wetted with the resulting solution at temperatures of 45 deg.C or below to selectively deposit the wax or the mixture of wax and protein on the particle surfaces and allow them to coat the particle surfaces. And then a slurry containing the particles is subjected to a solvent removal treatment.