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公开(公告)号：US20130209660A1
公开(公告)日：2013-08-15
申请号：US13882056
申请日：2011-10-27
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0053 , B05D1/18 , B05D1/28
摘要： Since all methods of applying a drug liquid to a tip portion of a microneedle are application of the drug liquid in an open system, evaporation of the solvent from the drug liquid is unavoidable, such that the concentration of the drug liquid changes easily, and a large amount of the drug liquid is necessary. The invention provides a method of applying a drug to a pin-frog-shaped microneedle by using a small amount of the solution and without variation of the concentration of the drug liquid. A member having plural grooves is produced, and one end thereof is immersed in a drug liquid tank to fill the grooves with the drug liquid. The drug can be uniformly applied to a tip portion of the microneedle by setting the pin-frog-shaped microneedle to pass through the drug liquid in the grooves.
摘要翻译： 由于将药液施加到微针的尖端部分的所有方法都是在开放系统中施用药液，所以溶剂从药液的蒸发是不可避免的，使得药物液体的浓度容易变化，并且 大量的药液是必需的。 本发明提供了通过使用少量的溶液并且不改变药液浓度的方式将药物施用于针状青蛙形微针。 制造具有多个凹槽的构件，并且其一端浸入药液罐中以用药液填充凹槽。 通过将销青蛙形的微针设置成通过槽内的药液，可以将药物均匀地施加到微针的前端部。
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2.发明授权Medication liquid supporting jig and method of applying medication to micro-needle using same 有权药物液体支持夹具及使用其的微针施用药物的方法公开(公告)号：US09067048B2
公开(公告)日：2015-06-30
申请号：US13265997
申请日：2010-04-24
申请人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto
发明人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0053
摘要： Provided are a jig for uniformly applying a drug liquid to a microneedle, and a method of applying a drug to a microneedle using same. Grooves of a number corresponding to the number of rows of small needles of a microneedle are formed in the surface of a flat plate jig or of a roller-like jig, and a drug liquid is filled and held in the grooves. The drug liquid is applied to the microneedle by inserting the small needles of the microneedle into the surface of the drug liquid held in the narrow grooves, and immersing the small needles in the drug liquid. By this, the drug liquid is uniformly applied to the small needles of the microneedle without unevenness between the central section and the peripheral section of each microneedle, and thus the microneedles having good quality can be easily manufactured.
摘要翻译： 提供了用于将药液均匀地施加到微针的夹具，以及使用其将药物施加到微针的方法。 在平板夹具或辊状夹具的表面上形成与微针的小针数相对应的数字的槽，并且将药液填充并保持在槽中。 通过将微针的小针插入保持在窄槽中的药液的表面，并将小针浸入药液中，将药液施加到微针上。 由此，将药液均匀地施加到微针的小针上，而在每个微针的中心部和周边部之间没有不均匀，因此可以容易地制造质量好的微针。
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3.发明申请公开(公告)号：US20120080119A1
公开(公告)日：2012-04-05
申请号：US13265997
申请日：2010-04-24
申请人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto
发明人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0053
摘要： Provided are a jig for uniformly applying a drug liquid to a microneedle, and a method of applying a drug to a microneedle using same. Grooves of a number corresponding to the number of rows of small needles of a microneedle are formed in the surface of a flat plate jig or of a roller-like jig, and a drug liquid is filled and held in the grooves. The drug liquid is applied to the microneedle by inserting the small needles of the microneedle into the surface of the drug liquid held in the narrow grooves, and immersing the small needles in the drug liquid. By this, the drug liquid is uniformly applied to the small needles of the microneedle without unevenness between the central section and the peripheral section of each microneedle, and thus the microneedles having good quality can be easily manufactured.
摘要翻译： 提供了用于将药液均匀地施加到微针的夹具，以及使用其将药物施加到微针的方法。 在平板夹具或辊状夹具的表面上形成与微针的小针数相对应的数字的槽，并且将药液填充并保持在槽中。 通过将微针的小针插入保持在窄槽中的药液的表面，并将小针浸入药液中，将药液施加到微针上。 由此，将药液均匀地施加到微针的小针上，而在每个微针的中心部和周边部之间没有不均匀，因此可以容易地制造质量好的微针。
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公开(公告)号：US20100036002A1
公开(公告)日：2010-02-11
申请号：US12520678
申请日：2007-12-25
CPC分类号： A61K47/30 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/795
摘要： The invention provides a porous dry matrix preparation comprising at least a polymeric thickener and an excipient ingredient, wherein (1) the content of the polymeric thickener is down to 0.5 w/w % and up to 14 w/w %, (2) the content of the excipient ingredient is down to 30 w/w % and up to 80 w/w %, (3) the void ratio is not less than 20%, and (4) the water activity is not more than 0.55, or water content is not more than 10 w/w %.
摘要翻译： 本发明提供一种包含至少一种聚合物增稠剂和赋形剂成分的多孔干燥基质制剂，其中（1）聚合物增稠剂的含量低至0.5w / w％且至多14w / w％，（2） 赋形剂成分含量低至30w / w％至80w / w％，（3）空隙率不小于20％，（4）水分活度不大于0.55，或水 含量不超过10w / w％。
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公开(公告)号：US09750924B2
公开(公告)日：2017-09-05
申请号：US13574496
申请日：2011-01-20
CPC分类号： A61M37/0015 , A61M2025/0253 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： The invention provides an applicator that holds a microneedle to facilitate puncture of the skin and includes an assisting tool as a supporting base to set the microneedle and an adhesive sheet such as a tape and the like, on the side face of the assisting tool to enable close adhesion of the microneedle puncturing the skin.
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公开(公告)号：US09636490B2
公开(公告)日：2017-05-02
申请号：US13881322
申请日：2011-10-24
申请人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
发明人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061
摘要： A microneedle and a microneedle array, which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, includes a frustum and a forward end portion thereon, the forward end portion having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 μm and satisfying the expression H/D≧5, where H is a total height of the microneedle, and D is a diameter of a bottom surface of the frustum).
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公开(公告)号：US20120184916A1
公开(公告)日：2012-07-19
申请号：US13389402
申请日：2010-08-04
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2025/0266 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046
摘要： Provided is a microneedle device which protects a microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture to administer a drug. By studying the relationship between the device to be pressed to the skin and the height of the elevation of the skin surface during the pressing, it is found that there is a positive correlation between the placement and interval of skin fixing members and the height of the elevation of the skin. It is furthermore found that the elevated skin surface is always parallel to the flat plate of the device. This reveals that since the microneedle installed in the device can be inserted at right angle to the skin surface, the skin can reliably be punctuated avoiding the breakage etc. of the small needles of the microneedle. Thus, a microneedle patch which is easily portable and ensures convenient drug administration to the skin can be produced.
摘要翻译： 提供一种微针装置，其保护微针，具有容易携带的形状，在使用微针刺穿皮肤的步骤中没有诸如破裂小针的问题，并且确保适当的皮肤穿刺以施用药物。 通过研究压制装置与皮肤表面高度之间的关系，发现皮肤固定部件的位置和间隔与皮肤固定部件的高度之间存在正相关 皮肤的高度。 此外，还发现升高的皮肤表面总是平行于装置的平板。 这表明，由于安装在装置中的微针可以与皮肤表面成直角插入，所以可以可靠地标记皮肤，避免微针的小针断裂等。 因此，可以制造容易携带并确保方便的向皮肤给药的微针补片。
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公开(公告)号：US20120029434A1
公开(公告)日：2012-02-02
申请号：US13202931
申请日：2010-02-19
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M5/425 , A61M2037/0023
摘要： Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship between a device to be pressed to the skin and the height of an elevation on the skin surface under the pressing and thus producing a device equipped with microneedle that are embedded in a concave part having a definite depth, the microneedle can be surely and easily inserted and punctured into the skin while avoiding such problems as breakage of the small needles of the microneedle. Thus, a microneedle patch formulation, which is easily portable and ensures convenient drug administration to the skin, can be produced.
摘要翻译： 本发明提供一种微针装置，其保护微针，具有便于携带的形状，在使用微针刺穿皮肤的步骤中没有小针断裂等问题，并且确保适当的皮肤穿刺用于给药。 通过研究被压制的装置与被压制在皮肤表面上的高度之间的关系，从而制造装配有微针的装置，其嵌入具有一定深度的凹部中，微针可以是 确保和容易地插入并穿刺入皮肤，同时避免了微针的小针断裂等问题。 因此，可以制造容易携带并确保方便的皮肤给药的微针贴剂制剂。
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公开(公告)号：US20130296790A1
公开(公告)日：2013-11-07
申请号：US13881322
申请日：2011-10-24
申请人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
发明人： Koichi Masaoka , Keizo Ikari , Takashi Oda , Katsunori Kobayashi , Hidetoshi Hamamoto , Masaki Ishibashi , Kiyotsuna Toyohara
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0053 , A61M2037/0061
摘要： Provided are a microneedle and a microneedle array which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, the microneedle comprising a frustum and a forward end portion thereon, having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 μm and satisfying the following expression (1), H/D≧5 (1) (H: Height of the whole, D: Diameter of bottom surface of the frustum).
摘要翻译： 提供了一种微针和微针阵列，其具有安全性和易于使用的两个方面，并且可以通过平滑地进入患者的皮肤表面层而施加预定剂量的药剂而不引起疼痛，所述微针包括截头锥体和 其前端部具有15-60°的前端顶角和1〜20μm的前端直径，满足下式（1）：H / D> = 5（1 ）（H：整体高度，D：截头锥体底面的直径）。
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公开(公告)号：US08579862B2
公开(公告)日：2013-11-12
申请号：US13202931
申请日：2010-02-19
CPC分类号： A61M37/0015 , A61M5/425 , A61M2037/0023
摘要： Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship between a device to be pressed to the skin and the height of an elevation on the skin surface under the pressing and thus producing a device equipped with microneedle that are embedded in a concave part having a definite depth, the microneedle can be surely and easily inserted and punctured into the skin while avoiding such problems as breakage of the small needles of the microneedle. Thus, a microneedle patch formulation, which is easily portable and ensures convenient drug administration to the skin, can be produced.
摘要翻译： 本发明提供一种微针装置，其保护微针，具有便于携带的形状，在使用微针刺穿皮肤的步骤中没有小针断裂等问题，并且确保适当的皮肤穿刺用于给药。 通过研究被压制的装置与被压制在皮肤表面上的高度之间的关系，从而制造装配有微针的装置，其嵌入具有一定深度的凹部中，微针可以是 确保和容易地插入并穿刺入皮肤，同时避免了微针的小针断裂等问题。 因此，可以制造容易携带并确保方便的皮肤给药的微针贴剂制剂。
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