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1.发明申请公开(公告)号：US20070274907A1
公开(公告)日：2007-11-29
申请号：US10593045
申请日：2004-05-12
申请人： Yuhua Li , Caryn Peterson , Scott Rudge , Suzanne Stevens , Gilles Tapolsky
发明人： Yuhua Li , Caryn Peterson , Scott Rudge , Suzanne Stevens , Gilles Tapolsky
IPC分类号： A61K51/00 , A61K49/10 , A61K9/14 , A61K31/407
CPC分类号： A61K9/1611 , A61K9/0019 , A61K9/5094
摘要： The present embodiments are directed to compositions and methods of delivering the compositions that comprise mitomycin C and superior magnetically targetable carrier particles. As the compositions are magnetically targetable, their use allows the localization of mitomycin C to particular locations within a patient. This allows for an increase in the effective concentration or a decrease in systemic exposure of mitomycin C in a patient.
摘要翻译： 本实施方案涉及递送包含丝裂霉素C和优异的可磁性靶向载体颗粒的组合物的组合物和方法。 由于组合物是可磁性靶向的，它们的用途允许将丝裂霉素C定位在患者体内的特定位置。 这可以增加患者中丝裂霉素C的有效浓度或全身暴露的减少。
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公开(公告)号：US07090636B2
公开(公告)日：2006-08-15
申请号：US10734651
申请日：2003-12-12
IPC分类号： A61N2/00
CPC分类号： A61K9/5094
摘要： A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field that, in one embodiment, may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet keeper-shield assembly includes a magnetically permeable keeper-shield with a bore dimensioned to hold the magnet. A lever mechanism is used to push the magnet partially out of the keeper-shield. The actuator is assisted by several springs extending through the base of the keeper-shield.
摘要翻译： 磁体保持器 - 屏蔽组合件，其适于保持和存储用于产生高梯度磁场的永磁体，在一个实施例中，该永久磁体可以穿透到深的靶向肿瘤部位以便吸引响应敏感的微载体。 磁力保持器 - 屏蔽组件包括具有用于保持磁体的孔尺寸的导磁保持器屏蔽件。 杠杆机构用于将磁体部分地推出保护罩。 致动器由几个延伸穿过保护罩底部的弹簧辅助。
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公开(公告)号：US06488615B1
公开(公告)日：2002-12-03
申请号：US09538952
申请日：2000-03-31
IPC分类号： A61N200
CPC分类号： A61N2/06 , A61K9/5094 , A61N1/406 , A61N2/004
摘要： A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field. Such a field may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet keeper-shield assembly includes a magnetically permeable keeper-shield with a bore dimensioned to hold the magnet. A screw driven actuator is used to push the magnet partially out of the keeper-shield. The actuator is assisted by several springs extending through the base of the keeper-shield.
摘要翻译： 一种适于保持和存储用于产生高梯度磁场的永磁体的磁力保持器 - 屏蔽组件。 这样的一个领域可能会渗透到深入靶点的肿瘤部位，以便吸引响应敏感的微载体。 磁力保持器 - 屏蔽组件包括具有用于保持磁体的孔尺寸的导磁保持器屏蔽件。 螺丝驱动的致动器用于将磁体部分地推出保持器屏蔽。 致动器由几个延伸穿过保护罩底部的弹簧辅助。
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公开(公告)号：US20140072613A1
公开(公告)日：2014-03-13
申请号：US13829876
申请日：2013-03-14
申请人： Cynthia Lander , Caryn Peterson , Colleen Brophy
发明人： Cynthia Lander , Caryn Peterson , Colleen Brophy
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K9/0014 , A61K9/0019 , A61K9/08 , A61K38/55 , A61K45/06 , B33Y80/00 , A61K2300/00
摘要： The described invention provides compositions, dressings and methods for treating a cutaneous scar in a subject. The compositions of the derived invention contains a pharmaceutical composition comprising a therapeutic amount of a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) inhibitor comprising an MK2 polypeptide inhibitor or a functional equivalent thereof, and a pharmaceutically acceptable carrier.
摘要翻译： 所述发明提供了用于治疗受试者皮肤瘢痕的组合物，敷料和方法。 衍生发明的组合物含有包含治疗量的包含MK2多肽抑制剂或其功能等同物的丝裂原活化蛋白激酶活化蛋白激酶2（MK2）抑制剂和药学上可接受的载体的药物组合物。
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公开(公告)号：US06663555B2
公开(公告)日：2003-12-16
申请号：US10087442
申请日：2002-03-01
IPC分类号： A61N200
CPC分类号： A61N2/06 , A61K9/5094 , A61N1/406 , A61N2/004
摘要： A magnet keeper-shield assembly adapted to hold and store a permanent magnet used to generate a high gradient magnetic field. Such a field may penetrate into deep targeted tumor sites in order to attract magnetically responsive micro-carriers. The magnet keeper-shield assembly includes a magnetically permeable keeper-shield with a bore dimensioned to hold the magnet. A screw driven actuator is used to push the magnet partially out of the keeper-shield. The actuator is assisted by several springs extending through the base of the keeper-shield.
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