公开(公告)号：US08658237B2

公开(公告)日：2014-02-25

申请号：US13321299

申请日：2010-05-21

申请人： Yuko Fukui ,  Sumio Asami ,  Mitsuru Maeda

发明人： Yuko Fukui ,  Sumio Asami ,  Mitsuru Maeda

IPC分类号： A23L1/48 ,  C07D311/76

CPC分类号： C07D311/64 ,  A23F3/16 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/122 ,  A61K31/353 ,  C07C62/38 ,  C07D311/04 ,  C07D311/62 ,  A23V2200/332

摘要： The object of the present invention is to provide an anti-obesity agent which contains a tea-derived component and which is safe and does not compromise the flavor of foods and beverages.According to the present invention, a safe and palatable anti-obesity agent can be provided by incorporating a benzotropolone ring-containing compound which has tea-derived, high inhibitory activities against lipase and alfa-glucosidase. The anti-obesity agent of the present invention does not compromise the flavor of foods and beverage, has palatability, and can be used in various use applications including foods and beverages intended for health enhancement such as reduction in triglycerides.

摘要翻译： 本发明的目的是提供一种含有茶衍生成分的抗肥胖剂，其是安全的并且不损害食品和饮料的风味。 根据本发明，可以通过掺入具有茶衍生，对脂肪酶和α-葡糖苷酶的高抑制活性的含有苯佐龙酮酮环的化合物来提供安全可口的抗肥胖剂。 本发明的抗肥胖剂不损害食品和饮料的味道，具有适口性，并且可以用于各种用途，包括用于健康增强的食品和饮料，例如甘油三酯的还原。

公开(公告)号：US20120065410A1

公开(公告)日：2012-03-15

申请号：US13321299

申请日：2010-05-21

申请人： Yuko Fukui ,  Sumio Asami ,  Mitsuru Maeda

发明人： Yuko Fukui ,  Sumio Asami ,  Mitsuru Maeda

IPC分类号： C07D311/04

CPC分类号： C07D311/64 ,  A23F3/16 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/122 ,  A61K31/353 ,  C07C62/38 ,  C07D311/04 ,  C07D311/62 ,  A23V2200/332

摘要： The object of the present invention is to provide an anti-obesity agent which contains a tea-derived component and which is safe and does not compromise the flavor of foods and beverages.According to the present invention, a safe and palatable anti-obesity agent can be provided by incorporating a benzotropolone ring-containing compound which has tea-derived, high inhibitory activities against lipase and alfa-glucosidase. The anti-obesity agent of the present invention does not compromise the flavor of foods and beverage, has palatability, and can be used in various use applications including foods and beverages intended for health enhancement such as reduction in triglycerides.

摘要翻译： 本发明的目的是提供一种含有茶衍生成分的抗肥胖剂，其是安全的并且不损害食品和饮料的风味。 根据本发明，可以通过掺入具有茶衍生，对脂肪酶和α-葡糖苷酶的高抑制活性的含有苯佐龙酮酮环的化合物来提供安全可口的抗肥胖剂。 本发明的抗肥胖剂不损害食品和饮料的味道，具有适口性，并且可以用于各种用途，包括用于健康增强的食品和饮料，例如甘油三酯的还原。

公开(公告)号：US07989492B2

公开(公告)日：2011-08-02

申请号：US11597291

申请日：2005-05-26

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

IPC分类号： A61K31/353

CPC分类号： C07D311/62 ,  A23L33/105

摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.

摘要翻译： 本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有 掺入其中的这种脂肪酶活性抑制剂。 本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。 本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。 本发明的另一个目的是提供抗氧化剂。 为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。 结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。 本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

公开(公告)号：US20110118344A1

公开(公告)日：2011-05-19

申请号：US11630132

申请日：2005-06-20

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami

IPC分类号： A61K31/352 ,  C07D407/14 ,  C12P17/16 ,  A61P3/06 ,  A61P3/04

CPC分类号： C07D407/14 ,  A23F3/163 ,  A23F5/243 ,  A23L2/52 ,  A23L33/105

摘要： This invention provides, a novel polyphenol compound having lipase inhibitory activity derived from tealeaves, a process for the preparation of the compound, and foods and/or beverages and pharmaceutical drugs containing the compound.Particularly, this invention provides a novel dimer compound of formula: obtained by oxidative polymerization of epigallocatechin-3-O-gallate, a main catechin component of oolong tea, with a tealeaf enzyme (polyphenol oxidase), as well as foods and/or beverages and pharmaceutical compositions containing said novel compound which suppress absorption of dietary lipids and suppresses increase of blood triglyceride.

摘要翻译： 本发明提供一种新型的具有来源于茶叶的脂肪酶抑制活性的多酚化合物，制备该化合物的方法，以及含有该化合物的食品和/或饮料和药物。 特别地，本发明提供了一种新型的二聚体化合物，其通过用茶叶酶（多酚氧化酶）以及食品和/或饮料的乌龙茶的主要儿茶素组分氧化聚合得到。 以及含有抑制饮食脂质吸收并抑制血液甘油三酯增加的新化合物的药物组合物。

公开(公告)号：US07939559B2

公开(公告)日：2011-05-10

申请号：US11631506

申请日：2005-07-05

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

IPC分类号： A61K31/353

CPC分类号： A61K36/82 ,  A23F3/163 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K31/353 ,  C07D311/62 ,  C07D493/14 ,  A23V2250/21 ,  A23V2250/214 ,  A23V2200/332 ,  A23V2200/326

摘要： The present invention provides lipase inhibitors containing flavan-3-ol monomers or acylates thereof derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of flavan-3-ol monomers represented by the formula: wherein R1 and R3 independently represent H or OH, R2 represents H, R4 represents H, G, 3MeG or p-cou, R5 represents H or G, R4′ and R5′ independently represent H or G, R4″ represents H or G, and G, 3MeG and p-cou respectively represent the groups of the formulae: or acylates thereof; as well as foods and beverages and medicines containing said lipase inhibitors.

摘要翻译： 本发明提供了含有衍生自茶的黄烷-3-醇单体或其酰化物以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。 更具体地，本发明提供了含有下式所示的黄烷-3-醇单体中的至少一种的脂肪酶抑制剂：其中R1和R3独立地表示H或OH，R2表示H，R4表示H，G，3MeG或p-cou R5代表H或G，R4'和R5'独立地表示H或G，R4“表示H或G，G，3MeG和p-cou分别表示下式的基团：或其酰化物; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

公开(公告)号：US20090042812A1

公开(公告)日：2009-02-12

申请号：US12285144

申请日：2008-09-30

申请人： Yuko Fukui ,  Masaaki Nakai ,  Sumio Asami

发明人： Yuko Fukui ,  Masaaki Nakai ,  Sumio Asami

IPC分类号： A61K31/7034 ,  C07H15/207

CPC分类号： A61K31/7024 ,  A23F3/16 ,  A23F3/18 ,  A23F3/34 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/214 ,  A23V2250/21 ,  A23V2200/02 ,  A23V2200/30

摘要： The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines containing said inhibitory agents.The present invention provides lipase inhibitory agents comprising at least one of compounds represented by formula I below: wherein R1, R2 and R3 independently represent H or a gallic acid residue, and R4 and R5 represent H or a gallic acid residue, or R4 and R5 together form an HHDP group represented by the formula below: provided that at least two of R1 to R5 represent a gallic acid residue or when all of R1, R2 and R3 are H, R4 and R5 together form the HHDP group; as well as foods and beverages and medicines containing said lipase inhibitory agents.

摘要翻译： 本发明提供脂肪酶抑制剂，其包含从茶或Tellima grandiflora分离的鞣酸单宁或鞣花素组分，以及含有所述抑制剂的食品和饮料和药物。 本发明提供脂肪酶抑制剂，其包含至少一种以下式I表示的化合物：其中R1，R2和R3独立地表示H或没食子酸残基，R4和R5表示H或没食子酸残基，或R4和R5 一起形成由下式表示的HHDP基团：条件是R 1至R 5中至少两个表示没食子酸残基，或者当R1，R2和R3全部为H时，R4和R5一起形成HHDP基团; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

公开(公告)号：US08668921B2

公开(公告)日：2014-03-11

申请号：US11631507

申请日：2005-07-05

申请人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

发明人： Masaaki Nakai ,  Yuko Fukui ,  Sumio Asami ,  Fumio Hashimoto

IPC分类号： A61K31/353 ,  A61P1/00 ,  A61K31/7048 ,  A61K31/355 ,  A61K31/375 ,  A61K31/202 ,  A61K31/195 ,  A61K31/015

CPC分类号： A61K36/82 ,  A23F3/163 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A23V2200/332 ,  A23V2250/21 ,  A23V2250/214

摘要： The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula: wherein G represents a galloyl group; theasinensins represented by the formula: wherein R1 represents G or H, and R2 represents G; and theaflavins represented by the formula: wherein R1 and R2 independently represent G or H; as well as foods and beverages and medicines containing said lipase inhibitors.

摘要翻译： 本发明提供含有衍生自茶的黄烷-3-醇的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。 更具体地，本发明提供了含有下式表示的至少一种ass胺的脂肪酶抑制剂：其中，G表示加成酰基; 由下式表示的亚敏素：其中R1表示G或H，R2表示G; 和由下式表示的茶黄素：其中R1和R2独立地表示G或H; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

公开(公告)号：US20120329862A1

公开(公告)日：2012-12-27

申请号：US13336070

申请日：2011-12-23

申请人： Masaaki NAKAI ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki NAKAI ,  Yuko Fukui ,  Sumio Asami

IPC分类号： A61K31/353 ,  A61P3/06

CPC分类号： C07D407/14 ,  A23F3/163 ,  A23F5/243 ,  A23L2/52 ,  A23L33/105

摘要： This invention provides, a novel polyphenol compound having lipase inhibitory activity derived from tealeaves, a process for the preparation of the compound, and foods and/or beverages and pharmaceutical drugs containing the compound.Particularly, this invention provides a novel dimer compound of formula: obtained by oxidative polymerization of epigallocatechin-3-O-gallate, a main catechin component of oolong tea, with a tealeaf enzyme (polyphenol oxidase), as well as foods and/or beverages and pharmaceutical compositions containing said novel compound which suppress absorption of dietary lipids and suppresses increase of blood triglyceride.

摘要翻译： 本发明提供一种新型的具有来源于茶叶的脂肪酶抑制活性的多酚化合物，制备该化合物的方法，以及含有该化合物的食品和/或饮料和药物。 特别地，本发明提供了一种新型的二聚体化合物，其通过用茶叶酶（多酚氧化酶）以及食品和/或饮料的乌龙茶的主要儿茶素组分氧化聚合得到。 以及含有抑制饮食脂质吸收并抑制血液甘油三酯增加的新化合物的药物组合物。

公开(公告)号：US20110124887A1

公开(公告)日：2011-05-26

申请号：US12872872

申请日：2010-08-31

申请人： Masaaki NAKAI ,  Yuko Fukui ,  Sumio Asami

发明人： Masaaki NAKAI ,  Yuko Fukui ,  Sumio Asami

IPC分类号： C07D407/14

CPC分类号： C07D311/62 ,  A23L33/105

摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.

摘要翻译： 本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有 掺入其中的这种脂肪酶活性抑制剂。 本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。 本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。 本发明的另一个目的是提供抗氧化剂。 为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。 结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。 本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

公开(公告)号：US07754695B2

公开(公告)日：2010-07-13

申请号：US12285144

申请日：2008-09-30

申请人： Yuko Fukui ,  Masaaki Nakai ,  Sumio Asami

发明人： Yuko Fukui ,  Masaaki Nakai ,  Sumio Asami

IPC分类号： A61K31/70 ,  A01N43/04

CPC分类号： A61K31/7024 ,  A23F3/16 ,  A23F3/18 ,  A23F3/34 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/214 ,  A23V2250/21 ,  A23V2200/02 ,  A23V2200/30

摘要： The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines containing said inhibitory agents.The present invention provides lipase inhibitory agents comprising at least one of compounds represented by formula I below: wherein R1, R2 and R3 independently represent H or a gallic acid residue, and R4 and R5 represent H or a gallic acid residue, or R4 and R5 together form an HHDP group represented by the formula below: provided that at least two of R1 to R5 represent a gallic acid residue or when all of R1, R2 and R3 are H, R4 and R5 together form the HHDP group; as well as foods and beverages and medicines containing said lipase inhibitory agents.

摘要翻译： 本发明提供脂肪酶抑制剂，其包含从茶或Tellima grandiflora分离的鞣酸单宁或鞣花素组分，以及含有所述抑制剂的食品和饮料和药物。 本发明提供脂肪酶抑制剂，其包含至少一种以下式I表示的化合物：其中R1，R2和R3独立地表示H或没食子酸残基，R4和R5表示H或没食子酸残基，或R4和R5 一起形成由下式表示的HHDP基团：条件是R 1至R 5中至少两个表示没食子酸残基，或者当R1，R2和R3全部为H时，R4和R5一起形成HHDP基团; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。