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公开(公告)号：US20070287683A1
公开(公告)日：2007-12-13
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US08609632B2
公开(公告)日：2013-12-17
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , A61K31/715 , A01N43/04
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US20100305022A1
公开(公告)日：2010-12-02
申请号：US12788264
申请日：2010-05-26
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K38/00 , A61K31/727 , A61P7/02 , C12P19/04
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US08101733B1
公开(公告)日：2012-01-24
申请号：US11426765
申请日：2006-06-27
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： A61K31/727 , C08B37/0075
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysaccharides in the mixture are chemically modified prior to analysis.
摘要翻译： 描述了使用减少末端标记来分析多糖混合物的方法，例如肝素或LMWH。 通常，多糖的混合物包括具有所需结构部分的多糖。 在一些情况下，混合物中的一种或多种多糖在分析之前被化学修饰。
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公开(公告)号：US08512969B2
公开(公告)日：2013-08-20
申请号：US13465639
申请日：2012-05-07
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： A61K31/727
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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6.发明申请公开(公告)号：US20060024664A1
公开(公告)日：2006-02-02
申请号：US11183323
申请日：2005-07-15
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/00
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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公开(公告)号：US08173384B2
公开(公告)日：2012-05-08
申请号：US12509774
申请日：2009-07-27
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/56
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.
摘要翻译： 本发明涉及用于分析或加工肝素样品的方法和产品。 在一个实施方案中，所述方法包括使样品与肝素酶I，肝素酶II和肝素酶III接触，使用分离方法确定样品中的特征成分的量，并且基于对样品的量 样本中的签名组件到肝素的参考数据库。
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公开(公告)号：US07399604B2
公开(公告)日：2008-07-15
申请号：US11183323
申请日：2005-07-15
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/56
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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9.发明申请公开(公告)号：US20070161073A1
公开(公告)日：2007-07-12
申请号：US11606623
申请日：2006-11-30
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： C12Q1/34
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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公开(公告)号：US20130017565A1
公开(公告)日：2013-01-17
申请号：US13465639
申请日：2012-05-07
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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