-
公开(公告)号：US20120244071A1
公开(公告)日：2012-09-27
申请号：US13513708
申请日：2010-12-08
申请人： Yves Auberson , Emmanuelle Briard , David Orain
发明人： Yves Auberson , Emmanuelle Briard , David Orain
IPC分类号： A61K51/04 , A61B6/00 , A61B6/03 , C07C217/64 , C07F9/22
CPC分类号： C07C217/64 , C07C215/28 , C07F9/091 , C07F9/653
摘要： There are provided new iodo- and bromo-compounds, and their use as diagnostic agents and imaging agents for diseases and disorders wherein S1P receptor expression is altered.
摘要翻译： 提供了新的碘和溴化合物，以及它们作为其中S1P受体表达改变的疾病和病症的诊断剂和显像剂的用途。
-
公开(公告)号：US10450298B2
公开(公告)日：2019-10-22
申请号：US15544850
申请日：2016-01-20
IPC分类号： C07D401/14 , C07D413/12 , A61K51/04 , C07D401/12 , C07B59/00 , C07D413/14
摘要： Preparation of novel 2-benzyl-5-methyl-2H-tetrazole derivatives of the formula (I) for use as PET imaging agents. The present invention relates to novel compounds of formula (I) their preparation and use as PET imaging agents for imaging techniques and diagnostics in the field of diseases and disorders mediated by or related to the enzyme autotaxin.
-
公开(公告)号：US20080311038A1
公开(公告)日：2008-12-18
申请号：US12159744
申请日：2007-01-02
申请人： Yves Auberson , Mats Bergstroem , Emmanuelle Briard , Patrick Chene , Laurent Martarello , Joseph Schoepfer
发明人： Yves Auberson , Mats Bergstroem , Emmanuelle Briard , Patrick Chene , Laurent Martarello , Joseph Schoepfer
IPC分类号： A61K51/04 , C07D313/00
CPC分类号： C07D313/00 , A61K51/0412 , A61K51/0414 , C07D493/04 , G01N33/574
摘要： The present invention relates to novel radicicol derivatives of the formula I, in which R is R′, (CH2)nCOOR′ or (CH2)nCONHR′, wherein R′ is 11CH3, [3H]3C, [3H]2HC, [3H]H2C or (CH2)nHal, wherein Hal is 123I, 125I, 131I, I, 75Br, 76Br, 77Br, 82Br, Br, 18F or F, or R′ is (CH2)n-1[3H]HCHal or (CH2)n-1[3H]2CHal, wherein Hal is I, Br or F, and n is, each independently, 1, 2, 3 or 4, in free form or in salt form, to their preparation, to their use as radiotracers/markers and to compositions containing them.
摘要翻译： 本发明涉及式I的新的根赤壳菌素衍生物，其中R是R'，（CH2）nCOOR'或（CH2）nCONHR'，其中R'是11CH3，[3H] 3C，[3H] 2HC，[3H ]其中Hal为123I，125I，131I，I，75Br，76Br，77Br，82Br，Br，18F或F，或R'为（CH2）n-1 [3H] HCHal或（CH2 ）n-1 [3H] 2CHal，其中Hal为I，Br或F，n为各自独立地为1,2,3或4，为游离形式或盐形式，其制备方式为其作为放射性示踪剂的用途 /标记和含有它们的组合物。
-
公开(公告)号：US09334271B2
公开(公告)日：2016-05-10
申请号：US14353950
申请日：2012-10-26
申请人： Emmanuelle Briard , Pascal Furet , Andreas Lerchner , Peter Meier , Branko Radetich , David Andrew Sandham , Yanyi Zhu
发明人： Emmanuelle Briard , Pascal Furet , Andreas Lerchner , Peter Meier , Branko Radetich , David Andrew Sandham , Yanyi Zhu
IPC分类号： C07D487/04 , C07D473/16 , C07D519/00 , A61K31/5377 , A61K31/553 , C07D491/048 , C07D491/107
CPC分类号： C07D473/16 , A61K31/5377 , A61K31/553 , C07D487/04 , C07D491/048 , C07D491/107 , C07D519/00
摘要： The invention relates to PI3K inhibitors of the formula (I)• in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.
摘要翻译： 本发明涉及式（I）的PI3K抑制剂，其中所有变量如说明书中所定义，其制备，其医疗用途，特别是其在治疗癌症和神经变性疾病中的用途，以及 包括它们的药物。
-
5.发明授权公开(公告)号：US08093406B2
公开(公告)日：2012-01-10
申请号：US12500093
申请日：2009-07-09
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： C07D335/02
CPC分类号： C07D335/02 , C07D409/10 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
-
6.发明申请公开(公告)号：US20090054427A1
公开(公告)日：2009-02-26
申请号：US12196461
申请日：2008-08-22
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/5377 , C07D335/02 , A61K31/382 , A61P25/00 , C07D413/08
CPC分类号： C07D335/02 , C07D409/12
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
-
7.发明申请公开(公告)号：US20100056490A1
公开(公告)日：2010-03-04
申请号：US12500093
申请日：2009-07-09
申请人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
发明人： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC分类号： A61K31/397 , C07D401/12 , C07D205/02 , C07D335/02 , A61K31/4535 , A61K31/382 , A61P25/00 , A61P9/10
CPC分类号： C07D335/02 , C07D409/10 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.023 秒)
