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公开(公告)号：US20190023681A1
公开(公告)日：2019-01-24
申请号：US16070658
申请日：2016-01-18
发明人： Mingxing Yin , Dongdong Wu , Weijiang Wen
IPC分类号： C07D315/00
CPC分类号： C07D315/00 , C07H1/00 , C07H1/06 , C07H17/00
摘要： A method and an intermediate for preparing a tulathromycin. The method includes the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.
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公开(公告)号：US10414746B2
公开(公告)日：2019-09-17
申请号：US16070658
申请日：2016-01-18
发明人： Mingxing Yin , Dongdong Wu , Weijiang Wen
IPC分类号： C07D315/00 , C07H1/00 , C07H17/00 , C07H17/08
摘要： A method and an intermediate for preparing a tulathromycin. The method includes the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.
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公开(公告)号：US10053483B2
公开(公告)日：2018-08-21
申请号：US14389802
申请日：2013-04-02
发明人： Mingxing Yin , Jianchao Wu , Jian Chai
摘要： Provided in the present invention are novel key intermediates of selamectin and the preparation method thereof. Also provided is a new synthesis process, using doramectin as a starting material, and obtaining selamectin via hydrogenation, oxidation, oximation and desugaring. The new process of the present invention has few steps, and is simple to operate, high in yield, low in cost and causes little pollution, and is more suitable for large scale industrial production.
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公开(公告)号：US20150329581A1
公开(公告)日：2015-11-19
申请号：US14389802
申请日：2013-04-02
发明人： Mingxing Yin , Jianchao Wu , Jian Chai
IPC分类号： C07H17/08
摘要： Provided in the present invention are novel key intermediates of selamectin and the preparation method thereof. Also provided is a new synthesis process, using doramectin as a starting material, and obtaining selamectin via hydrogenation, oxidation, oximation and desugaring. The new process of the present invention has few steps, and is simple to operate, high in yield, low in cost and causes little pollution, and is more suitable for large scale industrial production.
摘要翻译： 本发明提供了新颖的新颖的关键中间体及其制备方法。 还提供了使用多拉菌素作为起始原料的新的合成方法，并通过氢化，氧化，肟化和脱除得到塞来林凝胶。 本发明的新工艺步骤很少，操作简单，产量高，成本低，污染少，更适合大规模工业化生产。
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