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1.发明授权Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof 有权具有杂环的稠合多环化合物及其药物用途公开(公告)号：US08299064B2
公开(公告)日：2012-10-30
申请号：US13040882
申请日：2011-03-04
申请人： Ryusuke Hirama , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
发明人： Ryusuke Hirama , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
IPC分类号： A61P3/10 , A61P3/04 , A61P9/00 , A61P13/12 , A61P25/02 , A61P27/02 , A61K31/5517 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R′ represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R″ represent a hydrogen atom.
摘要翻译： 本发明提供下式的稠合多环化合物，其类似物和其药学上可接受的盐; 以及增加糖输送能力的药剂，含有上述化合物的降血糖药和药物组合物。 该稠合多环化合物具有很高的药用性质，副作用少，对糖尿病具有治疗作用。 其中R表示烷氧基，R'表示恶唑基丙酰基或噻唑基丙酰基，R“表示氢原子。
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2.发明申请NEW FUSED POLYCYCLIC COMPOUNDS HAVING A HETEROCYCLIC RING(S) AND PHARMACEUTICAL USE THEREOF 有权具有环状环的新型多环化合物及其药物用途公开(公告)号：US20110160191A1
公开(公告)日：2011-06-30
申请号：US13040882
申请日：2011-03-04
申请人： Ryusuke HIRAMA , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
发明人： Ryusuke HIRAMA , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
IPC分类号： A61K31/551 , C07D487/04 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R′ represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R″ represent a hydrogen atom.
摘要翻译： 本发明提供下式的稠合多环化合物，其类似物和其药学上可接受的盐; 以及增加糖输送能力的药剂，含有上述化合物的降血糖药和药物组合物。 该稠合多环化合物具有很高的药用性质，副作用少，对糖尿病具有治疗作用。 其中R表示烷氧基，R'表示恶唑基丙酰基或噻唑基丙酰基，R“表示氢原子。
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3.发明授权Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof 有权具有杂环的稠合多环化合物及其药物用途公开(公告)号：US07928101B2
公开(公告)日：2011-04-19
申请号：US11414499
申请日：2006-05-01
申请人： Ryusuke Hirama , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
发明人： Ryusuke Hirama , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
IPC分类号： A61P3/10 , A61K31/407 , A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R′ represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R″ represent a hydrogen atom.
摘要翻译： 本发明提供下式的稠合多环化合物，其类似物和其药学上可接受的盐; 以及增加糖输送能力的药剂，含有上述化合物的降血糖药和药物组合物。 该稠合多环化合物具有很高的药用性质，副作用少，对糖尿病具有治疗作用。 其中R表示烷氧基，R'表示恶唑基丙酰基或噻唑基丙酰基，R“表示氢原子。
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公开(公告)号：US07632830B2
公开(公告)日：2009-12-15
申请号：US11948288
申请日：2007-11-30
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , C07D498/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US20080096862A1
公开(公告)日：2008-04-24
申请号：US11948288
申请日：2007-11-30
申请人： Yukio IINO , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio IINO , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P3/00 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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公开(公告)号：US20060258637A1
公开(公告)日：2006-11-16
申请号：US11486213
申请日：2006-07-14
申请人： Ryusuke Hirama , Hideyuki Tanaka , Seiji Niwa , Akiyo Yamazaki , Takao Ikenoue , Koji Ohsumi
发明人： Ryusuke Hirama , Hideyuki Tanaka , Seiji Niwa , Akiyo Yamazaki , Takao Ikenoue , Koji Ohsumi
IPC分类号： A61K31/553 , A61K31/55 , A61K31/551 , C07D498/02 , C07D491/02 , C07D487/02
CPC分类号： C07D487/04
摘要： The following fused polycyclic compound, analogues thereof or pharmaceutically acceptable salts thereof have an effect of increasing the sugar-transporting capacity and an effect of lowering the blood glucose level and, therefore, they are useful for preventing and/or treating diabetes and the like. wherein R is a methoxy group, Y is a (2-thiazolyl)-2-ethylcarbonyl group, R10 and R13 are hydrogen atoms, and R11 and R12 are methyl groups.
摘要翻译： 下列稠合多环化合物，其类似物或其药学上可接受的盐具有增加糖输送能力和降低血糖水平的作用，因此它们可用于预防和/或治疗糖尿病等。 其中R是甲氧基，Y是（2-噻唑基）-2-乙基羰基，R 10和R 13是氢原子，R 11 R 12和R 12是甲基。
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公开(公告)号：US07326701B2
公开(公告)日：2008-02-05
申请号：US11398675
申请日：2006-04-06
申请人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
发明人： Yukio Iino , Takao Ikenoue , Nobuo Kondo , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Masuzawa , Fumio Ohta , Akiyo Yamazaki , Seiji Niwa , Takashi Yamamoto
IPC分类号： C07D487/04 , A61K31/5517 , A61P3/10
CPC分类号： C07D487/04 , A61K31/5517 , A61K31/554 , C07D243/10 , C07D513/04
摘要： An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.
摘要翻译： 含有内酰胺化合物或其药学上可接受的盐的增加糖输送能力的药剂和用于预防和/或治疗糖尿病，糖尿病性周围神经病变，糖尿病性肾病，糖尿病性视网膜病变，糖尿病性大血管病变，葡萄糖耐量异常或脂肪变性的药剂 作为活性成分。
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8.发明申请Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof 有权具有杂环的稠合多环化合物及其药物用途公开(公告)号：US20060194789A1
公开(公告)日：2006-08-31
申请号：US11414499
申请日：2006-05-01
申请人： Ryusuke Hirama , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
发明人： Ryusuke Hirama , Seiji Niwa , Hideyuki Tanaka , Toshihiro Hatanaka , Yoko Masuzawa , Akiyo Yamazaki , Takao Ikenoue , Nobuo Kondo , Wataru Miyanaga , Masaru Takayanagi
IPC分类号： A61K31/55 , A61K31/551 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R′ represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R″ represent a hydrogen atom.
摘要翻译： 本发明提供下式的稠合多环化合物，其类似物和其药学上可接受的盐; 以及增加糖输送能力的药剂，含有上述化合物的降血糖药和药物组合物。 该稠合多环化合物具有很高的药用性质，副作用少，对糖尿病具有治疗作用。 其中R表示烷氧基，R'表示恶唑基丙酰基或噻唑基丙酰基，R“表示氢原子。
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公开(公告)号：US07956041B2
公开(公告)日：2011-06-07
申请号：US10972743
申请日：2004-10-26
申请人： Katsumi Maezono , Nozomu Ishida , Koji Ohsumi , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Kageyama , Nobuo Kondo
发明人： Katsumi Maezono , Nozomu Ishida , Koji Ohsumi , Hiroyuki Matsueda , Toshihiro Hatanaka , Ryusuke Hirama , Yoko Kageyama , Nobuo Kondo
CPC分类号： A61K31/426 , A61K31/155 , A61K31/175 , A61K31/197 , A61K31/4439 , A61K31/4453 , A61K31/64 , A61K31/7056 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The invention provides a prophylactic and therapeutic agent of diabetes mellitus, including a combination of an inhibitor of renal glucose reabsorption and a hypoglycemic agent. In accordance with the invention, hyperglycemia after meals, between meals and during fasting can be ameliorated. More specifically, in accordance with the invention, a therapeutic effect of diabetes mellitus as never been obtained by the hypoglycemic agents of the related art can be achieved.
摘要翻译： 本发明提供糖尿病的预防和治疗剂，包括肾葡萄糖再吸收抑制剂和降血糖药的组合。 根据本发明，可以改善膳食后，膳食间和禁食期间的高血糖。 更具体地，根据本发明，可以实现由相关领域的降血糖剂从未获得的糖尿病的治疗效果。
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公开(公告)号：US07834006B2
公开(公告)日：2010-11-16
申请号：US11486213
申请日：2006-07-14
申请人： Ryusuke Hirama , Hideyuki Tanaka , Seiji Niwa , Akiyo Yamazaki , Takao Ikenoue , Koji Ohsumi
发明人： Ryusuke Hirama , Hideyuki Tanaka , Seiji Niwa , Akiyo Yamazaki , Takao Ikenoue , Koji Ohsumi
IPC分类号： A61P3/04 , A61P3/10 , A61P9/10 , A61P13/12 , A61P25/02 , A61P43/00 , A61K31/551 , C07D487/04
CPC分类号： C07D487/04
摘要： The following fused polycyclic compound, analogues thereof or pharmaceutically acceptable salts thereof have an effect of increasing the sugar-transporting capacity and an effect of lowering the blood glucose level and, therefore, they are useful for preventing and/or treating diabetes and the like. wherein R is a methoxy group, Y is a (2-thiazolyl)-2-ethylcarbonyl group, R10 and R13 are hydrogen atoms, and R11 and R12 are methyl groups.
摘要翻译： 下列稠合多环化合物，其类似物或其药学上可接受的盐具有增加糖输送能力和降低血糖水平的作用，因此它们可用于预防和/或治疗糖尿病等。 其中R是甲氧基，Y是（2-噻唑基）-2-乙基羰基，R10和R13是氢原子，R11和R12是甲基。
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