公开(公告)号：US20110142955A1

公开(公告)日：2011-06-16

申请号：US13054367

申请日：2009-07-15

申请人： Yoshiya Sato ,  Kaiissar Mannoor ,  Hisami Watanabe ,  Kikuji Yamaguchi ,  Mayu Tsukamoto

发明人： Yoshiya Sato ,  Kaiissar Mannoor ,  Hisami Watanabe ,  Kikuji Yamaguchi ,  Mayu Tsukamoto

IPC分类号： A61K35/64 ,  A61P37/02

CPC分类号： A61K35/644 ,  A23L2/52 ,  A23L21/20 ,  A23L33/10

摘要： The present invention relates to an agent for ameliorating stress-induced immune function modulation which comprises royal jelly. In addition, the present invention provides an anti-stress agent, pharmaceutical, food or beverage, or food additive that contains royal jelly as an active ingredient thereof and prevents or alleviates various somatic symptoms caused by stress.

摘要翻译： 本发明涉及一种用于改善包含蜂王浆的应激诱导的免疫功能调节剂。 此外，本发明提供了含有蜂王浆作为其活性成分的抗应激剂，药物，食品或饮料或食品添加剂，并且防止或减轻由应力引起的各种体细胞症状。

公开(公告)号：US20100256346A1

公开(公告)日：2010-10-07

申请号：US12087180

申请日：2006-12-25

申请人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

发明人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

IPC分类号： C07H15/10

CPC分类号： A61K36/899 ,  C07H15/10

摘要： To provide a pharmaceutical composition comprising a ceramide-related substance having little adverse side effects as an active ingredient by using a raw material that is highly safe to a human body and is inexpensive. A pharmaceutical composition comprising at least one sphingoglycolipid derivative that is produced from a beer waste and is represented by the formula below as an active ingredient: wherein R3 represents H or OH; R4 is as defined by (a) or (b): (a) when R3 is H, R4 represents (CH2)13CH3 or (CH2)6CH═CHCH2CH═CH(CH2)4CH3; and (b) when R3 is OH, R4 represents (CH2)yCH3 (where Y represents an integer of 13 to 21) or (CH2)z1CH═CH(CH2)Z2CH3 (where Z1 and Z2 independently represent 0 or a natural number, provided that Z1+Z2=19).

摘要翻译： 为了提供一种药物组合物，其通过使用对人体高度安全的原料廉价地提供作为有效成分的，具有很少副作用的神经酰胺相关物质。 一种药物组合物，其包含至少一种由啤酒废物产生的神经鞘糖脂衍生物，并由下式表示为活性成分：其中R 3表示H或OH; R 4如（a）或（b）所定义：（a）当R 3为H时，R 4表示（CH 2）13 CH 3或（CH 2）6 CH = CHCH 2 CH = CH（CH 2）4 CH 3; 和（b）当R3为OH时，R4表示（CH2）yCH3（其中Y表示13-21的整数）或（CH2）z1CH = CH（CH2）Z2CH3（其中Z1和Z2独立地表示0或自然数， 条件是Z1 + Z2 = 19）。

公开(公告)号：US20130022641A1

公开(公告)日：2013-01-24

申请号：US13630850

申请日：2012-09-28

申请人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

发明人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

IPC分类号： A61K31/7028 ,  A61P37/04 ,  A61P35/00 ,  C07H15/10

CPC分类号： A61K36/899 ,  C07H15/10

摘要： To provide a pharmaceutical composition comprising a ceramide-related substance having little adverse side effects as an active ingredient by using a raw material that is highly safe to a human body and is inexpensive. A pharmaceutical composition comprising at least one sphingoglycolipid derivative that is produced from a beer waste and is represented by the formula below as an active ingredient: wherein R3 represents H or OH; R4 is as defined by (a) or (b) (a) when R3 is H, R4 represents (CH2)13CH3 or (CH2)6CH═CHCH2CH═CH(CH2)4CH3; and (b) when R3 is OH, R4 represents (CH2)yCH3 (where Y represents an integer of 13 to 21) or (CH2)Z1CH═CH(CH2)Z2CH3 (where Z1 and Z2 independently represent 0 or a natural number, provided that Z1+Z2=19).

摘要翻译： 为了提供一种药物组合物，其通过使用对人体高度安全的原料廉价地提供作为有效成分的，具有很少副作用的神经酰胺相关物质。 一种药物组合物，其包含至少一种由啤酒废物产生的神经鞘糖脂衍生物，并由下式表示为活性成分：其中R 3表示H或OH; 当R 3为H时，R 4如（a）或（b）（a）所定义，R 4表示（CH 2）13 CH 3或（CH 2）6 CH = CHCH 2 CH = CH（CH 2）4 CH 3; 和（b）当R3是OH时，R4表示（CH2）yCH3（其中Y表示13-21的整数）或（CH2）Z1CH = CH（CH2）Z2CH3（其中Z1和Z2独立地表示0或自然数， 条件是Z1 + Z2 = 19）。