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公开(公告)号：US20050165114A1
公开(公告)日：2005-07-28
申请号：US11087531
申请日：2005-03-24
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07D207/16 , C07D209/48 , C07D209/76 , C07D213/81 , C07D491/18 , A61K31/165
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂 用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。
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公开(公告)号：US06563002B2
公开(公告)日：2003-05-13
申请号：US10085073
申请日：2002-03-01
IPC分类号： C07C23357
CPC分类号： C07D213/75 , C07C233/60 , C07C233/62 , C07C317/22 , C07C2601/02
摘要： The present invention discloses biscyclopropanecarboxamide compounds and pharmaceutically acceptable salts thereof; and also NF-kappa B activation inhibitors, Inflammatory cytokine production inhibitors, matrix metalloprotease production inhibitors, inflammatory cell adhesion molecules incidence inhibitors, antiinflammatory agents, antirheumatic agents, immunosuppressive agents, cancerous metastasis inhibitors or antiviral agents each containing such a compound as the active ingredient.
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公开(公告)号：US06703379B2
公开(公告)日：2004-03-09
申请号：US09803107
申请日：2001-03-12
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C23360
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂 用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。
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公开(公告)号：US07459585B2
公开(公告)日：2008-12-02
申请号：US11087531
申请日：2005-03-24
申请人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
发明人： Yukio Iino , Kohichi Fujita , Takashi Tsuji , Ariko Kodaira , Kenji Takehana , Tsuyoshi Kobayashi , Takashi Yamamoto
IPC分类号： C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C309/66 , C07C311/21 , C07D209/38 , C07D209/48 , C07D211/78
CPC分类号： C07D209/48 , C07B2200/05 , C07B2200/07 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/38 , C07C235/56 , C07C237/20 , C07C237/42 , C07C247/10 , C07C251/48 , C07C255/44 , C07C309/66 , C07C311/46 , C07C317/40 , C07C323/40 , C07C2601/02 , C07D207/16 , C07D209/76 , C07D213/81
摘要： The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶产生抑制剂，炎症细胞粘附分子表达抑制剂，抗炎剂，抗风湿剂，免疫抑制剂，癌症转移抑制剂 用于含有下列通式（I）的苯衍生物或其药学上可接受的盐作为活性成分的动脉硬化和抗病毒剂。
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公开(公告)号：US06794378B2
公开(公告)日：2004-09-21
申请号：US10029871
申请日：2001-12-31
申请人： Yukio Iino , Koichi Fujita , Ariko Kodaira , Toshihiro Hatanaka , Kenji Takehana , Tsuyoshi Kobayashi , Atsushi Konishi , Takashi Yamamoto
发明人： Yukio Iino , Koichi Fujita , Ariko Kodaira , Toshihiro Hatanaka , Kenji Takehana , Tsuyoshi Kobayashi , Atsushi Konishi , Takashi Yamamoto
IPC分类号： A61K3133
CPC分类号： C07D213/75 , C07D211/58 , C07D237/22 , C07D239/48 , C07D277/46
摘要： The present invention provides an AP-1 activation inhibitor, a NF-kappaB activation inhibitor, an inflammatory cytokine production inhibitor, a production inhibitor for matrix metalloprotease or an inflammatory cell adhesion factor expression inhibitor, which contains a heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译： 本发明提供了含有杂环化合物或其药学上可接受的盐的AP-1活化抑制剂，NF-κB活化抑制剂，炎性细胞因子产生抑制剂，基质金属蛋白酶的产生抑制剂或炎症细胞粘附因子表达抑制剂 作为活性成分。
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公开(公告)号：US07632830B2
公开(公告)日：2009-12-15
申请号：US11948288
申请日：2007-11-30
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , C07D498/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US20080096862A1
公开(公告)日：2008-04-24
申请号：US11948288
申请日：2007-11-30
申请人： Yukio IINO , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio IINO , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P3/00 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US07153850B2
公开(公告)日：2006-12-26
申请号：US10449774
申请日：2003-06-02
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , C07D498/04 , C07D513/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
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公开(公告)号：US07326701B2
公开(公告)日：2008-02-05
申请号：US11398675
申请日：2006-04-06
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US10239106B2
公开(公告)日：2019-03-26
申请号：US14781151
申请日：2014-04-01
摘要： A spinning method includes supporting a supported portion of a cylindrical work by a work supporting portion; pressing a first roller of a spinning head against a processed portion of the work while revolving the first roller; and performing a forming process that points a tube axis of the processed portion of the work in a given direction by pressing the first roller and a second roller in which a plane of revolution thereof is provided in a different position, in a rotational axis direction of a spindle of the spinning head, than a plane of revolution of the first roller, while revolving the first roller and the second roller, and moving the work supporting portion relative to the spinning head or moving the spinning head relative to the work supporting portion, while the first roller and the second roller work in cooperation with each other to retain the work.
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