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公开(公告)号：US20140066432A1
公开(公告)日：2014-03-06
申请号：US13979632
申请日：2012-01-12
IPC分类号： C07D413/10 , C07D223/16 , C07D403/10 , C07D295/192
CPC分类号： C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
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公开(公告)号：US10016440B2
公开(公告)日：2018-07-10
申请号：US13092088
申请日：2011-04-21
申请人： Robert Hershberg
发明人： Robert Hershberg
IPC分类号： A61P29/00 , A61K31/55 , A61K39/395 , A61K45/06 , C07K16/28 , C07K16/32 , A61K39/39 , C07K16/30 , A61K39/00
CPC分类号： A61K31/55 , A61K39/39 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K16/2863 , C07K16/2887 , C07K16/3046 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/732
摘要： The application relates to method of increasing antibody-dependent cellular cytotoxicity in a subject receiving therapeutic monoclonal antibody treatment. In some embodiments, methods are provided for administering to subject to a subject in need thereof a therapeutic antibody in conjunction with an ADCC enhancer molecule.
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公开(公告)号：US20160137608A1
公开(公告)日：2016-05-19
申请号：US14881906
申请日：2015-10-13
申请人： James Jeffry Howbert , Gregory N. Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachery Jones
发明人： James Jeffry Howbert , Gregory N. Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachery Jones
IPC分类号： C07D223/16 , C07D401/04 , C07D403/10 , C07D403/04 , C07D403/06 , C07D401/12
CPC分类号： C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：US20140088085A1
公开(公告)日：2014-03-27
申请号：US13979634
申请日：2012-01-12
申请人： Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
发明人： Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
IPC分类号： C07D223/16 , C07D243/14 , C07D487/04 , C07D401/12
CPC分类号： C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，纤维化疾病，心血管疾病，感染性疾病，炎症性疾病，移植排斥反应或移植物抗宿主病。
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公开(公告)号：US20130236449A1
公开(公告)日：2013-09-12
申请号：US13642057
申请日：2011-04-21
申请人： Robert Hershberg
发明人： Robert Hershberg
IPC分类号： A61K31/55 , A61K45/06 , A61K39/395
CPC分类号： A61K31/55 , A61K39/39 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K16/2863 , C07K16/2887 , C07K16/3046 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/732
摘要： The application relates to method of increasing antibody-dependent cellular cytotoxicity in a subject receiving therapeutic monoclonal antibody treatment. In some embodiments, methods are provided for administering to subject to a subject in need thereof a therapeutic antibody in conjunction with an ADCC enhancer molecule.
摘要翻译： 本申请涉及在接受治疗性单克隆抗体治疗的受试者中增加抗体依赖性细胞毒性的方法。 在一些实施方案中，提供了用于施用以治疗有需要的受试者与ADCC增强子分子结合的治疗性抗体的方法。
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公开(公告)号：US08242106B2
公开(公告)日：2012-08-14
申请号：US12533596
申请日：2009-07-31
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： A61K31/55 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/724 , A61K47/40 , A61K47/48969 , A61K47/6951 , B82Y5/00 , C07D223/16 , C08B37/0012 , Y02A50/393
摘要： The present invention is directed generally to stable formulations of a TLR agonist preferably a TLR7 or a TLR8 agonist, for use in the treatment of cancer, preferably solid tumors and lymphomas. Specifically, the present invention is directed to stable formulations of up to 50 mg/ml of a TLR agonist which comprise a cyclodextrin.
摘要翻译： 本发明一般涉及用于治疗癌症，优选实体瘤和淋巴瘤的TLR激动剂优选TLR7或TLR8激动剂的稳定制剂。 具体地，本发明涉及高达50mg / ml的包含环糊精的TLR激动剂的稳定制剂。
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公开(公告)号：US20110118235A1
公开(公告)日：2011-05-19
申请号：US12859182
申请日：2010-08-18
申请人： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
发明人： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones
IPC分类号： A61K31/55 , C07D403/10 , A61P37/02
CPC分类号： C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
摘要翻译： 提供了可用于通过Toll样受体TLR7和/或TLR8调节信号传导的组合物和方法。 组合物和方法可用于治疗或预防疾病，包括癌症，自身免疫性疾病，感染性疾病，炎性疾病，移植物排斥反应和移植物宿主病。
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公开(公告)号：US20120082658A1
公开(公告)日：2012-04-05
申请号：US13252146
申请日：2011-10-03
申请人： Robert Hershberg
发明人： Robert Hershberg
IPC分类号： A61K31/55 , A61P17/00 , A61P11/06 , A61K48/00 , A61K39/395 , A61K31/56 , A61K38/22 , A61K38/19 , A61P37/08 , A61P11/02
CPC分类号： A61K31/55 , A61K9/0043
摘要： The present invention is directed generally to a TLR8 agonist VTX-378, for use in the treatment or prevention of allergic diseases, including allergic rhinitis.
摘要翻译： 本发明一般涉及TLR8激动剂VTX-378，用于治疗或预防过敏性疾病，包括过敏性鼻炎。
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公开(公告)号：US20120003213A1
公开(公告)日：2012-01-05
申请号：US13092088
申请日：2011-04-21
申请人： Robert Hershberg
发明人： Robert Hershberg
IPC分类号： A61K39/395 , C07D403/10 , A61P29/00 , A61P35/00 , A61P35/02
CPC分类号： A61K31/55 , A61K39/39 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K16/2863 , C07K16/2887 , C07K16/3046 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/732
摘要： The application relates to method of increasing antibody-dependent cellular cytotoxicity in a subject receiving therapeutic monoclonal antibody treatment. In some embodiments, methods are provided for administering to subject to a subject in need thereof a therapeutic antibody in conjunction with an ADCC enhancer molecule.
摘要翻译： 本申请涉及在接受治疗性单克隆抗体治疗的受试者中增加抗体依赖性细胞毒性的方法。 在一些实施方案中，提供了用于施用以治疗有需要的受试者与ADCC增强子分子结合的治疗性抗体的方法。
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公开(公告)号：US20110092485A1
公开(公告)日：2011-04-21
申请号：US12859178
申请日：2010-08-18
申请人： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
发明人： James Jeffry Howbert , Gregory Dietsch , Robert Hershberg , Laurence E. Burgess , Joseph P. Lyssikatos , Brad Newhouse , Hong Woon Yang
IPC分类号： A61K31/55 , C07D223/16 , A61P11/06 , A61P37/02 , A61P35/00
CPC分类号： A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
摘要： Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.
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