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公开(公告)号：US08420067B2
公开(公告)日：2013-04-16
申请号：US12377253
申请日：2007-08-10
申请人： Guy Yeoman Krippner , Charlotte Claire Williams , Brian Devlin Kelly , Scott Andrew Henderson , Zemin Wu , Pasquale Razzino
发明人： Guy Yeoman Krippner , Charlotte Claire Williams , Brian Devlin Kelly , Scott Andrew Henderson , Zemin Wu , Pasquale Razzino
IPC分类号： A61K38/00 , A61K31/74 , A61K31/785
CPC分类号： C08G69/10 , A61K38/00 , A61K47/6885 , C07K5/06026 , C07K14/001 , C08G69/48 , C08G83/003
摘要： The present invention relates generally to branched macromolecules bearing functional moieties. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties. The invention further relates to the use of such macromolecules, particularly in therapeutic applications, and compositions comprising them.
摘要翻译： 本发明一般涉及带有官能部分的支链大分子。 特别地，本发明涉及衍生自具有多个功能部分的赖氨酸或赖氨酸类似物的树枝状大分子。 本发明还涉及这种大分子的用途，特别是在治疗应用中的用途，以及包含它们的组合物。
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公开(公告)号：USD1048445S1
公开(公告)日：2024-10-22
申请号：US29944201
申请日：2024-05-27
申请人： Zemin Wu
设计人： Zemin Wu
摘要： FIG. 1 is a first perspective view of a neck massager showing my new design;
FIG. 2 is a second perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a back view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.
The broken lines shown in the drawings depict portions of the neck massager that form no part of the claimed design.-
公开(公告)号：US20100292148A1
公开(公告)日：2010-11-18
申请号：US12377253
申请日：2007-08-10
申请人： Guy Yeoman Krippner , Charlotte Claire Williams , Brian Devlin Kelly , Scott Andrew Henderson , Zemin Wu , Pasquale Razzino
发明人： Guy Yeoman Krippner , Charlotte Claire Williams , Brian Devlin Kelly , Scott Andrew Henderson , Zemin Wu , Pasquale Razzino
IPC分类号： A61K38/34 , C07K14/47 , A61K38/17 , A61P35/00 , A61P23/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P11/08 , A61P11/10 , A61P37/06 , A61P19/02 , A61P25/08 , A61P7/10 , A61P37/04 , A61P19/10 , C07K14/765 , A61K38/38 , C07K14/685 , A61K38/10 , C07K7/08 , C07D475/08 , A61K38/05 , C07K5/11 , A61K38/07
CPC分类号： C08G69/10 , A61K38/00 , A61K47/6885 , C07K5/06026 , C07K14/001 , C08G69/48 , C08G83/003
摘要： The present invention relates generally to branched macromolecules bearing functional moieties. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties. The invention further relates to the use of such macromolecules, particularly in therapeutic applications, and compositions comprising them.
摘要翻译： 本发明一般涉及带有官能部分的支链大分子。 特别地，本发明涉及衍生自具有多个功能部分的赖氨酸或赖氨酸类似物的树枝状大分子。 本发明还涉及这种大分子的用途，特别是在治疗应用中的用途，以及包含它们的组合物。
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公开(公告)号：USD1044012S1
公开(公告)日：2024-09-24
申请号：US29881216
申请日：2022-12-29
申请人： Zemin Wu
设计人： Zemin Wu
摘要： FIG. 1 is a first perspective view of a beauty instrument showing my new design;
FIG. 2 is a second perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a back view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.
The broken lines shown in the drawings depict portions of the beauty instrument that form no part of the claimed design.-
公开(公告)号：US20100278750A1
公开(公告)日：2010-11-04
申请号：US12377252
申请日：2007-08-10
CPC分类号： C08G83/003 , A61K47/641 , A61K47/6849 , A61K47/6885 , A61K49/124 , A61K49/16 , C08G69/10 , C08G73/028 , C08L77/04
摘要： The present invention relates generally to branched macromolecules and their use as imaging or contrast agents. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties and their application to imaging techniques in which a disease state may be imaged with a targeted contrast agent.
摘要翻译： 本发明一般涉及支化大分子及其作为成像或造影剂的用途。 特别地，本发明涉及衍生自赖氨酸或赖氨酸类似物的树枝状大分子，其具有多个功能部分，并且其应用于可以用靶向造影剂成像疾病状态的成像技术。
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公开(公告)号：US20090324535A1
公开(公告)日：2009-12-31
申请号：US12161688
申请日：2006-05-15
申请人： Benjamin James Boyd , Lisa Michelle Kaminskas , Christopher John Hamilton Porter , Peter Karellas , Guy Yeoman Krippner , Pasquale Razzino , Brian Devlin Kelly , Zemin Wu , Sue Pallich
发明人： Benjamin James Boyd , Lisa Michelle Kaminskas , Christopher John Hamilton Porter , Peter Karellas , Guy Yeoman Krippner , Pasquale Razzino , Brian Devlin Kelly , Zemin Wu , Sue Pallich
IPC分类号： A61K47/48 , C08F283/06 , A61K38/10 , A61K38/16
CPC分类号： C08G65/33396 , A61K31/74 , A61K31/785 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/645 , C08G69/10 , C08G83/003
摘要： The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.
摘要翻译： 本发明涉及具有受控终端基团化学计量的大分子，所述高分子包括表面层，至少一个地下层和至少两个末端基团，所述末端基团包括：第一末端基团，其为药物活性剂的残基，衍生物 或其前体; 和选择用于改变药物活性剂和/或大分子的药代动力学的第二末端基团，其中末端基团化学计量指的是末端基团的数量和类型。
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公开(公告)号：US09127130B2
公开(公告)日：2015-09-08
申请号：US12377252
申请日：2007-08-10
IPC分类号： A61K9/14 , C08G83/00 , A61K47/48 , A61K49/12 , A61K49/16 , C08G69/10 , C08G73/02 , C08L77/04
CPC分类号： C08G83/003 , A61K47/641 , A61K47/6849 , A61K47/6885 , A61K49/124 , A61K49/16 , C08G69/10 , C08G73/028 , C08L77/04
摘要： The present invention relates generally to branched macromolecules and their use as imaging or contrast agents. In particular, the invention relates to dendrimers, derived from lysine or lysine analogs, bearing a plurality of functional moieties and their application to imaging techniques in which a disease state may be imaged with a targeted contrast agent.
摘要翻译： 本发明一般涉及支化大分子及其作为成像或造影剂的用途。 特别地，本发明涉及衍生自赖氨酸或赖氨酸类似物的树枝状大分子，其具有多个功能部分，并且其应用于可以用靶向造影剂成像疾病状态的成像技术。
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公开(公告)号：US08337823B2
公开(公告)日：2012-12-25
申请号：US12161688
申请日：2006-05-15
申请人： Benjamin James Boyd , Lisa Michelle Kaminskas , Christopher John Hamilton Porter , Peter Karellas , Guy Yeoman Krippner , Brian Devlin Kelly , Zemin Wu , Pasquale Razzino , Sue Pallich
发明人： Benjamin James Boyd , Lisa Michelle Kaminskas , Christopher John Hamilton Porter , Peter Karellas , Guy Yeoman Krippner , Brian Devlin Kelly , Zemin Wu , Pasquale Razzino , Sue Pallich
CPC分类号： C08G65/33396 , A61K31/74 , A61K31/785 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/645 , C08G69/10 , C08G83/003
摘要： The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.
摘要翻译： 本发明涉及具有受控终端基团化学计量的大分子，所述高分子包括表面层，至少一个地下层和至少两个末端基团，所述末端基团包括：第一末端基团，其为药物活性剂的残基，衍生物 或其前体; 和选择用于修饰药物活性剂和/或大分子的药代动力学的第二末端基团，其中末端基团化学计量指的是末端基团的数量和类型。
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