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    Method of Judging Grade of Malignancy of Carcinoma Cell
    1.
    发明申请
    Method of Judging Grade of Malignancy of Carcinoma Cell 失效
    判断癌细胞恶性程度的方法

    公开(公告)号：US20090004647A1

    公开(公告)日：2009-01-01

    申请号：US11658784

    申请日：2005-07-29

    申请人： Yutaka Miura ,  Makoto Kawaguchi ,  Hirotaka Iwase ,  Minoru Hamazaki ,  Jung Cha-Gyun ,  Hitoo Nishino

    发明人： Yutaka Miura ,  Makoto Kawaguchi ,  Hirotaka Iwase ,  Minoru Hamazaki ,  Jung Cha-Gyun ,  Hitoo Nishino

    IPC分类号： C12Q1/68 ,  C12Q1/02 ,  C07K16/18

    CPC分类号： G01N33/57496 ,  C07K16/30 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118

    摘要： Means for easily determining the grade of malignancy of cancer cells. The amount of ATBF1 in the whole cell structure of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Alternatively, the amount of ATBF1 in the nuclei of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Still alternatively, the amount of ATBF1 in the cytoplasms of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. In a preferred from, at least one of (1) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 10 of an ATBF1 gene, (2) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 11 of an ATBF1 gene, and (3) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 3 of an ATBF1 gene is detected as the amount of ATBF1.

    摘要翻译： 用于容易确定癌细胞恶性程度的方法。 检测从生物体分离出的检测癌细胞的全细胞结构中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。 或者，检测从活体分离的检测癌细胞的细胞核中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。 或者，检测从活体分离的检测癌细胞的细胞质中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。 优选地，（1）与ATBF1基因的外显子10相对应的区域的核内存在量和/或胞质内存在的量中的至少一种，（2）核内存在量和/或胞质内存在的量对应于 ATBF1基因的外显子11，（3）ATBF1基因的外显子3相应的区域的核内存在和/或胞质内存在量被检测为ATBF1的量。

    Method of judging grade of malignancy of carcinoma cell using ATBF-1
    2.
    发明授权
    Method of judging grade of malignancy of carcinoma cell using ATBF-1 失效
    使用ATBF-1判断癌细胞恶性程度的方法

    公开(公告)号：US07871788B2

    公开(公告)日：2011-01-18

    申请号：US11658784

    申请日：2005-07-29

    申请人： Yutaka Miura ,  Makoto Kawaguchi ,  Hirotaka Iwase ,  Minoru Hamazaki ,  Jung Cha-Gyun ,  Hitoo Nishino

    发明人： Yutaka Miura ,  Makoto Kawaguchi ,  Hirotaka Iwase ,  Minoru Hamazaki ,  Jung Cha-Gyun ,  Hitoo Nishino

    IPC分类号： G01N33/574 ,  G01N33/53

    CPC分类号： G01N33/57496 ,  C07K16/30 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118

    摘要： Means for easily determining the grade of malignancy of cancer cells. The amount of ATBF1 in the whole cell structure of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Alternatively, the amount of ATBF1 in the nuclei of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Still alternatively, the amount of ATBF1 in the cytoplasms of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. In a preferred from, at least one of (1) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 10 of an ATBF1 gene, (2) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 11 of an ATBF1 gene, and (3) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 3 of an ATBF1 gene is detected as the amount of ATBF1.

    摘要翻译： 用于容易确定癌细胞恶性程度的方法。 检测从生物体分离出的检测癌细胞的全细胞结构中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。 或者，检测从活体分离的检测癌细胞的细胞核中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。 或者，检测从活体分离的检测癌细胞的细胞质中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。 优选地，（1）与ATBF1基因的外显子10相对应的区域的核内存在量和/或胞质内存在的量中的至少一种，（2）核内存在量和/或胞质内存在的量对应于 ATBF1基因的外显子11，（3）ATBF1基因的外显子3相应的区域的核内存在和/或胞质内存在量被检测为ATBF1的量。

    Reversible thermosensitive recording medium
    4.
    发明授权
    Reversible thermosensitive recording medium 失效
    可逆热敏记录介质

    公开(公告)号：US5426086A

    公开(公告)日：1995-06-20

    申请号：US300033

    申请日：1994-09-02

    申请人： Yoshihiko Hotta ,  Makoto Kawaguchi ,  Tetsuya Amano

    发明人： Yoshihiko Hotta ,  Makoto Kawaguchi ,  Tetsuya Amano

    IPC分类号： B41M5/36 ,  B41M5/26

    CPC分类号： B41M5/363

    摘要： A reversible thermosensitive recording medium includes a reversible thermosensitive recording layer which is composed of a matrix resin and an organic low-molecular material which is dispersed in the matrix resin, the transparency of the reversible thermosensitive recording layer being reversibly changeable depending upon the temperature of the reversible thermosensitive recording layer, wherein the reversible thermosensitive recording layer has a softening initiation temperature T.sub.A, the organic low-molecular-weight material has a higher crystallization temperature T.sub.B1 which is 80.degree. C. or more and a lower crystallization temperature T.sub.B2, the softening initiation temperature T.sub.A is between the higher crystallization temperature T.sub.B1 and the lower crystallization temperature T.sub.B2, and the higher crystallization temperature T.sub.B1 and the lower crystallization temperature T.sub.B2 satisfies the relationship of T.sub.B1 -T.sub.B2 .gtoreq.40.degree. C.

    摘要翻译： 可逆热敏记录介质包括由矩阵树脂和分散在基质树脂中的有机低分子材料组成的可逆热敏记录层，可逆热敏记录层的透明度可根据 可逆热敏记录层，其中可逆热敏记录层具有软化初始温度TA，有机低分子量材料具有较高的结晶温度TB1，其结晶温度为80℃或更高，结晶温度TB2较低，软化引发 温度TA在较高的结晶温度TB1和较低的结晶温度TB2之间，较高的结晶温度TB1和较低的结晶温度TB2满足TB1-TB2> / = 40℃的关系。

    Stretch label attaching device
    7.
    发明授权
    Stretch label attaching device 有权
    拉伸标签贴装装置

    公开(公告)号：US07191514B2

    公开(公告)日：2007-03-20

    申请号：US10634784

    申请日：2003-08-06

    申请人： Makoto Kawaguchi ,  Hideo Ichikawa ,  Kotaro Koide ,  Masashi Hasegawa ,  Toshihide Tomotaka ,  Tomokazu Saitoh ,  Masaki Serizawa ,  Atsushi Inoue ,  Seiji Terazawa

    发明人： Makoto Kawaguchi ,  Hideo Ichikawa ,  Kotaro Koide ,  Masashi Hasegawa ,  Toshihide Tomotaka ,  Tomokazu Saitoh ,  Masaki Serizawa ,  Atsushi Inoue ,  Seiji Terazawa

    IPC分类号： B23P21/00

    CPC分类号： B65C9/262 ,  B65C3/065 ,  Y10T29/4987 ,  Y10T29/5333 ,  Y10T29/53657 ,  Y10T156/1002 ,  Y10T156/1744

    摘要： A stretch label attaching device for attaching a stretch label on a good, including an adapter supporting the label from the inside thereof and has an opening into which the good is inserted; an adapter support member configured to support a lower portion of the adapter and has an opening into which the good is inserted; and an adapter fixing member configured to fix the lower portion of the adapter together with the adapter support member. A method for attaching a stretch label on a good including setting a stretch label on the adapter mentioned above; inserting the good into the openings of the adapter and adapter support member while extending the label at a ratio not greater than 5 %; and releasing the stretch label attaching device from the good while holding the label, to attach the label to the predetermined position of the good.

    摘要翻译： 一种拉伸标签贴附装置，用于将拉伸标签附着在良好的拉伸标签上，包括从其内部支撑标签的适配器，并且具有插入商品的开口; 适配器支撑构件，其构造成支撑适配器的下部，并且具有插入物品的开口; 以及适配器固定构件，其构造成将适配器的下部与适配器支撑构件一起固定。 一种用于将拉伸标签附着在包括在上述适配器上设置拉伸标签的商品的方法; 将所述商品插入适配器和适配器支撑构件的开口中，同时以不大于5％的比例延伸标签; 并且在保持标签的同时从良好部件释放拉伸标签附着装置，以将标签附接到商品的预定位置。

    Method for producing reversible thermosensitive recording material
    8.
    发明授权
    Method for producing reversible thermosensitive recording material 失效
    生产可逆热敏记录材料的方法

    公开(公告)号：US5556827A

    公开(公告)日：1996-09-17

    申请号：US199797

    申请日：1994-02-22

    申请人： Toru Nogiwa ,  Yukio Konagaya ,  Yoshihiko Hotta ,  Kunichika Morohoshi ,  Makoto Kawaguchi ,  Akira Suzuki ,  Fumihito Masubuchi ,  Tsutomu Kagawa

    发明人： Toru Nogiwa ,  Yukio Konagaya ,  Yoshihiko Hotta ,  Kunichika Morohoshi ,  Makoto Kawaguchi ,  Akira Suzuki ,  Fumihito Masubuchi ,  Tsutomu Kagawa

    IPC分类号： B41M5/28 ,  B41M5/36

    CPC分类号： B41M5/363 ,  B41M5/28 ,  Y10S428/913 ,  Y10S428/914

    摘要： A method of producing a reversible thermosensitive recording material composed of a support, and a reversible thermosensitive recording layer formed thereon, which contains a matrix resin and an organic low-molecular weight material dispersed in the matrix resin, and capable of reversibly assuming a transparent state and a white opaque state depending upon the temperature thereof, is composed of the steps of applying a solution or dispersion of the matrix resin and the organic low-molecular-weight material dissolved or dispersed in a solvent to the support, and drying the applied solution or dispersion with the application of heat thereto in such a manner that when the temperature of the solution or dispersion applied side of the support it t.sub.1, and the temperature of the back side surface of the support, opposite to the solution or dispersion applied side thereof, is t.sub.2, t.sub.1 is lower than t.sub.2 (t.sub.1

    摘要翻译： 一种制备由支撑体和形成在其上的可逆热敏记录层组成的可逆热敏记录材料的方法，其包含分散在基质树脂中的基质树脂和有机低分子量材料，并且能够可逆地呈现透明状态 和根据其温度的白色不透明状态由以下步骤组成：将溶解或分散在溶剂中的基质树脂和有机低分子量材料的溶液或分散体施加到载体上，并将涂布的溶液 或分散体以这样的方式施加，即当其支撑体的溶液或分散体施加侧的温度t1以及与其溶液或分散体施加侧相反的载体的背侧表面的温度时 是t2，t1低于t2（t1

    Circuit for driving a load by using selectively one of two different DC power sources
    10.
    发明授权
    Circuit for driving a load by using selectively one of two different DC power sources 失效
    通过选择性地使用两个不同直流电源之一来驱动负载的电路

    公开(公告)号：US5283474A

    公开(公告)日：1994-02-01

    申请号：US720668

    申请日：1991-06-25

    申请人： Kunio Oi ,  Makoto Kawaguchi ,  Takashi Satoi

    发明人： Kunio Oi ,  Makoto Kawaguchi ,  Takashi Satoi

    IPC分类号： H03K17/18 ,  H03K17/22 ,  H03K17/945 ,  H02J3/02

    CPC分类号： H03K17/22 ,  H03K17/18 ,  H03K17/945 ,  Y10T307/336 ,  Y10T307/367 ,  Y10T307/766

    摘要： A circuit of a detection switch for generating an output signal for driving a load device in accordance with the detection result by a detector is composed with a reduced number of components externally attached to an IC substrate which mounts integrally main circuit units such as a power source circuit unit, a detection circuit unit and an output circuit unit. The output circuit unit comprises a comparator which compares a judgment signal from the detection circuit unit with a reference signal when the load device is driven by DC power, or compares the voltage of an external DC power source with a predetermined voltage when the device driven by AC power, and an output driver which generates a driving signal for the load device in response to the output signal from the comparator. The detection circuit unit produces the judgment signal only when either the output circuit unit or the power source circuit unit is active. Further, the output circuit unit comprises an NPN output circuit with a protection function for load short-circuit breaks its current path based on the judgment signal and a switching output circuit operating in engagement with the NPN output circuit. A limiter and a switching circuit are provided between the NPN output circuit and the load device. The limiter supplies the NPN output circuit with an excess current exceeding a predetermined value flowing through the load device and the switching circuit controls the limiter in accordance with the output from the switching output circuit. Further, the detection switch circuit is connected with a display lamp for displaying the operation of the switch, and the output circuit unit has a selector for selecting the judgment signal or the output signal for display according to the connection of an external jumper.

    摘要翻译： 用于根据检测器的检测结果产生用于驱动负载装置的输出信号的检测开关的电路由外部附接到IC基板的少量部件组成，该IC基板一体地安装有主电路单元，例如电源 电路单元，检测电路单元和输出电路单元。 输出电路单元包括比较器，当负载装置被直流电驱动时，将来自检测电路单元的判断信号与参考信号进行比较，或者当外部直流电源的电压与预定电压进行比较时， AC电源以及响应于来自比较器的输出信号产生用于负载装置的驱动信号的输出驱动器。 只有当输出电路单元或电源电路单元都有效时，检测电路单元产生判断信号。 此外，输出电路单元包括具有用于负载短路的保护功能的NPN输出电路，其基于判断信号而破坏其电流路径，以及与NPN输出电路接合操作的开关输出电路。 在NPN输出电路和负载装置之间设有限幅器和开关电路。 限幅器为NPN输出电路提供超过流过负载装置的预定值的过电流，开关电路根据开关输出电路的输出控制限幅器。 此外，检测开关电路与用于显示开关的操作的显示灯连接，并且输出电路单元具有用于根据外部跳线的连接来选择判断信号或用于显示的输出信号的选择器。