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公开(公告)号：US20090011988A1
公开(公告)日：2009-01-08
申请号：US11929468
申请日：2007-10-30
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US20100130411A1
公开(公告)日：2010-05-27
申请号：US11934582
申请日：2007-11-02
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US08110548B2
公开(公告)日：2012-02-07
申请号：US11934582
申请日：2007-11-02
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US07423017B2
公开(公告)日：2008-09-09
申请号：US10271869
申请日：2002-10-16
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US07947650B2
公开(公告)日：2011-05-24
申请号：US11929468
申请日：2007-10-30
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/30
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US06608028B1
公开(公告)日：2003-08-19
申请号：US09723251
申请日：2000-11-27
申请人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K3810
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要： Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号：US06743894B1
公开(公告)日：2004-06-01
申请号：US09723254
申请日：2000-11-27
申请人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F Robinson , Nicholas J. Skelton
发明人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F Robinson , Nicholas J. Skelton
IPC分类号： C07K754
CPC分类号： C07K7/08 , A61K38/00 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/27 , A61K2300/00
摘要： Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译： 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的肽。 这些IGF激动剂肽可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号：US06420518B1
公开(公告)日：2002-07-16
申请号：US09337227
申请日：1999-06-22
申请人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： C07K764
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要： Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译： 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的肽。 这些IGF激动剂肽可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号：US06750321B1
公开(公告)日：2004-06-15
申请号：US09723185
申请日：2000-11-27
申请人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicolas J. Skelton
发明人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicolas J. Skelton
IPC分类号： C07K750
CPC分类号： C07K7/08 , A61K38/00 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/27 , A61K2300/00
摘要： Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号：US06620789B1
公开(公告)日：2003-09-16
申请号：US09723901
申请日：2000-11-28
IPC分类号： A61K3810
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K2319/00 , Y10S930/12 , A61K2300/00
摘要： Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful to increase serum and tissue levels of active IGFs in a mammal.
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