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公开(公告)号：US20130012454A1
公开(公告)日：2013-01-10
申请号：US13389919
申请日：2010-08-11
申请人： Yun Mo , Mahendra Dedhiya , Anil Chhettry , Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
发明人： Yun Mo , Mahendra Dedhiya , Anil Chhettry , Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
摘要： The present invention relates to orally disintegrating or dissolving pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well to various methods and processes for the preparation and use of the compositions.
摘要翻译： 本发明涉及口服崩解或溶解包含利那洛肽或其药学上可接受的盐的药物组合物，以及用于制备和使用组合物的各种方法和方法。
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公开(公告)号：US20110059903A1
公开(公告)日：2011-03-10
申请号：US12851330
申请日：2010-08-05
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译： 本发明涉及包含利那洛肽的稳定组合物，以及用于制备和使用组合物的各种方法和方法。
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3.发明授权Stable solid formulation of a GC-C receptor agonist polypeptide suitable for oral administration 有权适用于口服给药的GC-C受体激动剂多肽的稳定的固体制剂公开(公告)号：US08802628B2
公开(公告)日：2014-08-12
申请号：US12541410
申请日：2009-08-14
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
CPC分类号： A61J3/00 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/167 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10
摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译： 适用于口服给药的利那洛肽的固体稳定制剂在本文中描述为制备这些制剂的方法。 本文描述的制剂含有由氨基酸序列Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr（“linaclotide”; SEQ ID NO：1）或其药学上可接受的盐组成的多肽。 本文所述的利那洛肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。
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公开(公告)号：US08748573B2
公开(公告)日：2014-06-10
申请号：US12851330
申请日：2010-08-05
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译： 本发明涉及包含利那洛肽的稳定组合物，以及用于制备和使用组合物的各种方法和方法。
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5.发明申请Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration 审中-公开适用于口服给药的GC-C受体激动剂多肽的稳定制剂公开(公告)号：US20120213846A1
公开(公告)日：2012-08-23
申请号：US13059154
申请日：2009-08-14
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
CPC分类号： A61K9/50 , A61J3/00 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/167 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译： 适用于口服给药的利那洛肽的固体稳定制剂在本文中描述为制备这些制剂的方法。 本文描述的制剂含有由氨基酸序列Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr（“linaclotide”）或其药学上可接受的盐组成的多肽。 本文所述的利那洛肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。
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6.发明申请Stable Solid Formulation of A GC-C Receptor Agonist Polypeptide Suitable for Oral Administration 有权适用于口服给药的GC-C受体激动剂多肽的稳定制剂公开(公告)号：US20100048489A1
公开(公告)日：2010-02-25
申请号：US12541410
申请日：2009-08-14
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
CPC分类号： A61J3/00 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/167 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10
摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译： 适用于口服给药的利那洛肽的固体稳定制剂在本文中描述为制备这些制剂的方法。 本文描述的制剂含有由氨基酸序列Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr（“linaclotide”）或其药学上可接受的盐组成的多肽。 本文所述的利那洛肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。
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公开(公告)号：US20130059797A1
公开(公告)日：2013-03-07
申请号：US13505926
申请日：2010-11-03
申请人： Jeffrey Johnston , Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Bernard Joseph Lavins , Mahendra Dedhiya , Harvey Schneier
发明人： Jeffrey Johnston , Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Bernard Joseph Lavins , Mahendra Dedhiya , Harvey Schneier
摘要： The invention provides methods for treating a patient with chronic constipation by administering a therapeutically effective dose of linaclotide.
摘要翻译： 本发明提供了通过施用治疗有效剂量的利那洛肽来治疗患有慢性便秘的患者的方法。
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8.发明申请Stable Solid Formulation of Therapeutic Polypeptides Suitable for Oral Administration 审中-公开适用于口服给药的治疗性多肽的稳定制剂公开(公告)号：US20120009225A1
公开(公告)日：2012-01-12
申请号：US13062332
申请日：2009-08-14
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
CPC分类号： A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/00 , A61K47/18 , A61K47/36 , A61K47/38
摘要： Solid, stable formulations of therapeutic polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The therapeutic polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译： 适用于口服给药的治疗性多肽的固体稳定制剂在本文中描述为制备这些制剂的方法。 本文所述的治疗性多肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。
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9.发明申请Stable Solid Formulations of GC-C Receptor Agonist Polypeptides Suitable for Oral Administration 审中-公开适用于口服给药的GC-C受体激动剂多肽的稳定固体制剂公开(公告)号：US20120039949A1
公开(公告)日：2012-02-16
申请号：US13062324
申请日：2009-08-14
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
CPC分类号： A61K38/1709 , A61K9/1676 , A61K9/5078 , A61K31/085 , A61K31/235 , A61K31/355 , A61K45/06 , A61K2300/00
摘要： Solid, stable formulations of GC-C receptor agonist polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The GC-C receptor agonist polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译： 本文描述了适用于口服给药的固体，稳定的GC-C受体激动剂多肽制剂，作为制备这些制剂的方法。 本文所述的GC-C受体激动剂多肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。
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