公开(公告)号：US09360594B2

公开(公告)日：2016-06-07

申请号：US13985109

申请日：2012-02-23

申请人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： C08L101/14 ,  G02B1/04 ,  G02C7/04 ,  C08G77/04 ,  C08L51/08 ,  C08F283/06

CPC分类号： G02B1/043 ,  C08F283/065 ,  C08L51/085 ,  C08L101/14

摘要： Silicone hydrogel contact lenses having a high water content are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer having a number average molecular weight of at least 7,000 daltons, and at least one vinyl-containing cross-linking agent. The lenses have average equilibrium water contents from about 30% wt/wt to about 70% wt/wt when fully hydrated. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了具有高水含量的硅氧烷水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自数均分子量为至少7,000道尔顿的第二硅氧烷单体的单元和至少一种含乙烯基交联剂。 当完全水合时，透镜具有约30重量％至约70重量％的平均水含量。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US09296159B2

公开(公告)日：2016-03-29

申请号：US13983306

申请日：2012-02-23

申请人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

发明人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

IPC分类号： G02B1/04 ,  B29D11/00 ,  C08F290/06

CPC分类号： B29D11/00125 ,  B29D11/0025 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在 在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当至少一种亲水乙烯基醚单体存在于 可聚合组合物的含量为1〜20单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20140009735A1

公开(公告)日：2014-01-09

申请号：US13983306

申请日：2012-02-23

申请人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

发明人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

IPC分类号： G02B1/04 ,  B29D11/00

CPC分类号： B29D11/00125 ,  B29D11/0025 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在 在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当至少一种亲水乙烯基醚单体存在于 可聚合组合物的含量为1〜20单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20120220690A1

公开(公告)日：2012-08-30

申请号：US13404040

申请日：2012-02-24

申请人： Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back ,  Ying Zheng

发明人： Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back ,  Ying Zheng

IPC分类号： G02C7/04

CPC分类号： G02C7/04 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了具有眼睛上可接受的能量损失水平的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自第二硅氧烷单体的单元，其是数均分子量至少为7,000道尔顿的双末端甲基丙烯酸酯封端的聚二甲基硅氧烷。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US08513325B2

公开(公告)日：2013-08-20

申请号：US13404027

申请日：2012-02-24

申请人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： G02B1/04 ,  C08F290/06 ,  C08F230/08 ,  C08F283/12 ,  G02C7/04

CPC分类号： G02B1/043 ,  B65B55/02 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.

摘要翻译： 制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。 如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。 水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

公开(公告)号：US08481662B2

公开(公告)日：2013-07-09

申请号：US13404040

申请日：2012-02-24

申请人： Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back ,  Ying Zheng

发明人： Ronghua Liu ,  Xinfeng Shi ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back ,  Ying Zheng

IPC分类号： C08F230/08 ,  C08F290/06 ,  G02B1/04

CPC分类号： G02C7/04 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses having ophthalmically acceptable levels of energy loss are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer which is a dual-end methacrylate end-capped polydimethylsiloxane having a number average molecular weight of at least 7,000 daltons. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

摘要翻译： 描述了具有眼睛上可接受的能量损失水平的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自第二硅氧烷单体的单元，其是数均分子量至少为7,000道尔顿的双末端甲基丙烯酸酯封端的聚二甲基硅氧烷。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20120220689A1

公开(公告)日：2012-08-30

申请号：US13404035

申请日：2012-02-24

申请人： Li Yao ,  Ye Hong ,  Yuwen Liu ,  Charlie Chen ,  Charles A. Francis ,  Arthur Back

发明人： Li Yao ,  Ye Hong ,  Yuwen Liu ,  Charlie Chen ,  Charles A. Francis ,  Arthur Back

IPC分类号： C08L43/04 ,  B65B55/02

CPC分类号： G02B1/043 ,  C08L83/12 ,  C08L101/14 ,  C08L33/10 ,  C08L33/08

摘要： Silicone hydrogel contact lenses that have good dimensional stability, are ophthalmically-acceptable, and can be manufactured without the use of alcohol solvents are formed from the reaction product of a polymerizable composition comprising at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 2,000; at least one bi-functional acrylate-containing siloxane monomer having a molecular weight of at least 3,000; and at least one hydrophilic vinyl-containing monomer, wherein the polymerizable composition has a molar ratio of total amount of mono-functional acrylate-containing siloxane monomer to total amount of bi-functional acrylate-containing siloxane monomer of at least 30:1, respectively.

摘要翻译： 由可聚合组合物的反应产物形成具有良好的尺寸稳定性的眼科学可接受的硅酮水凝胶隐形眼镜，并且可以制造不含醇溶剂的可聚合组合物，该可聚合组合物包含至少一种含单分子丙烯酸酯的含有单官能丙烯酸酯的硅氧烷单体 重量小于2000; 至少一种分子量至少为3,000的含二官能丙烯酸酯的硅氧烷单体; 和至少一种亲水性含乙烯基单体，其中所述可聚合组合物的含单体官能丙烯酸酯的硅氧烷单体的总量与含二官能丙烯酸酯的硅氧烷单体的总量的摩尔比分别为至少30:1 。

公开(公告)号：US20120216488A1

公开(公告)日：2012-08-30

申请号：US13404027

申请日：2012-02-24

申请人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： B65B55/02 ,  G02C7/04

CPC分类号： G02B1/043 ,  B65B55/02 ,  C08L101/14 ,  C08L83/04 ,  C08L51/085

摘要： Silicone hydrogel contact lenses are produced without using volatile organic solvents to extract materials from the polymerized contact lens bodies, and instead are washed with aqueous liquids. The silicone hydrogel contact lenses so produced have ophthalmically wettable lens surfaces. The hydrated silicone hydrogel contact lenses have diameters that are at least 24% larger than the diameters of the silicone hydrogel contact lenses prior to hydration or washing.

摘要翻译： 制造硅氧烷水凝胶隐形眼镜，而不使用挥发性有机溶剂从聚合的隐形眼镜体提取物质，而是用含水液体洗涤。 如此生产的硅酮水凝胶隐形眼镜具有眼睛可润湿的透镜表面。 水合硅酮水凝胶隐形眼镜的直径比水合或洗涤前的硅酮水凝胶隐形眼镜的直径大至少24％。

公开(公告)号：US09057822B2

公开(公告)日：2015-06-16

申请号：US13983774

申请日：2012-02-23

申请人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： G02B1/04 ,  C08F283/12 ,  C08F236/20 ,  C08F226/00 ,  C08F283/06 ,  C08L51/08 ,  C08J11/02

CPC分类号： G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

摘要翻译： 衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。

公开(公告)号：US20140016086A1

公开(公告)日：2014-01-16

申请号：US13983774

申请日：2012-02-23

申请人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

发明人： Yuwen Liu ,  Ye Hong ,  Junhao Ge ,  Yuan Xu ,  Charlie Chen ,  Charles A. Francis ,  Li Yao ,  Arthur Back

IPC分类号： G02C7/04

CPC分类号： G02B1/043 ,  C08F226/00 ,  C08F236/20 ,  C08F283/065 ,  C08F283/126 ,  C08J11/02 ,  C08L51/085 ,  C08L83/04 ,  C08L101/14

摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including a first siloxane monomer represented by formula (3): wherein m of formula (3) represents one integer from 3 to 10, n of formula (3) represents one integer from 1 to 10, R1 of formula (3) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (3) is independently either a hydrogen atom or a methyl group; and at least one vinyl ether-containing cross-linking agent are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described. In one example, the batches of silicone hydrogel contact lenses are dimensionally stable, and the method of making is a method of making dimensionally stable silicone hydrogel contact lenses.

摘要翻译： 衍生自包含由式（3）表示的第一硅氧烷单体的可聚合组合物的聚合性组合物的硅氧水凝胶隐形眼镜：式（3）的m表示3〜10的整数，式（3）的n表示1〜 10，式（3）的R 1为碳原子数1〜4的烷基，式（3）的各R 2独立地为氢原子或甲基。 和至少一种含乙烯基醚的交联剂。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。 在一个示例中，硅胶水凝胶隐形眼镜的批次是尺寸稳定的，并且制造方法是制备尺寸稳定的硅酮水凝胶隐形眼镜的方法。