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1.发明申请COMPOSITION FOR TRANSDERMAL ABSORPTION AND FORMULATION COMPRISING A POLYMERIC MATRIX FORMED THEREFROM 审中-公开用于超吸收和组成包含其中形成的聚合物基质的组合物公开(公告)号：US20090117192A1
公开(公告)日：2009-05-07
申请号：US12300213
申请日：2007-05-03
申请人： Young Chang Ah , Byoung Young Woo , Yang Gyu Choi , Han Moe Ki
发明人： Young Chang Ah , Byoung Young Woo , Yang Gyu Choi , Han Moe Ki
IPC分类号： A61K9/10 , A61K31/5415 , A61K31/60
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7084
摘要： The inventive composition for transdermal absorption characterized by comprising a nonsteroidal anti-inflammatory drug as an active ingredient together with an alkali metal-containing alcohol derivative as a solubilizing agent for the active ingredient comprises a high concentration of the active ingredient while using only a small amount of the solvent, and a transdermal absorption formulation comprising a polymeric matrix formed from the composition is capable of maximizing the skin absorption of the active ingredient with minimal skin irritation.
摘要翻译： 用于透皮吸收的本发明组合物的特征在于包含非甾体抗炎药物作为活性成分以及含有碱金属的醇衍生物作为活性成分的增溶剂，其包含高浓度的活性成分，同时仅使用少量 的溶剂，并且包含由该组合物形成的聚合物基质的透皮吸收制剂能够以最小的皮肤刺激使活性成分的皮肤吸收最大化。
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2.发明申请NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 有权新型化合物，异构体或其药学上可接受的盐作为VANILLOID受体拮抗剂和含有其的药物组合物公开(公告)号：US20110152318A1
公开(公告)日：2011-06-23
申请号：US13002289
申请日：2009-07-02
申请人： Byoung Young Woo , Sun-Young Kim , Yeonjoon Kim , Song Seok Shin , Jin Kwan Kim , Ki-Wha Lee , Dong Hyun Kim , Kyung Min Lim , Joo-Hyun Moh , Yeon Su Jeong , Jin Kyu Choi , Hyun Ju Koh , Jeongho Lee , Hyuk Kim , Jeong Hoon Yoon , Funan Li , Jee-Suk Kim , Young-Ger Suh
发明人： Byoung Young Woo , Sun-Young Kim , Yeonjoon Kim , Song Seok Shin , Jin Kwan Kim , Ki-Wha Lee , Dong Hyun Kim , Kyung Min Lim , Joo-Hyun Moh , Yeon Su Jeong , Jin Kyu Choi , Hyun Ju Koh , Jeongho Lee , Hyuk Kim , Jeong Hoon Yoon , Funan Li , Jee-Suk Kim , Young-Ger Suh
IPC分类号： A61K31/421 , C07D263/48 , C07D277/56 , C07D413/04 , C07D333/38 , A61K31/426 , A61K31/4709 , A61K31/381 , A61K31/4439 , A61P29/00 , A61P25/00 , A61P25/28 , A61P13/00 , A61P1/00 , A61P1/04 , A61P11/14 , A61P11/06 , A61P17/04 , A61P17/06 , A61P17/00 , A61P9/10 , A61P17/14
CPC分类号： C07D263/42 , C07D263/34 , C07D263/38 , C07D263/48 , C07D277/42 , C07D277/56 , C07D307/52 , C07D307/68 , C07D333/38 , C07D413/04 , C07D413/12
摘要： This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.
摘要翻译： 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。
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3.发明授权Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same 有权化合物，其异构体或其药学上可接受的盐作为香草素受体拮抗剂和含有它们的药物组合物公开(公告)号：US08691855B2
公开(公告)日：2014-04-08
申请号：US13002289
申请日：2009-07-02
申请人： Byoung Young Woo , Sun-Young Kim , Yeonjoon Kim , Song Seok Shin , Jin Kwan Kim , Ki-Wha Lee , Dong Hyun Kim , Kyung Min Lim , Joo-Hyun Moh , Yeon Su Jeong , Jin Kyu Choi , Hyun Ju Koh , Jeongho Lee , Hyuk Kim , Jeong Hoon Yoon , Funan Li , Jee-Suk Kim , Young-Ger Suh
发明人： Byoung Young Woo , Sun-Young Kim , Yeonjoon Kim , Song Seok Shin , Jin Kwan Kim , Ki-Wha Lee , Dong Hyun Kim , Kyung Min Lim , Joo-Hyun Moh , Yeon Su Jeong , Jin Kyu Choi , Hyun Ju Koh , Jeongho Lee , Hyuk Kim , Jeong Hoon Yoon , Funan Li , Jee-Suk Kim , Young-Ger Suh
IPC分类号： C07D263/42 , C07D263/38 , C07D307/52 , C07D277/42
CPC分类号： C07D263/42 , C07D263/34 , C07D263/38 , C07D263/48 , C07D277/42 , C07D277/56 , C07D307/52 , C07D307/68 , C07D333/38 , C07D413/04 , C07D413/12
摘要： This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.
摘要翻译： 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。
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4.发明授权公开(公告)号：US08013187B2
公开(公告)日：2011-09-06
申请号：US11720081
申请日：2005-11-30
申请人： Yeonjoon Kim , Sun-Young Kim , Jung Sun Hwang , Kyoung Min Lim , Miyoung Park , Hyun Ju Koh , Sa-Yong Hong , Song Seok Shin , Jin Kyu Choi , Joo-Hyun Moh , Shin Chung , Byoung Young Woo , Sung Il Kim
发明人： Yeonjoon Kim , Sun-Young Kim , Jung Sun Hwang , Kyoung Min Lim , Miyoung Park , Hyun Ju Koh , Sa-Yong Hong , Song Seok Shin , Jin Kyu Choi , Joo-Hyun Moh , Shin Chung , Byoung Young Woo , Sung Il Kim
IPC分类号： C07C259/00 , C07D305/00 , C07D307/02 , C07D339/08 , A01N43/38 , A01N43/08 , A01N43/02
CPC分类号： C07C317/32 , C07C251/44 , C07C255/61 , C07C259/18 , C07C323/47 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D209/08 , C07D213/53 , C07D307/91 , C07D317/58 , C07D333/22 , C07D333/58 , C07D339/08
摘要： 2-cyclopenten-1-one oxime derivatives represented by Formula (I), or pharmaceutically acceptable salts thereof inhibit the production of TNF-α or PDE4, and therefore show therapeutic effect in inflammatory or immunological disorders mediated through TNF-α or PDE4.
摘要翻译： 由式（I）表示的2-环戊烯-1-酮肟衍生物或其药学上可接受的盐抑制TNF-α或PDE4的产生，因此在通过TNF-α或PDE4介导的炎性或免疫学障碍中显示出治疗效果。
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5.发明申请NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 有权新化合物，其异构体，或其药学上可接受的盐作为VANILLOID受体拮抗剂; 和含有它们的药物组合物公开(公告)号：US20090105258A1
公开(公告)日：2009-04-23
申请号：US11909136
申请日：2006-03-15
申请人： Hee-Doo Kim , Young-Ger Suh , Hyeung-Geun Park , Uh Taek Oh , Seol Rin Park , Joo Hyun Kim , Mi Jung Jang , Young-Ho Park , Song Seok Shin , Sun-Young Kim , Jin Kwan Kim , Yeon Su Jeong , Ki-Wha Lee , Jin Kyu Choi , Kyung Min Lim , Hyun Ju Koh , Joo Hyun Moh , Sung-II Kim , Byoung Young Woo
发明人： Hee-Doo Kim , Young-Ger Suh , Hyeung-Geun Park , Uh Taek Oh , Seol Rin Park , Joo Hyun Kim , Mi Jung Jang , Young-Ho Park , Song Seok Shin , Sun-Young Kim , Jin Kwan Kim , Yeon Su Jeong , Ki-Wha Lee , Jin Kyu Choi , Kyung Min Lim , Hyun Ju Koh , Joo Hyun Moh , Sung-II Kim , Byoung Young Woo
IPC分类号： A61K31/5375 , C07C275/24 , A61P1/02 , A61K31/18 , A61K31/165 , C07C233/40 , C07D295/145
CPC分类号： C07C275/24 , C07C311/08 , C07C311/11 , C07C323/62 , C07D211/46 , C07D295/088 , C07D295/155 , C07D309/12 , C07F7/081
摘要： This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salt thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.
摘要翻译： 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼睛或粘膜，胃十二指肠溃疡，炎症性疾病，耳疾病和心脏病。
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6.发明申请公开(公告)号：US20090036501A1
公开(公告)日：2009-02-05
申请号：US11720081
申请日：2005-11-30
申请人： Yeonjoon Kim , Sun-Young Kim , Jung Sun Hwang , Kyoung Min Lim , Miyoung Park , Hyun Ju Koh , Sa-yong Hong , Song Seok Shin , Jin Kyu Choi , Joo Hyun Moh , Chin Chung , Byoung Young Woo , Sung II Kim
发明人： Yeonjoon Kim , Sun-Young Kim , Jung Sun Hwang , Kyoung Min Lim , Miyoung Park , Hyun Ju Koh , Sa-yong Hong , Song Seok Shin , Jin Kyu Choi , Joo Hyun Moh , Chin Chung , Byoung Young Woo , Sung II Kim
IPC分类号： A61K31/44 , C07C249/04 , A61K31/15 , C07D209/04 , A61K31/404 , C07D307/91 , A61P37/02 , A61K31/343 , C07D339/08 , A61K31/385 , C07D213/02
CPC分类号： C07C317/32 , C07C251/44 , C07C255/61 , C07C259/18 , C07C323/47 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D209/08 , C07D213/53 , C07D307/91 , C07D317/58 , C07D333/22 , C07D333/58 , C07D339/08
摘要： 2-cyclopenten-1-one oxime derivatives represented by Formula (I), or pharmaceutically acceptable salts thereof inhibit the production of TNF-α or PDE4, and therefore show therapeutic effect in inflammatory or immunological disorders mediated through TNF-α or PDE4.
摘要翻译： 由式（I）表示的2-环戊烯-1-酮肟衍生物或其药学上可接受的盐抑制TNF-α或PDE4的产生，因此在通过TNF-α或PDE4介导的炎性或免疫学障碍中显示出治疗效果。
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7.发明授权Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same 有权化合物，其异构体或其药学上可接受的盐作为香草素受体拮抗剂; 和含有它们的药物组合物公开(公告)号：US08557872B2
公开(公告)日：2013-10-15
申请号：US12865082
申请日：2009-01-28
申请人： Song Seok Shin , Jin Kwan Kim , Sun-Young Kim , Ki-Wha Lee , Byoung Young Woo , Joo-Hyun Moh , Yeon Su Jeong , Kyung Min Lim , Jin Kyu Choi , Hyun-Ju Koh , Young-Ho Park
发明人： Song Seok Shin , Jin Kwan Kim , Sun-Young Kim , Ki-Wha Lee , Byoung Young Woo , Joo-Hyun Moh , Yeon Su Jeong , Kyung Min Lim , Jin Kyu Choi , Hyun-Ju Koh , Young-Ho Park
IPC分类号： A01N37/18 , A01N41/06 , A61K31/165 , A61K31/18 , C07C233/00 , C07C235/00 , C07C237/00 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC分类号： C07C311/08 , C07C2601/14 , C07D295/145
摘要： This present disclosure relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same.The present disclosure provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.
摘要翻译： 本公开涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanilloid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本公开提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。
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8.发明授权Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same 有权化合物，其异构体或其药学上可接受的盐作为香草素受体拮抗剂; 和含有它们的药物组合物公开(公告)号：US07858621B2
公开(公告)日：2010-12-28
申请号：US11829531
申请日：2007-07-27
申请人： Sun-Young Kim , Jin Kwan Kim , Ki-Wha Lee , Byoung Young Woo , Song Seok Shin , Joo-Hyun Moh , Sung-Il Kim , Yeon Su Jeong , Kyung Min Lim , Jin Kyu Choi , Jun Yong Ha , Hyun-Ju Koh , Young-Ho Park , Young-Ger Suh , Hee-Doo Kim , Hyeung-Geun Park , Uh Taek Oh
发明人： Sun-Young Kim , Jin Kwan Kim , Ki-Wha Lee , Byoung Young Woo , Song Seok Shin , Joo-Hyun Moh , Sung-Il Kim , Yeon Su Jeong , Kyung Min Lim , Jin Kyu Choi , Jun Yong Ha , Hyun-Ju Koh , Young-Ho Park , Young-Ger Suh , Hee-Doo Kim , Hyeung-Geun Park , Uh Taek Oh
IPC分类号： C07D401/04 , C07D213/56 , A61K31/44
CPC分类号： C07D213/74 , C07C311/08 , C07D213/56 , C07D213/61 , C07D213/64 , C07D295/155
摘要： This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same.The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.
摘要翻译： 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼或粘膜，胃十二指肠溃疡，炎性疾病，耳病，心脏病等。
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9.发明授权Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same 有权化合物，其异构体或其药学上可接受的盐作为香草素受体拮抗剂; 和含有它们的药物组合物公开(公告)号：US07763657B2
公开(公告)日：2010-07-27
申请号：US11909136
申请日：2006-03-15
申请人： Hee-Doo Kim , Young-Ger Suh , Hyeung-Geun Park , Uh Taek Oh , Seol Rin Park , Joo Hyun Kim , Mi Jung Jang , Young-Ho Park , Song Seok Shin , Sun-Young Kim , Jin Kwan Kim , Yeon Su Jeong , Ki-Wha Lee , Jin Kyu Choi , Kyung Min Lim , Hyun Ju Koh , Joo Hyun Moh , Sung-Il Kim , Byoung Young Woo
发明人： Hee-Doo Kim , Young-Ger Suh , Hyeung-Geun Park , Uh Taek Oh , Seol Rin Park , Joo Hyun Kim , Mi Jung Jang , Young-Ho Park , Song Seok Shin , Sun-Young Kim , Jin Kwan Kim , Yeon Su Jeong , Ki-Wha Lee , Jin Kyu Choi , Kyung Min Lim , Hyun Ju Koh , Joo Hyun Moh , Sung-Il Kim , Byoung Young Woo
IPC分类号： A61K31/17 , A61K31/18 , A61K31/351 , A61K31/4453 , A61K31/45 , A61K31/445 , A61K31/495 , A61K31/5375 , C07D241/04 , C07D265/30 , C07D211/06 , C07D211/46 , C07D315/00 , C07C311/08 , C07C275/24
CPC分类号： C07C275/24 , C07C311/08 , C07C311/11 , C07C323/62 , C07D211/46 , C07D295/088 , C07D295/155 , C07D309/12 , C07F7/081
摘要： This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salt thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.
摘要翻译： 本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanillaid Receptor 1; VR1; TRRPV1）拮抗剂; 和含有该组合物的药物组合物。 本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激， 眼睛或粘膜，胃十二指肠溃疡，炎症性疾病，耳疾病和心脏病。
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