公开(公告)号：US11774344B2

公开(公告)日：2023-10-03

申请号：US17553841

申请日：2021-12-17

Applicant: ZHEJIANG LAB ,  ZHEJIANG UNIVERSITY

Inventor： Cuihong Li ,  Yuanyuan Ma ,  Zhaoxiong He ,  Shaochong Zhu ,  Zhiming Chen ,  Huizhu Hu

IPC: G01N15/14

CPC classification number: G01N15/1434 ,  G01N2015/1438 ,  G01N2015/1493

Abstract: The present application discloses a nanoparticle recognition device and method based on detection of scattered light with electric dipole rotation. According to the scattering model of nanoparticles, the in situ detection of particle morphology in an optical trap is realized by the methods of particle suspension control and scattered light detection and separation. Specifically, two linearly polarized laser beams are used, wherein the first laser beam suspends nanoparticles and rotates nanoparticles by adjusting the polarization direction; the polarization direction of the second linearly polarized light is unchanged, and scattered light in a specific dipole direction is excited; the change of the polarizability of the nanoparticles is deduced by monitoring the change of the light intensity of the scattered light excited by the second laser beam at the fixed position, so that particle morphology recognition is realized.

公开(公告)号：US11255767B2

公开(公告)日：2022-02-22

申请号：US17372419

申请日：2021-07-10

Applicant: Zhejiang Lab ,  Zhejiang University

Inventor： Zhenhai Fu ,  Cheng Liu ,  Zhiming Chen ,  Xingfan Chen ,  Nan Li ,  Huizhu Hu

IPC: G01N15/02 ,  G01N15/06 ,  G03H1/00

Abstract: A method and a device for measuring light field distribution are provided; including steps of utilizing the optical trap to stably levitating particles, moving the optical trap to bring the particles close to the light field to be measured, and utilizing the photodetector to collect the scattered light signals of the particles at different positions in the three-dimensional space of the light field to be measured, and calculating the light field distribution of the light field to be measured according to the scattered light intensity which is proportional to the light intensity at that position. The device for measuring the optical field distribution includes a laser, an optical trapping path, particles, a photodetector, a control system and an upper computer; the laser emits a laser, passes through the optical trapping path, and emits highly focused captured light B to form an V optical trap to capture particles.

公开(公告)号：US12131835B2

公开(公告)日：2024-10-29

申请号：US17695865

申请日：2022-03-16

Applicant: ZHEJIANG LAB ,  ZHEJIANG UNIVERSITY

Inventor： Cuihong Li ,  Zhiming Chen ,  Yuanyuan Ma ,  Xiaowen Gao ,  Zhenhai Fu ,  Huizhu Hu

IPC: G21K1/00 ,  G02B5/30 ,  G02B27/28

CPC classification number: G21K1/006 ,  G02B5/3083 ,  G02B27/286

Abstract: Disclosed is a multi-dimensional optical tweezers calibration device based on electric field quantity calibration and a method thereof. The polarization-dependent characteristics of a tightly focused optical trap are utilized to realize triaxial electric field force calibration of particles through a one-dimensional electric field quantity calibration device. The method of the present application enables a particle electric field force calibration system to be compatible with particle delivery and particle detection systems; the device is simplified and calibration complexity is reduced.

公开(公告)号：US20210333190A1

公开(公告)日：2021-10-28

申请号：US17372419

申请日：2021-07-10

Applicant: Zhejiang Lab ,  Zhejiang University

Inventor： Zhenhai Fu ,  Cheng Liu ,  Zhiming Chen ,  Xingfan Chen ,  Nan Li ,  Huizhu Hu

IPC: G01N15/02 ,  G01N15/06

Abstract: A method and a device for measuring light field distribution are provided; including steps of utilizing the optical trap to stably levitating particles, moving the optical trap to bring the particles close to the light field to be measured, and utilizing the photodetector to collect the scattered light signals of the particles at different positions in the three-dimensional space of the light field to be measured, and calculating the light field distribution of the light field to be measured according to the scattered light intensity which is proportional to the light intensity at that position. The device for measuring the optical field distribution includes a laser, an optical trapping path, particles, a photodetector, a control system and an upper computer; the laser emits a laser, passes through the optical trapping path, and emits highly focused captured light B to form an V optical trap to capture particles.

公开(公告)号：US12189110B2

公开(公告)日：2025-01-07

申请号：US17691125

申请日：2022-03-10

Applicant: ZHEJIANG LAB ,  ZHEJIANG UNIVERSITY

Inventor： Cuihong Li ,  Zhenhai Fu ,  Jing Jiang ,  Zhiming Chen ,  Yuanyuan Ma ,  Huizhu Hu

IPC: G02B21/32 ,  G21K1/00 ,  G01N15/00

Abstract: Disclosed is an optical trap calibration apparatus and method based on variation of electric field by optical imaging of a nanoparticle. By means of a direct optical imaging method, a linear nanoparticle equilibrium position displacement under the action of a constant electric field is measured to realize calibration, thereby avoiding the introduction of error signals, and improving the reliability of differential calibration. The specific calibration method and apparatus of the present invention are not only suitable for calibration of electric field quantity, but also suitable for the calibration of other magnetic forces and the like. By means of the accurate calibration of mechanical quantity in the present invention, the development and application of the vacuum optical trap sensing technology can be promoted.

公开(公告)号：US11680961B2

公开(公告)日：2023-06-20

申请号：US17888940

申请日：2022-08-16

Applicant: Zhejiang Lab ,  Zhejiang University

Inventor： Yuanyuan Ma ,  Cuihong Li ,  Zhiming Chen ,  Yingying Wang ,  Xunmin Zhu ,  Huizhu Hu

IPC: G01P15/09 ,  G21K1/00 ,  G01P15/093

CPC classification number: G01P15/093 ,  G21K1/006

Abstract: A probe-based bidirectional electrophoretic force optical trap loading method includes steps of (1) detaching target particles from an upper electrode plate and capturing the target particles by a micro-scale probe based on a bidirectional electrophoretic force; (2) moving the probe with the target particles over an optical trap, applying a reverse electric field between the probe and the upper substrate electrode plate which is applied during a polar relaxation time of the target particles, and desorbing the target particles from the probe; and (3) turning on the optical trap, applying an electric field between the lower electrode plate and the upper electrode plate, adjusting the speed of the desorbed target particles through the electric field at which the optical trap is able to capture the desorbed target particles and the desorbed target particles moving to the effective capture range of the optical trap.

公开(公告)号：US20220390482A1

公开(公告)日：2022-12-08

申请号：US17888940

申请日：2022-08-16

Applicant: Zhejiang Lab ,  Zhejiang University

Inventor： Yuanyuan Ma ,  Cuihong Li ,  Zhiming Chen ,  Yingying Wang ,  Xunmin Zhu ,  Huizhu Hu

IPC: G01P15/093 ,  G21K1/00

Abstract: A probe-based bidirectional electrophoretic force optical trap loading method includes steps of (1) detaching target particles from an upper electrode plate and capturing the target particles by a micro-scale probe based on a bidirectional electrophoretic force; (2) moving the probe with the target particles over an optical trap, applying a reverse electric field between the probe and the upper substrate electrode plate which is applied during a polar relaxation time of the target particles, and desorbing the target particles from the probe; and (3) turning on the optical trap, applying an electric field between the lower electrode plate and the upper electrode plate, adjusting the speed of the desorbed target particles through the electric field at which the optical trap is able to capture the desorbed target particles and the desorbed target particles moving to the effective capture range of the optical trap.