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公开(公告)号：US20090011988A1
公开(公告)日：2009-01-08
申请号：US11929468
申请日：2007-10-30
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US20100130411A1
公开(公告)日：2010-05-27
申请号：US11934582
申请日：2007-11-02
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US08110548B2
公开(公告)日：2012-02-07
申请号：US11934582
申请日：2007-11-02
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US07423017B2
公开(公告)日：2008-09-09
申请号：US10271869
申请日：2002-10-16
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US07947650B2
公开(公告)日：2011-05-24
申请号：US11929468
申请日：2007-10-30
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/30
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US06743894B1
公开(公告)日：2004-06-01
申请号：US09723254
申请日：2000-11-27
申请人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F Robinson , Nicholas J. Skelton
发明人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F Robinson , Nicholas J. Skelton
IPC分类号： C07K754
CPC分类号： C07K7/08 , A61K38/00 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/27 , A61K2300/00
摘要： Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译： 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的肽。 这些IGF激动剂肽可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号：US06608028B1
公开(公告)日：2003-08-19
申请号：US09723251
申请日：2000-11-27
申请人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K3810
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要： Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
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公开(公告)号：US06420518B1
公开(公告)日：2002-07-16
申请号：US09337227
申请日：1999-06-22
申请人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-yee Chen , Ross G. Clark , Andrea G. Cochran , Henry B. Lowman , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： C07K764
CPC分类号： C07K7/08 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , Y10S930/12 , Y10S930/26 , Y10S930/27 , A61K2300/00
摘要： Peptides are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist peptides are useful to increase serum and tissue levels of active IGFs in a mammal.
摘要翻译： 提供了抑制IGF与其任何一种结合蛋白而不是人IGF受体的相互作用的肽。 这些IGF激动剂肽可用于增加哺乳动物中活性IGF的血清和组织水平。
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公开(公告)号：US07235626B1
公开(公告)日：2007-06-26
申请号：US09592695
申请日：2000-06-13
CPC分类号： C07K1/047 , C07K7/06 , C07K7/08 , C07K14/70514 , C07K14/70535 , C07K14/71 , C12N15/1037 , C40B40/02
摘要： The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides with sequences favorable for energy stabilized conformations. A preferred embodiment of the invention is directed to peptides containing β-turn tetrapeptide that form structured β-hairpin scaffold in solution. Methods of selecting and using such peptides are provided herein, which are useful for mimicking in vivo molecular interactions and designing therapeutic agents. Thus, the invention has profound utility for biological studies and drug development.
摘要翻译： 本发明涉及涉及重要生物过程的肽或蛋白质分子的结构活性分析的模型系统。 由本发明提供的组合肽文库包含具有有利于能量稳定构象的序列的二硫键受限的环肽。 本发明的优选实施方案涉及在溶液中形成结构化β-发夹支架的含有β-转角四肽的肽。 本文提供了选择和使用这些肽的方法，其可用于模拟体内分子相互作用并设计治疗剂。 因此，本发明对生物学研究和药物开发具有深远的实用价值。
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