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公开(公告)号：US08207131B2
公开(公告)日：2012-06-26
申请号：US12298190
申请日：2007-04-25
申请人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroaki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroaki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
CPC分类号： C07K5/1024 , A21D2/26 , A21D2/268 , A23C9/1544 , A23C19/082 , A23C19/086 , A23K20/147 , A23K50/40 , A23L2/02 , A23L2/52 , A23L33/18 , A61K38/00 , C07K7/06
摘要： The present invention relates to a peptide that is derived from a milk protein and has an antioxidative effect, an antioxidant that includes the peptide as an active ingredient, and an antioxidative food, drink, or feed that includes the peptide. The present invention also relates to a peptide that is derived from a milk protein and has an adiponectin production promotion effect, an adiponectin production promoter that includes the peptide as an active ingredient, and an adiponectin production promotion food, drink, or feed that includes the peptide. The present invention further relates to a blood adiponectin level increase promotion and/or decrease inhibition agent that includes a component contained in cheese as an active ingredient, and a blood adiponectin level increase promotion and/or decrease inhibition food or drink that includes a component contained in cheese. The present invention to the peptide that consists of an amino acid sequence shown by His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln (1), His-Pro-Ile-Lys (2) or His-Gln-Gly-Leu-Pro-Gln (3), and has an antioxidative effect.
摘要翻译： 本发明涉及一种衍生自乳蛋白并具有抗氧化作用的肽，包含该肽作为活性成分的抗氧化剂和包含该肽的抗氧化食品，饮料或饲料。 本发明还涉及一种衍生自乳蛋白质并具有脂联素生产促进作用的肽，包含该肽作为活性成分的脂联素生产促进剂，以及含有所述脂联素生产促进食品，饮料或饲料 肽。 本发明还涉及包含酪乳中含有的成分作为活性成分的血液脂联素含量增加促进和/或减少抑制剂，并且血液脂联素水平升高促进和/或减少抑制食品或饮料，其包含含有 在奶酪里 本发明涉及由His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln（1），His-Pro-Ile-Lys（2）或His -Gln-Gly-Leu-Pro-Gln（3），具有抗氧化作用。
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公开(公告)号：US20100075909A1
公开(公告)日：2010-03-25
申请号：US12298190
申请日：2007-04-25
申请人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yukiko Kunieda , Satoshi Higurashi , Mutsumi Motouri , Hiroki Matsuyama , Atsushi Serizawa , Hiroshi Kawakami
CPC分类号： C07K5/1024 , A21D2/26 , A21D2/268 , A23C9/1544 , A23C19/082 , A23C19/086 , A23K20/147 , A23K50/40 , A23L2/02 , A23L2/52 , A23L33/18 , A61K38/00 , C07K7/06
摘要： The present invention relates to a peptide that is derived from a milk protein and has an antioxidative effect, an antioxidant that includes the peptide as an active ingredient, and an antioxidative food, drink, or feed that includes the peptide. The present invention also relates to a peptide that is derived from a milk protein and has an adiponectin production promotion effect, an adiponectin production promoter that includes the peptide as an active ingredient, and an adiponectin production promotion food, drink, or feed that includes the peptide. The present invention further relates to a blood adiponectin level increase promotion and/or decrease inhibition agent that includes a component contained in cheese as an active ingredient, and a blood adiponectin level increase promotion and/or decrease inhibition food or drink that includes a component contained in cheese. The present invention to the peptide that consists of an amino acid sequence shown by His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln (1), His-Pro-Ile-Lys (2) or His-Gln-Gly-Leu-Pro-Gln (3), and has an antioxidative effect.
摘要翻译： 本发明涉及一种衍生自乳蛋白并具有抗氧化作用的肽，包含该肽作为活性成分的抗氧化剂和包含该肽的抗氧化食品，饮料或饲料。 本发明还涉及一种衍生自乳蛋白质并具有脂联素生产促进作用的肽，包含该肽作为活性成分的脂联素生产促进剂，以及包含该蛋白质的脂联素生产促进食品，饮料或饲料 肽。 本发明还涉及包含酪乳中含有的成分作为活性成分的血液脂联素含量增加促进和/或减少抑制剂，并且血液脂联素水平升高促进和/或减少抑制食品或饮料，其包含含有 在奶酪里 本发明涉及由His-Pro-Ile-Lys-His-Gln-Gly-Leu-Pro-Gln（1），His-Pro-Ile-Lys（2）或His -Gln-Gly-Leu-Pro-Gln（3），具有抗氧化作用。
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公开(公告)号：US20060228345A1
公开(公告)日：2006-10-12
申请号：US10566711
申请日：2004-08-13
CPC分类号： C12Y111/01007 , A23K20/189 , A23L33/19 , A23V2002/00 , A61K38/44 , A23V2250/5425 , A23V2200/306
摘要： It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.
摘要翻译： 旨在通过促进成骨细胞和用于促进成骨的食物，饮料，药物或饲料的分化来提供能够促进成骨的骨形成促进剂。 即，通过促进成骨细胞的分化来促进成骨的成骨促进剂，其包含作为活性成分的乳过氧化物酶和/或通过用蛋白酶如胰蛋白酶消化乳过氧化物酶获得的消化产物; 以及用于促进含有过氧化物酶和/或其消化产物的成骨的食物，饮料，药物或饲料。
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4.发明申请公开(公告)号：US20080206226A1
公开(公告)日：2008-08-28
申请号：US12102552
申请日：2008-04-14
CPC分类号： A61K38/1729 , A23K20/147 , A23K20/189 , A23L33/17 , A61K38/1725
摘要： Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
摘要翻译： 本发明提供一种用于促进成骨和/或抑制骨吸收的新型药剂，其可以直接从日常饮食中口服长时间，没有任何麻烦的味道; 直接对骨骼发生促进作用，对骨吸收骨骼具有抑制作用; 并且可以预期具有预防或改善/治疗各种骨疾病的治疗效果。 作为活性成分，上述试剂包含β2 - 亚微球蛋白，组蛋白，补体成分3，单核细胞趋化蛋白1，溶菌酶，核糖核酸酶，凝血酶原，细胞色素P-450，纤溶酶原中的任何一种或多种 ，转铁蛋白，凝血酶，纤溶酶，补体成分4和β防御素及其酶消化产物。 这些物质通过促进成骨细胞的增殖和分化对破骨细胞的骨吸收和/或对成骨的促进作用具有显着的抑制作用。
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公开(公告)号：US20060286084A1
公开(公告)日：2006-12-21
申请号：US10573776
申请日：2004-09-30
CPC分类号： A61K38/1729 , A23K20/147 , A23K20/189 , A23L33/17 , A61K38/1725
摘要： Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
摘要翻译： 本发明提供一种用于促进成骨和/或抑制骨吸收的新型药剂，其可以直接从日常饮食中口服长时间，没有任何麻烦的味道; 直接对骨骼发生促进作用，对骨吸收骨骼具有抑制作用; 并且可以预期具有预防或改善/治疗各种骨疾病的治疗效果。 作为活性成分，上述试剂包含β2 - 亚微球蛋白，组蛋白，补体成分3，单核细胞趋化蛋白1，溶菌酶，核糖核酸酶，凝血酶原，细胞色素P-450，纤溶酶原中的任何一种或多种 ，转铁蛋白，凝血酶，纤溶酶，补体成分4和β防御素及其酶消化产物。 这些物质通过促进成骨细胞的增殖和分化对破骨细胞的骨吸收和/或对成骨的促进作用具有显着的抑制作用。
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公开(公告)号：US08647619B2
公开(公告)日：2014-02-11
申请号：US12573413
申请日：2009-10-05
IPC分类号： A61K38/43
CPC分类号： C12Y111/01007 , A23K20/189 , A23K50/10 , A23K50/40 , A23L33/19 , A23V2002/00 , A61K38/44 , A23V2250/5425 , A23V2200/306
摘要： It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.
摘要翻译： 旨在通过促进成骨细胞和用于促进成骨的食物，饮料，药物或饲料的分化来提供能够促进成骨的骨形成促进剂。 即，通过促进成骨细胞的分化来促进成骨的成骨促进剂，其包含作为活性成分的乳过氧化物酶和/或通过用蛋白酶如胰蛋白酶消化乳过氧化物酶获得的消化产物; 以及用于促进含有过氧化物酶和/或其消化产物的成骨的食物，饮料，药物或饲料。
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