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公开(公告)号：US20070287683A1
公开(公告)日：2007-12-13
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US08609632B2
公开(公告)日：2013-12-17
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , A61K31/715 , A01N43/04
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US20100305022A1
公开(公告)日：2010-12-02
申请号：US12788264
申请日：2010-05-26
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K38/00 , A61K31/727 , A61P7/02 , C12P19/04
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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4.发明授权Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping 有权通过链曲线或链映射评估低分子量肝素的混合物公开(公告)号：US08252597B1
公开(公告)日：2012-08-28
申请号：US13307243
申请日：2011-11-30
申请人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
发明人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
CPC分类号： G01N30/96 , G01N2030/8836
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
摘要翻译： 描述了分析多糖混合物的方法，例如肝素如普通肝素和依诺肝素。 在某些情况下，使用快速液相色谱（FPLC）和高液体色谱（HPLC）分析混合物，例如强阴离子交换HPLC。
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5.发明授权Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping 有权通过链曲线或链映射评估低分子量肝素的混合物公开(公告)号：US08617896B1
公开(公告)日：2013-12-31
申请号：US13529662
申请日：2012-06-21
申请人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
发明人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
IPC分类号： G01N33/00
CPC分类号： G01N30/96 , G01N2030/8836
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
摘要翻译： 描述了分析多糖混合物的方法，例如肝素如普通肝素和依诺肝素。 在某些情况下，使用快速液相色谱（FPLC）和高液体色谱（HPLC）分析混合物，例如强阴离子交换HPLC。
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公开(公告)号：US07968082B1
公开(公告)日：2011-06-28
申请号：US12011308
申请日：2008-01-25
IPC分类号： A61B5/055 , A61K31/727
CPC分类号： A61K31/727 , Y10S505/844
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR.
摘要翻译： 描述了分析多糖混合物的方法，例如肝素如依诺肝素。 在一些情况下，使用一维NMR和/或二维NMR分析混合物。
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公开(公告)号：US07816144B1
公开(公告)日：2010-10-19
申请号：US12619626
申请日：2009-11-16
申请人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
发明人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
CPC分类号： G01N30/96 , G01N2030/8836
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
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8.发明授权Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping 有权通过链曲线或链映射评估低分子量肝素的混合物公开(公告)号：US08076149B1
公开(公告)日：2011-12-13
申请号：US12878922
申请日：2010-09-09
申请人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
发明人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
CPC分类号： G01N30/96 , G01N2030/8836
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
摘要翻译： 描述了分析多糖混合物的方法，例如肝素如普通肝素和依诺肝素。 在某些情况下，使用快速液相色谱（FPLC）和高液体色谱（HPLC）分析混合物，例如强阴离子交换HPLC。
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9.发明授权Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping 有权通过链曲线或链映射评估低分子量肝素的混合物公开(公告)号：US07790466B1
公开(公告)日：2010-09-07
申请号：US12011436
申请日：2008-01-25
申请人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
发明人： Zachary Shriver , Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Jennifer Ozug , Steve Wudyka
CPC分类号： G01N30/96 , G01N2030/8836
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
摘要翻译： 描述了分析多糖混合物的方法，例如肝素如普通肝素和依诺肝素。 在某些情况下，使用快速液相色谱（FPLC）和高液体色谱（HPLC）分析混合物，例如强阴离子交换HPLC。
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公开(公告)号：US08435795B2
公开(公告)日：2013-05-07
申请号：US13008442
申请日：2011-01-18
申请人： Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Sucharita Roy
发明人： Daniela Beccati , Ishan Capila , Nur Sibel Gunay , Sucharita Roy
CPC分类号： C08B37/0078 , A61K31/727 , G01N24/08 , G01R33/46 , Y10T436/143333 , Y10T436/24
摘要： Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature that is indicative of the methods used to make the heparin preparation.
摘要翻译： 通过确定指示用于制备肝素制备的方法的结构性特征的不存在，存在或量来评价肝素制剂的方法，例如适合用作药物或用于制备药物的方法。
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