公开(公告)号：US20140331894A1

公开(公告)日：2014-11-13

申请号：US14359520

申请日：2012-11-21

申请人： Young Chang Ah ,  Sung Yeon Cho ,  In Seok Hwang ,  Sun Young Park ,  Hyun Ju Ko ,  Hyuk Kim ,  Min Jung Kwon ,  Won Seok Park

发明人： Young Chang Ah ,  Sung Yeon Cho ,  In Seok Hwang ,  Sun Young Park ,  Hyun Ju Ko ,  Hyuk Kim ,  Min Jung Kwon ,  Won Seok Park

IPC分类号： C08L5/08

CPC分类号： C08L5/08 ,  A61K9/06 ,  A61K47/36 ,  A61L15/28 ,  A61L27/20 ,  A61L2400/06 ,  C08B37/0072

摘要： The present invention provides a method for preparing a water insoluble gel composition comprising: mixing a water soluble polysaccharide, an epoxy cross-linking agent, an alkaline compound and a solvent; and drying the thus obtained mixture at 1 to 30° C. under vacuum to remove the solvent, and a water insoluble gel composition.

摘要翻译： 本发明提供一种制备水不溶性凝胶组合物的方法，包括：将水溶性多糖，环氧交联剂，碱性化合物和溶剂混合; 并在1至30℃下真空干燥所得混合物以除去溶剂和水不溶性凝胶组合物。

公开(公告)号：US09493636B2

公开(公告)日：2016-11-15

申请号：US14359520

申请日：2012-11-21

申请人： Young Chang Ah ,  Sung Yeon Cho ,  In Seok Hwang ,  Sun Young Park ,  Hyun Ju Ko ,  Hyuk Kim ,  Min Jung Kwon ,  Won Seok Park

发明人： Young Chang Ah ,  Sung Yeon Cho ,  In Seok Hwang ,  Sun Young Park ,  Hyun Ju Ko ,  Hyuk Kim ,  Min Jung Kwon ,  Won Seok Park

IPC分类号： C08L5/08 ,  A61L27/20 ,  A61L15/28 ,  C08B37/08 ,  A61K9/06 ,  A61K47/36

CPC分类号： C08L5/08 ,  A61K9/06 ,  A61K47/36 ,  A61L15/28 ,  A61L27/20 ,  A61L2400/06 ,  C08B37/0072

摘要： The present invention provides a method for preparing a water insoluble gel composition comprising: mixing a water soluble polysaccharide, an epoxy cross-linking agent, an alkaline compound and a solvent; and drying the thus obtained mixture at 1 to 30° C. under vacuum to remove the solvent, and a water insoluble gel composition.

摘要翻译： 本发明提供一种制备水不溶性凝胶组合物的方法，包括：将水溶性多糖，环氧交联剂，碱性化合物和溶剂混合; 并在1至30℃下真空干燥所得混合物以除去溶剂和水不溶性凝胶组合物。

公开(公告)号：US08728514B2

公开(公告)日：2014-05-20

申请号：US12084014

申请日：2006-10-23

申请人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

发明人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

IPC分类号： A61K9/70

CPC分类号： A61K9/7061 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/196

摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.

摘要翻译： 公开了含有疏水性药物的透皮制剂。 作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低 即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。 在将透皮制剂施用于皮肤期间，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以保持使用期间的足够的粘附性和最小化皮肤的副作用。 亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴剂外部的疏水性粘合剂层来发挥功能。

公开(公告)号：US20090117192A1

公开(公告)日：2009-05-07

申请号：US12300213

申请日：2007-05-03

申请人： Young Chang Ah ,  Byoung Young Woo ,  Yang Gyu Choi ,  Han Moe Ki

发明人： Young Chang Ah ,  Byoung Young Woo ,  Yang Gyu Choi ,  Han Moe Ki

IPC分类号： A61K9/10 ,  A61K31/5415 ,  A61K31/60

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K9/7084

摘要： The inventive composition for transdermal absorption characterized by comprising a nonsteroidal anti-inflammatory drug as an active ingredient together with an alkali metal-containing alcohol derivative as a solubilizing agent for the active ingredient comprises a high concentration of the active ingredient while using only a small amount of the solvent, and a transdermal absorption formulation comprising a polymeric matrix formed from the composition is capable of maximizing the skin absorption of the active ingredient with minimal skin irritation.

摘要翻译： 用于透皮吸收的本发明组合物的特征在于包含非甾体抗炎药物作为活性成分以及含有碱金属的醇衍生物作为活性成分的增溶剂，其包含高浓度的活性成分，同时仅使用少量 的溶剂，并且包含由该组合物形成的聚合物基质的透皮吸收制剂能够以最小的皮肤刺激使活性成分的皮肤吸收最大化。

公开(公告)号：US20090252782A1

公开(公告)日：2009-10-08

申请号：US12084014

申请日：2006-10-23

申请人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

发明人： Yang Gyu Choi ,  Young Chang Ah ,  Woo Jeong Choi ,  Jung Ju Kim

IPC分类号： A61K9/70

CPC分类号： A61K9/7061 ,  A61K31/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/196

摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.

摘要翻译： 公开了含有疏水性药物的透皮制剂。 作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低 即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。 在将透皮制剂施用于皮肤期间，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以保持使用期间的足够的粘附性和最小化皮肤的副作用。 亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴剂外部的疏水性粘合剂层来发挥功能。