-
公开(公告)号:US20050282812A1
公开(公告)日:2005-12-22
申请号:US11155001
申请日:2005-06-16
申请人: Zachary Jones , Robert Groneberg , Mark Drew , Charles Eary
发明人: Zachary Jones , Robert Groneberg , Mark Drew , Charles Eary
IPC分类号: A61K31/498 , C07D241/36 , C07D241/42 , C07D403/06
CPC分类号: C07D241/44 , C07D241/42 , C07D403/06
摘要: This invention relates to inhibitors of CETP and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by CETP.
摘要翻译: 本发明涉及CETP抑制剂及其制备方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防由CETP介导的各种疾病的方法。
-
2.
公开(公告)号:US11858703B2
公开(公告)日:2024-01-02
申请号:US16847777
申请日:2020-04-14
申请人: Zachary Jones
发明人: Zachary Jones
CPC分类号: B65D55/028 , A47G29/30 , G07C9/00912 , G08B13/08 , H04W4/02
摘要: A food delivery system includes a food delivery container and a cell phone programmed to monitor for unauthorized access to food content provided in the food delivery container, once secured. The food delivery container has an internal volume, an opening, a cover to cover the opening to prevent access, and uncover the opening to allow access, a device for securing the cover and a sensing device for detecting whether the cover, after being positioned to cover the opening, is (still) secured over the opening, in reliance upon a state of the device for securing. The device for securing first implements a pairing or synchronizing operation with the cell phone. If the sensing device detects that the cover is not secured over the opening by the device for securing, after first being secured and armed thereon, the cell phone determines whether an authorized access has occurred.
-
公开(公告)号:US08163738B2
公开(公告)日:2012-04-24
申请号:US12064196
申请日:2006-08-17
申请人: George A. Doherty , Zachary Jones
发明人: George A. Doherty , Zachary Jones
IPC分类号: A61P37/02 , A61K31/5513 , C07D243/20
CPC分类号: C07D243/20
摘要: Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
摘要翻译: 提供了可用于通过Toll样受体TLR8调节信号传导的组合物和方法。 组合物和方法用于治疗自身免疫,炎症过敏,哮喘,移植物排斥,移植物抗宿主病,感染,败血症,癌症和免疫缺陷。
-
公开(公告)号:US20080306050A1
公开(公告)日:2008-12-11
申请号:US12064196
申请日:2006-08-17
申请人: George A. Doherty , Zachary Jones
发明人: George A. Doherty , Zachary Jones
IPC分类号: A61K31/5513 , C07D243/14 , A61P37/02
CPC分类号: C07D243/20
摘要: Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
摘要翻译: 提供了可用于通过Toll样受体TLR8调节信号传导的组合物和方法。 组合物和方法用于治疗自身免疫,炎症过敏,哮喘,移植物排斥,移植物抗宿主病,感染,败血症,癌症和免疫缺陷。
-
公开(公告)号:US20140088085A1
公开(公告)日:2014-03-27
申请号:US13979634
申请日:2012-01-12
申请人: Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
发明人: Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
IPC分类号: C07D223/16 , C07D243/14 , C07D487/04 , C07D401/12
CPC分类号: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
摘要: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
摘要翻译: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病,包括癌症,自身免疫性疾病,纤维化疾病,心血管疾病,感染性疾病,炎症性疾病,移植排斥反应或移植物抗宿主病。
-
公开(公告)号:US20110118235A1
公开(公告)日:2011-05-19
申请号:US12859182
申请日:2010-08-18
申请人: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
发明人: James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
IPC分类号: A61K31/55 , C07D403/10 , A61P37/02
CPC分类号: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
摘要: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
摘要翻译: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病,包括癌症,自身免疫性疾病,感染性疾病,炎性疾病,移植物排斥反应和移植物宿主病。
-
公开(公告)号:US20170112299A1
公开(公告)日:2017-04-27
申请号:US14922328
申请日:2015-10-26
申请人: Shaunta Jones , Zachary Jones
发明人: Shaunta Jones , Zachary Jones
IPC分类号: A47G9/02
CPC分类号: A47G9/0223
摘要: A baby blanket comprising a first layer of material having a first side and a second side, the first side having a first designed border, the second side having a second designed border, the first and second sides sharing a first perimeter surface; a second layer of material having a third side and a fourth side, the third side having a third designed border, the fourth side having a fourth designed border, the third and second sides sharing a second perimeter surface; the first layer of material stitched to the second layer of material at the first and second perimeter surfaces, the stitching located around the complete first and second perimeter surfaces except at a location on the top side of the first and second perimeter surfaces creating an opening extending a first length.
-
公开(公告)号:US08304407B2
公开(公告)日:2012-11-06
申请号:US13414579
申请日:2012-03-07
IPC分类号: A61P37/00 , A61K31/55 , C07D223/16 , C07D403/10
CPC分类号: C07D223/16
摘要: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
摘要翻译: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法用于治疗自身免疫,炎症过敏,哮喘,移植物排斥,移植物抗宿主病,感染,败血症,癌症和免疫缺陷。
-
公开(公告)号:US20120165317A1
公开(公告)日:2012-06-28
申请号:US13414579
申请日:2012-03-07
CPC分类号: C07D223/16
摘要: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
摘要翻译: 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法用于治疗自身免疫,炎症过敏,哮喘,移植物排斥,移植物抗宿主病,感染,败血症,癌症和免疫缺陷。
-
公开(公告)号:US08153622B2
公开(公告)日:2012-04-10
申请号:US12064193
申请日:2006-08-17
IPC分类号: A61P37/00 , A61K31/55 , C07D223/16 , C07D403/10
CPC分类号: C07D223/16
摘要: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.
-
-
-
-
-
-
-
-
-