公开(公告)号：US20190023681A1

公开(公告)日：2019-01-24

申请号：US16070658

申请日：2016-01-18

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

发明人： Mingxing Yin ,  Dongdong Wu ,  Weijiang Wen

IPC分类号： C07D315/00

CPC分类号： C07D315/00 ,  C07H1/00 ,  C07H1/06 ,  C07H17/00

摘要： A method and an intermediate for preparing a tulathromycin. The method includes the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.

公开(公告)号：US10414746B2

公开(公告)日：2019-09-17

申请号：US16070658

申请日：2016-01-18

申请人： Zhejiang Hisun Pharmaceutical Co., Ltd.

发明人： Mingxing Yin ,  Dongdong Wu ,  Weijiang Wen

IPC分类号： C07D315/00 ,  C07H1/00 ,  C07H17/00 ,  C07H17/08

摘要： A method and an intermediate for preparing a tulathromycin. The method includes the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.